Search Results - "amyloid"

A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
Get full text
Series

Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
Get full text
Series

Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
Get full text
Series

Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /

Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
Get full text
Series

Update on fluid biomarkers for neurodegenerative diseases

Table of Contents: “…Contents: Fluid biomarker candidates for neurodegenerative disease -- Amyloid pathology -- CSF and plasma/serum NfL -- CSF Aβ42 in Alzheimer's disease and neuroinflammatory diseases -- Tau pathology in Alzheimer's disease -- Neurodegeneration -- CSF and plasma NfL as biomarkers for disease progression -- Drug treatment and NfL levels.…”
Get full text
Series (Biomarkers)
Series (Drug discovery and development in the neurosciences)
Series (Genetic basis of neurological disorders)

Update on fluid biomarkers for neurodegenerative diseases

Table of Contents: “…Contents: Fluid biomarker candidates for neurodegenerative disease -- Amyloid pathology -- CSF and plasma/serum NfL -- CSF Aβ42 in Alzheimer's disease and neuroinflammatory diseases -- Tau pathology in Alzheimer's disease -- Neurodegeneration -- CSF and plasma NfL as biomarkers for disease progression -- Drug treatment and NfL levels.…”
Get full text
Series (Biomarkers)
Series (Drug discovery and development in the neurosciences)
Series (Genetic basis of neurological disorders)

Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
Get full text
Series

Frontotemporal dementia

Table of Contents: “…Contents: Prevalence and nomenclature of FTD -- The pathology of FTD (tau, TDP-43) -- The genetics of FTD (tau, progranulin) -- Patterns of atrophy and neuroanatomical correlates of behavior and cognition -- von Economo neurons -- Neuroimaging (amyloid imaging) -- Treatment.…”
Get full text
Series

A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
Get full text
Series

A molecular understanding of Alzheimer's disease

Table of Contents: “…Contents: Usefulness of genetics in understanding AD -- Pathology of diseases -- Amyloid protein -- Genetic maps -- Mechanism of late onset Alzheimer's -- Role of presenilin in amyloid pathology -- Tau and frontotemporal dementia -- Tau splice site mutations -- Pathways to neurodegeneration.…”
Get full text
Series

Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

Subjects: Get full text
Series

Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /

Subjects: Get full text
Series

Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
Get full text
Series

Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
Get full text
Series

Experimental therapies in Alzheimer's disease the development and use of mouse models /

Table of Contents: “…Contents: Animal models and AD research -- Role in identifying pathological pathways, biomarkers and candidate therapies -- Design of models and associated technical parameters -- Process of transgenesis -- Developing mouse models for beta-amyloid precursor protein mutations -- TgCRND8 mice -- Transgenic approaches for investigating Tau mutations -- Exploring environmental modifiers of beta-amyloid pathobiology -- Candidate chemical risk-factor for sporadic AD -- Potential of ''smart'' beta-amyloid-directed interventions.…”
Get full text
Series

Roles for Hsp40 molecular chaperones in protein misfolding disease

Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series

Roles for Hsp40 molecular chaperones in protein misfolding disease

Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series

Roles for Hsp40 molecular chaperones in protein misfolding disease

Table of Contents: “…Contents: Protein aggregation in conformational disease -- The Hsp40 system -- The Hsp70 system -- Small oligomers, prion, yeast, Huntington's disease and protein triage -- Mechanisms for proteotoxicity -- Mechanisms for amyloid disease.…”
Get full text
Series

Molecular brain imaging (PET) in diseases with dementia

Table of Contents: “…Contents: Brain imaging with positron emission tomography (PET) for dementia diagnosis and research -- Cerebral glucose metabolism in mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia & depression -- Imaging of pathological markers (beta-amyloid and tau) in Alzheimer's disease -- Imaging of neurotransmitters and receptors, in the dopaminergic and cholinergic system -- Multiple systems profiling in dementia, Parkinson's and related motor disorders.…”
Get full text
Series (Periodic reports)
Series (Neurodegenerative diseases)

Molecular brain imaging (PET) in diseases with dementia

Table of Contents: “…Contents: Brain imaging with positron emission tomography (PET) for dementia diagnosis and research -- Cerebral glucose metabolism in mild cognitive impairment, Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia & depression -- Imaging of pathological markers (beta-amyloid and tau) in Alzheimer's disease -- Imaging of neurotransmitters and receptors, in the dopaminergic and cholinergic system -- Multiple systems profiling in dementia, Parkinson's and related motor disorders.…”
Get full text
Series (Periodic reports)
Series (Neurodegenerative diseases)