Search Results - "survivalism"

Protoporphyrin IX (PpIX)-conjugated self-lighting nanoparticles for photodynamic therapy synthesis and characterization /

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EGFR inhibitors in NSCLC and the role of biomarkers for selection of patients

Table of Contents: “…Contents: USAEGFR TKIs in 2nd /3rd line therapy -- Phase II activity of EGFR TKIs in unselected NSCLC -- BR.21 study design and overall survival -- Forest plot of survival by subsets -- Is there a survival advantage for male smokers with squamous-cell carcinoma? …”
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Chromosome translocations and cancer

Table of Contents: “…Contents: Chromosome translocations -- Fusion genes in cancer -- Chromosome aberrations in cancer -- Clinical significance of findings -- Prognostic significance -- Imatinib targeted treatment in CML -- Survival of CML patients -- From discovery to targeted treatment.…”
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Celiac plexus block

Table of Contents: “…Contents: Anatomy -- Demographics of pancreatic cancer pain -- US cancer deaths -- Relative survival -- Pancreatic cancer risk factors -- Pancreatic cancer pain -- Retrocrural anatomy and pancreatic cancer -- Celiac Technique -- Neurolytic celiac plexus block in cancer pain: a meta-analysis -- Block outcome -- Managing risks of technique.…”
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Surrogate endpoints of efficacy

Table of Contents: “…Contents: Improvement in overall survival must be considered the single most important goal of any new antineoplastic strategy -- Also increasingly recognized that in well-defined settings it is reasonable to employ other objectively measurable endpoints of efficacy such as time to symptomatic disease progression -- The rationale for the use of surrogate or alternative endpoints in cancer clinical trials -- Examples of where such endpoints may be appropriately utilized.…”
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Understanding cancer trends

Table of Contents: “…Contents: Current trends in cancer incidence, mortality and relative survival in the US -- Understanding how improvements in prevention, early detection and treatment affect these trends -- How demographic changes affect the number of cancer cases and deaths but not the age-standardized incidence or death rates -- Specific cancer sites for which the incidence and/or death rates are changing -- Role of prevention, early detection, and improvements in treatment in reducing the burden of cancer.…”
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Hope and Suffering Children, Cancer, and the Paradox of Experimental Medicine / by Krueger, Gretchen Marie

Table of Contents: “…: remission, relapse, and child death in the 1960s and 1970s -- "The truly cured child": prolonged survival and the late effects of cancer.…”
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Hope and Suffering : Children, Cancer, and the Paradox of Experimental Medicine / by Krueger, Gretchen Marie

Table of Contents: “…: remission, relapse, and child death in the 1960s and 1970s -- "The truly cured child": prolonged survival and the late effects of cancer.…”
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A Darwinian eye view of cancer

Table of Contents: “…Contents: The prevalence of cancer: man vs. animals -- The proximal causes of cancer: mutations and genotoxic exposures -- Limitations of evolutionary adaptation by natural selection -- Vulnerability to cancer from an evolutionary perspective -- Lack of perfection in evolutionary 'engineering': faults/trade-offs -- Evolutionary adaptation 'has no eyes to the future': mismatches between genetics and lifestyle -- Natural selection will happen: evolution of robust cancer clones -- The only fitness test of 'natural selectability' in evolution is survival and reproductive success: cancer risk escalation in old age.…”
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EGFR targeted therapies in lung cancer

Table of Contents: “…Contents: Lung cancer: facts and figures -- Lung cancer survival -- Lung cancer burden -- EGFR targeted therapeutics -- EGFR mutations -- Why Do EGFR inhibitors work so well in EGFR mutant cancers? …”
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Changing paradigms in anticancer drug development inhibiting angiogenesis in colorectal cancer /

Table of Contents: “…Contents: Targeted therapy for cancer -- Angiogenesis is involved throughout tumour formation, growth and metastasis -- VEGF: molecular characteristics -- VEGF and other signals promote the angiogenic switch in tumours -- Tumour vasculature is abnormal -- VEGF produces immature tortuous vessels dependent on VEGF for survival -- Other features make VEGF an attractive target for anticancer therapy -- RhuMAb VEGF (bevacizumab/Avastin®) -- Significant reduction in microvasculature -- Anti-VEGF antibody improves drug delivery -- Avastin: an anti-VEGF agent for cancer therapy -- Use of Avastin with oxaliplatin-based therapy -- Addition of Avastin to oxaliplatin-based chemotherapy improved best confirmed response -- Study schema and organization.…”
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Germline pharmacogenomics as a tool to individualize therapy in breast cancer

Table of Contents: “…Contents: Major clinical issues in the personalized treatment of breast cancer -- The efficacy barrier: tamoxifen and anastrozole -- Advances in targeting that have improved the treatment of breast cancer -- Tumor-based expression arrays -- Prognostic expression arrays remain valuable beyond tumor grade and stage -- Pharmacogenetic principles -- Principles for valuable predictive biomarkers -- COBRA -- Anti-estrogen therapy for breast cancer -- The ELPH trial -- Aromatase inhibitor side effects in the ELPH trial -- The problem with aromatase inhibitors in Asia -- Breast cancer around the world -- Classic understanding of tamoxifen pharmacology -- Tamoxifen metabolism -- Endoxifen -- Serum concentrations of tamoxifen and metabolites predict efficacy -- CYP2D6 -- Relapse-free survival was worse in poor metabolizers -- Clinical consequences -- Pharmacodynamic pharmacogenomics -- Multiple targets to inhibit angiogenesis -- Bevacizumab in breast cancer.…”
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Bevacizumab the first FDA-approved angiogenesis inhibitor in the treatment of non-small cell lung cancer /

Table of Contents: “…Contents: Lung cancer incidence -- Survival by treatment group -- Selected trials of novel agents + chemotherapy -- Bevacizumab -- Vascular Endothelial Growth Factor (VEGF) -- Principles of angiogenesis -- Bevacizumab in NSCLC: not for everybody -- Randomized phase II trial of Paclitaxel/Carboplatin with/without Bevacizumab in NSCLC -- Hemorrhagic events -- Example of tumor cavitation in lung following treatment with chemotherapy and Bevacizumab -- Patient haracteristics -- Response rates -- Hematologic and non-hematologic toxicity -- Treatment related deaths -- Efficacy by gender and age -- NCCN pactice guidelines in oncology-v.2.2008 -- AVAiL: phase III trial of Bevacizumab + Gemcitabine and Cisplatin in advanced non|squamous cell NSCLC -- Second line therapy for advanced NSCLC: the role of Bevacizumab -- Adjuvant therapy in NSCLC -- Can a broader range of patients be safely treated with Bevacizumab? …”
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Natural killer cells development, diversity and applications to human disease /

Table of Contents: “…-- NK progenitor, NK precursor, mature NK cell -- Only CD34dimCD45RA(+) HPC differentiate into CD56bright NK cells -- NK cells are in human lymph nodes and are CD56bright -- Putative stages of human NK cell differentiation in nodes/tonsils -- How NK cell development fits in human lymphopoiesis -- IL-15 and human NK cell survival -- Adoptive transfer of NK cells into IL-15-deficient mice -- IL-15 transgene -- Lymphoblastic leukemia -- Human NK cell subsets -- Do NK cell subsets have unique immunoregulatory roles? …”
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