Search Results - "proteins"

Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Protein phosphorylation and the control of protein synthesis

Table of Contents: “…Contents: Protein synthesis -- Key step in gene expression that must be tightly controlled -- Signaling pathways regulate phosphorylation and activity of translation factor proteins -- Important in regulation of cell growth and division -- Defective control linked to human diseases such as cancer and cardiac hypertrophy.…”
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Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
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Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
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Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Elongation of protein synthesis structural basis of the process of decoding /

Table of Contents: “…Contents: Fidelity in biological processes -- Elongation step of protein synthesis -- Ribosome structures -- Ribosomes from different organisms -- Errors in protein synthesis -- The decoding problem -- Kinetic proof-reading -- Kinetic model of tRNA selection -- Role of induced fit in tRNA selection -- Recognition of codon-anticodon complexes by the 30S ribosomal subunit -- Local and global conformational changes of the 30S subunit -- Interactions of tRNA during decoding -- Active role of tRNA -- SelB and delivery of Sec-tRNA to the ribosome -- Accommodation of tRNA in the A site.…”
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Series (From DNA to proteins)
Series (Mechanisms of ribosome function)

Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Quality control of proteins mislocalized to the cytosol

Table of Contents: “…Contents: Protein maturation is monitored for failures -- Failures of protein localization in vitro and in vivo -- Mislocalized proteins are selectively recognized -- Relationship between protein maturation & quality control -- Mitochondrial proteins are also prone to mislocalization -- Recognition of mislocalized mitochondrial proteins -- Protein aggregates can disrupt protein quality control -- Key concepts and the future of protein quality control.…”
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Introduction to the ribosome overview of protein synthesis on the ribosome /

Table of Contents: “…Contents: The understanding of heredity and translation of proteins based on the genetic information -- Intensive structural studies of ribosomes, tRNAs and translation factors -- A historical overview -- Main components of translation.…”
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Antibiotic inhibition of ribosome function

Subjects: “…Protein Biosynthesis.…”
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The structural basis for how the large ribosomal subunit catalyses peptide bond formation

Table of Contents: “…Contents: Overview of protein synthesis by the ribosome -- Nature of the polypeptide exit tunnel in the large subunit -- The ribosome is a ribozyme -- Substrate induced fit at the peptidyl transferase center -- Proton shuttle mechanism and transition state stabilization -- Substrate interactions at the large subunit E-site -- Movie of the peptidyl transferase reaction.…”
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Antibiotics that target the 50S ribosomal subunit resistance and other considerations /

Table of Contents: “…-- Analysis of antibacterial market -- Mechanisms of drug resistance -- Sequestration -- How do antibiotics gain entry into cells -- Porins -- Lack of uptake -- Self-promoted uptake drug modification -- Target modifications -- Drug efflux -- Major superfamilies of transport proteins.…”
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High resolution structure of ribosomal subunits RNA/RNA and protein/RNA interactions /

Table of Contents: “…Contents: X-ray crystallography -- Protein synthesis -- High resolution structure of ribosomal subunits -- RNA motifs and interactions -- RNA protein interactions -- Metal ions stabilizing RNA structure -- Functional implications of RNA/RNA and RNA/protein interactions during protein synthesis.…”
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Assembly of the 30S ribosomal subunit in vitro and in cells

Table of Contents: “…Contents: Bacterial ribosome biogenesis -- The Nomura assembly map -- RNA folding and protein binding -- Single molecule fluorescence -- The basis for cooperative assembly -- Isotope pulse chase experiments -- Protein binding kinetics -- The assembly landscape.…”
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Translocation movement of tRNA and mRNA through the ribosome /

Subjects: “…Protein Biosynthesis.…”
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Chemistry of peptide bond formation

Table of Contents: “…Contents: Fundamental processes during protein synthesis -- Peptidyl transfer catalysis by RNA-rich active site -- Ribosome structure solution provided new insights -- Peptide bond formation and peptide release -- Active site of the ribosome -- Universally conserved nucleotides of the active site -- Affinity tag purification of mutant ribosomes -- Active site mutations and rates of peptidyl transfer -- A-site substrates: tRNA vs. puromycin -- "Uninduced" state of ribosome and P-site substrate -- A-site substrates-induced conformational changes -- Peptide release activity of variant ribosomes -- RF catalysis in the large subunit -- RF conserved amino acids in bacteria -- Consequences of RF1 site-directed mutations -- Nucleophile partitioning -- Mutants that lost water specificity -- RF components functioning in activating hydrolysis -- Regulation of translation post-initiation.…”
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Factor independent initiation of protein synthesis by IRES RNAs

Subjects: “…Protein Biosynthesis.…”
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The structure of the intact ribosome and ribosomal subunit interactions

Subjects: “…Protein Biosynthesis.…”
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Structural insights into aminoacyl-tRNA delivery by EF-Tu and translocation by EF-G

Subjects: “…Protein Biosynthesis.…”
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