Search Results - "proteins"
Suggested Topics within your search.
Suggested Topics within your search.
- Neurodegenerative Diseases
- Degeneration 64
- Nervous system 64
- genetics 34
- pathology 34
- Diseases 30
- Alzheimer Disease 26
- metabolism 23
- Genetic aspects 21
- Proteins 21
- Alzheimer's disease 19
- Protein Folding 18
- Protein folding 15
- Frontotemporal Dementia 13
- Prion Diseases 12
- therapy 12
- Brain 11
- Frontotemporal dementia 9
- Metabolism 9
- Prion diseases 9
- Protein Conformation 9
- Ubiquitin 9
- drug therapy 9
- tau Proteins 9
- Huntington Disease 8
- Molecular aspects 8
- Pathology 8
- Stress, Physiological 8
- Amyloid 7
- Amyotrophic Lateral Sclerosis 7
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1
Protein aggregation, metals and oxidative stress in neurodegenerative diseases
Published 2007Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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2
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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3
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Electronic Video -
4
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Electronic Video -
5
Protein aggregation, metals and oxidative stress in neurodegenerative diseases
Published 2007Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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Series
Electronic Video -
6
Protein aggregation, metals and oxidative stress in neurodegenerative diseases
Published 2007Table of Contents: “…Contents: Introduction to protein conformational brain diseases -- Alzheimer's disease, A-beta and tau -- A-beta oligomers and toxicity -- A-beta generates hydrogen peroxide -- Results from experiments using electron spin resonance spectroscopy -- Parkinson's disease -- Generation of hydrogen peroxide from alpha synuclein, toxic fragments of the prion protein and the familial British dementia peptide -- Early oligomers appear to generate hydrogen peroxide -- Huntington's disease -- Protein aggregates could be protective -- Potential common toxic pathway for these brain diseases.…”
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Series
Electronic Video -
7
The role of MAPT (Tau) in neurodegenerative disease one bullet with many triggers /
Published 2007Table of Contents: “…Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications.…”
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8
Protein degradation and defense against neurodegenerative disease part 1 of 2 /
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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9
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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10
Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /
Published 2007Table of Contents: “…Contents: Protein pathology of disease -- Loci underlying autosomal dominant neurodegenerative disease -- Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease -- Tau mutations cause autosomal dominant frontal temporal dementia -- Alpha-synuclein mutations cause autosomal dominant Parkinson's disease -- How genetic variability of these genes contributes to the risk of sporadic disease.…”
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11
Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /
Published 2021Table of Contents: “…Contents: Protein pathology of disease -- Loci underlying autosomal dominant neurodegenerative disease -- Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease -- Tau mutations cause autosomal dominant frontal temporal dementia -- Alpha-synuclein mutations cause autosomal dominant Parkinson's disease -- How genetic variability of these genes contributes to the risk of sporadic disease.…”
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Electronic Video -
12
Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /
Published 2021Table of Contents: “…Contents: Protein pathology of disease -- Loci underlying autosomal dominant neurodegenerative disease -- Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease -- Tau mutations cause autosomal dominant frontal temporal dementia -- Alpha-synuclein mutations cause autosomal dominant Parkinson's disease -- How genetic variability of these genes contributes to the risk of sporadic disease.…”
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13
Protein degradation and defense against neurodegenerative disease part 2 of 2 /
Published 2014Subjects: Get full text
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14
Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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15
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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Series
Electronic Video -
16
Roles for Hsp40 molecular chaperones in protein misfolding disease
Published 2012Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
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Series
Electronic Video -
17
Protein degradation and defense against neurodegenerative disease part 1 of 2 /
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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Series
Electronic Video -
18
Protein degradation and defense against neurodegenerative disease part 2 of 2 /
Published 2014Subjects: Get full text
Series
Electronic Video -
19
Protein degradation and defense against neurodegenerative disease part 1 of 2 /
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases with inclusion bodies associated with ubiquitin and proteasomes -- Abnormal proteins rapidly degraded in cells -- The ubiquitin-proteasome pathway -- Ubiquitin ligases important in neurological disease -- CHIP, Hsp70 and Hsp90 -- Conditions that induce muscle wasting -- Ubiquitin ligases in muscles atrophy -- P97/VCP -- Autophagy -- The Nedd4 ubiquitin-ligase and α-Synuclein -- The ESCRT pathway -- Proteasomal VS. lysosomal degradation (K48 and K63-linked chains) -- Expression of Nedd4 in Lewy bodies.…”
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Electronic Video -
20
Protein degradation and defense against neurodegenerative disease part 2 of 2 /
Published 2014Subjects: Get full text
Series
Electronic Video