Search Results - "amyloid"

Prions and amyloids introduction /

Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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Prions and amyloids introduction /

Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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Prions and amyloids introduction /

Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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The dark side of amyloid Pmel17, a natural amyloid in melanosome biogenesis /

Table of Contents: “…Contents: Functional amyloid -- Amyloid fibrils in melanosome ultrastructure and formation -- Pmel17 processing to a fibrillar form -- Evidence that Pmel17 fibrils are amyloid -- Role of multivesicular bodies in Pmel17 amyloid formation -- Multivesicular bodies in amyloid formation by other substrates.…”
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Mechanism of prion generation in vitro

Subjects: “…Amyloid.…”
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The genetics and biology of the [Het-s] prion of Podospora

Subjects: “…Amyloid.…”
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Mechanisms of yeast prion propagation

Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Yeast and fungal prions a help or a hindrance? /

Subjects: “…Amyloid.…”
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Yeast prions and protein chaperones a help or a hindrance? /

Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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Molecular structure of amyloid and prion fibrils insights from solid state NMR /

Table of Contents: “…Contents: Overview of solid state NMR methodology -- Structural model for Alzheimer's beta-amyloid fibrils -- Self-propagating polymorphism in amyloid fibrils -- Molecular basis of beta-amyloid polymorphism -- Extension of solid state NMR methods to amylin fibrils and yeast prion fibrils -- Structural basis of the generic nature of amyloid formation.…”
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[PIN+] prions beget prions /

Subjects: “…Amyloid.…”
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Propagation and variability of the yeast [PSI+] prion

Table of Contents: “…Contents: Prion -- Yeast prions as non-chromosomal genetic determinants -- Modular structure of the Sup35 protein responsible for the yeast [PSI+] prion -- Role of the Hsp104 chaperone in [PSI+] prion propagation -- Two-level structure of the [PSI+] prion aggregates and methods for studying the size of prion polymers -- Non-prion amyloids in yeast -- Variability of the yeast [PSI+] prion.…”
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Similarities between prion diseases and other neurodegenerative diseases

Subjects: “…Amyloid.…”
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Predicting TSE transmission

Subjects: “…Amyloid.…”
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Generation and propagation of infectious prions by cyclic amplification of protein misfolding

Subjects: “…Amyloid.…”
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The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

Table of Contents: “…Contents: 3D structure is important -- Prion hypothesis -- Prions can form amyloids -- Amyloids -- Cross-beta arrangements give characteristic fiber diffraction patterns -- Solid-state NMR can characterize amyloid fibrils -- Atomic-resolution structure determination by NMR and x-ray -- Distance information in NMR correlation spectra -- The methodology to obtain 3D structures from solid (microcrystalline) samples has recently been developed -- Structure determination is possible -- Nevertheless, amyloids are different -- Isotopic labeling allows to disentangle the intra/inter problem -- HET-s: a functional prion -- Structural information about HET-s (218-289) from earlier measurements -- Chemical shift assignment -- To go further we need distance restraints -- Distance restraints for protein fibrils -- Intramolecular restraints -- Structure calculation -- Structural features of the fibrils -- Comparison with globular proteins.…”
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Transgenic mouse models of prion diseases

Subjects: “…Amyloid.…”
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The genetics and biology of the [Het-s] prion of Podospora

Subjects: “…Amyloid. 112825…”
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Mechanisms of yeast prion propagation

Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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