Search Results - "stem cell"

Stem cells immortality or healthy old age? /

Table of Contents: “…Contents: What is a stem cell? -- Properties of stem cells -- Adult and embryonic stem cells -- What is immortality? …”
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Cancer stem cells

Table of Contents: “…Contents: Introduction to normal and cancer stem cell (CSCs) -- Leukemia CSCs -- Solid tumor CSCs -- Possible origin of CSCs -- Functional assays for CSCs -- Conversion of non-CSCs to CSCs -- Epithelial-mesenchymal transition (EMT) -- CSC plasticity and heterogeneity -- Signaling and epigenetic regulators of CSCs -- CSC niche -- Role of CSCs in therapeutic resistance -- Strategies for targeting CSCs.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Genetics of tumor metastasis part 2 of 2 /

Table of Contents: “…Contents: Re-examining the stem-cell tumor model -- Interconvertibility between non-stem cells and stem cells -- The key for generating cancer stem cells (CSCs) from non-cancer stem cells -- Filopodium-like structures (FLPs) in metastatic cancer -- Mechanistic link between epithelial/mesenchymal transition (EMT) & the CSC state.…”
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Latest development in therapy-related autophagy research

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Increasing tumor targeting efficacy by nanomedicine

Table of Contents: “…Contents: Rationale: low target efficacy drugs -- Physiochemical properties of nanoparticles -- Mesenchymal stem cell-nanodrug delivery -- Transportation to cancer organelles.…”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Endothelial cell apoptosis

Table of Contents: “…Contents: Endothelial apoptosis -- Role in tumor response to radiation therapy -- Tissue damage results from depletion of stem cells and cells with clonogenic capacity -- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death -- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation -- Sphingomyelin -- Ceramide -- GI tract and bone marrow: very radiation responsive -- Growth patterns of tumors -- The two-target model for single-dose radiotherapy of experimental tumors -- Engaging the vascular component of tumor response to radiation.…”
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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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