Search Results - "prion"

Prion diseases

Table of Contents: “…Contents: Normal function of prion protein -- Prion diseases -- Mechanism of propagation of PrP -- Propagation in acquired and familial forms -- Pathogenic hypothesis -- Human pathogenic mutation and polymorphisms -- Laboratory methods -- Epidemiology -- Sporadic prion diseases -- New variant CJD -- Treatment of prion disease.…”
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Prion diseases

Table of Contents: “…Contents: Understanding the biophysical aspects of a disease of protein misfolding -- Structural studies of PrPc and PrPsc -- The development of synthetic mammalian prions and the proof of their infectivity and serial transmissibility -- Heterocyclic pharmacotherapies for prion disease -- Pyridinyl based therapies and structure based design -- Serendipitous discovery of acridines as anti-prion agents -- Bisacridines as potent inhibitors of prion replication in cell culture -- The relationship between the prion diseases and other diseases of protein misfolding.…”
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Chaperones and prions

Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Prion-like propagation of Parkinson's disease

Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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Endoplasmic reticulum stress in neurodegenerative diseases

Table of Contents: “…Contents: Neurodegenerative disease -- Misfolded aggregates deposited in the brain -- Research strategy -- Prion diseases -- Two conformations of the prion protein -- Experimental scrapie model in mice -- Upregulation of ER chaperones -- ER-stress and UPR in human CJD -- PrP interaction with ER chaperones in brain -- PrPSc induction of ER-stress and neuronal death -- Calcineurin properties -- A novel treatment for prion diseases.…”
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Novel approaches to treating symptoms and slowing the progress of neurodegenerative diseases

Table of Contents: “…Contents: Brief overview of dementia -- Current treatments for Alzheimer's disease -- Role of muscarinic receptors in learning and memory -- Using prion disease as a model -- Effects of muscarinic receptor drugs on learning and memory deficits in prion disease -- Types of drugs for different stages of Alzheimer's disease.…”
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