Search Results - "metastasis"

Genetics of tumor metastasis part 2 of 2 /

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Genetics of tumor metastasis part 2 of 2 /

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Genetics of tumor metastasis part 2 of 2 /

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How tumor-microenvironment interactions drive or inhibit metastasis

Table of Contents: “…Contents: Tumor Organismal Environment (TOE) and Tumor Microenvironment (TME) -- Principles of intra-TME interactions -- Tumor progression and regression -- Site-specific metastasis -- The pre-metastatic niche -- The metastatic cascade -- Epithelial to Mesenchymal Transition (EMT) -- Targeting tumor-TME interactions -- Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells.…”
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How tumor-microenvironment interactions drive or inhibit metastasis

Table of Contents: “…Contents: Tumor Organismal Environment (TOE) and Tumor Microenvironment (TME) -- Principles of intra-TME interactions -- Tumor progression and regression -- Site-specific metastasis -- The pre-metastatic niche -- The metastatic cascade -- Epithelial to Mesenchymal Transition (EMT) -- Targeting tumor-TME interactions -- Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Solution proposed to a 2000 year old problem in oncology

Table of Contents: “…Contents: Primary cancer surgery -- Systemic inflammation -- Metastatic amplification -- Perioperative inflammation as triggering origin of metastasis development -- Hazards of relapse -- Computer simulations and clinical observations -- The linkage between wounding, immunology, inflammation and oncology -- Ketorolac and the uses of perioperative NSAIDs.…”
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Solution proposed to a 2000 year old problem in oncology

Table of Contents: “…Contents: Primary cancer surgery -- Systemic inflammation -- Metastatic amplification -- Perioperative inflammation as triggering origin of metastasis development -- Hazards of relapse -- Computer simulations and clinical observations -- The linkage between wounding, immunology, inflammation and oncology -- Ketorolac and the uses of perioperative NSAIDs.…”
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Solution proposed to a 2000 year old problem in oncology

Table of Contents: “…Contents: Primary cancer surgery -- Systemic inflammation -- Metastatic amplification -- Perioperative inflammation as triggering origin of metastasis development -- Hazards of relapse -- Computer simulations and clinical observations -- The linkage between wounding, immunology, inflammation and oncology -- Ketorolac and the uses of perioperative NSAIDs.…”
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Clinical applications of molecular imaging imaging to guide cancer therapy /

Table of Contents: “…Contents: Anatomic vs. functional imaging -- Functional imaging modalities -- PET/CT -- Radiotracer imaging -- Existing cancer imaging paradigm -- A new paradigm for cancer imaging -- Imaging and targeted therapy -- Biomarker imaging -- ER expression and breast cancer endocrine therapy -- Hypoxia-specific treatment -- Biologic events in response to successful cancer therapy -- Thymidine incorporation pathways -- Bone metastasis response monitoring -- FDG PET vs. bone scan -- Neo-adjuvant therapy of breast cancer -- Molecular imaging is a tool for measuring in vivo biology -- Changes in breast cancer metabolism and blood flow predict pathologic response -- Clinical trial of novel molecular imaging probes for cancer -- ACRIN experimental imaging sciences committee.…”
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Changing paradigms in anticancer drug development inhibiting angiogenesis in colorectal cancer /

Table of Contents: “…Contents: Targeted therapy for cancer -- Angiogenesis is involved throughout tumour formation, growth and metastasis -- VEGF: molecular characteristics -- VEGF and other signals promote the angiogenic switch in tumours -- Tumour vasculature is abnormal -- VEGF produces immature tortuous vessels dependent on VEGF for survival -- Other features make VEGF an attractive target for anticancer therapy -- RhuMAb VEGF (bevacizumab/Avastin®) -- Significant reduction in microvasculature -- Anti-VEGF antibody improves drug delivery -- Avastin: an anti-VEGF agent for cancer therapy -- Use of Avastin with oxaliplatin-based therapy -- Addition of Avastin to oxaliplatin-based chemotherapy improved best confirmed response -- Study schema and organization.…”
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Clinical applications of molecular imaging imaging to guide cancer therapy /

Table of Contents: “…Contents: Anatomic vs. functional imaging -- Functional imaging modalities -- PET/CT -- Radiotracer imaging -- Existing cancer imaging paradigm -- A new paradigm for cancer imaging -- Imaging and targeted therapy -- Biomarker imaging -- ER expression and breast cancer endocrine therapy -- Hypoxia-specific treatment -- Biologic events in response to successful cancer therapy -- Thymidine incorporation pathways -- Bone metastasis response monitoring -- FDG PET vs. bone scan -- Neo-adjuvant therapy of breast cancer -- Molecular imaging is a tool for measuring in vivo biology -- Changes in breast cancer metabolism and blood flow predict pathologic response -- Clinical trial of novel molecular imaging probes for cancer -- ACRIN experimental imaging sciences committee.…”
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Clinical applications of molecular imaging imaging to guide cancer therapy /

Table of Contents: “…Contents: Anatomic vs. functional imaging -- Functional imaging modalities -- PET/CT -- Radiotracer imaging -- Existing cancer imaging paradigm -- A new paradigm for cancer imaging -- Imaging and targeted therapy -- Biomarker imaging -- ER expression and breast cancer endocrine therapy -- Hypoxia-specific treatment -- Biologic events in response to successful cancer therapy -- Thymidine incorporation pathways -- Bone metastasis response monitoring -- FDG PET vs. bone scan -- Neo-adjuvant therapy of breast cancer -- Molecular imaging is a tool for measuring in vivo biology -- Changes in breast cancer metabolism and blood flow predict pathologic response -- Clinical trial of novel molecular imaging probes for cancer -- ACRIN experimental imaging sciences committee.…”
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Tumor-associated macrophages

Table of Contents: “…Contents: The correlation between Tumor Associated Macrophage (TAM) infiltration and tumor progression in cancer patients -- Evidence for a protumoral function of TAMs in mouse tumor models -- Hallmark features of TAMs enable tumor progression -- Promotion of inflammation -- Chronic inflammatory diseases and cancer risk -- Promotion of matrix remodeling -- Promotion of tumor cell invasion -- Promotion of metastasis -- Promotion of angiogenesis -- TAM heterogeneity in tumors -- Identification and characterization of TAM subsets in mouse tumor models -- TIE2-expressing macrophages and inflammatory TAMs -- Origins of TAM subsets: Distinct hypothesis -- Tumor responses to anticancer therapies: Role of TAMs -- Reprogramming TAMs from a pro- to an anti-tumoral function -- Deciphering TAM heterogeneity in human cancer -- Complexity of leukocyte infiltrates in human cancer.…”
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Changing paradigms in anticancer drug development inhibiting angiogenesis in colorectal cancer /

Table of Contents: “…Contents: Targeted therapy for cancer -- Angiogenesis is involved throughout tumour formation, growth and metastasis -- VEGF: molecular characteristics -- VEGF and other signals promote the angiogenic switch in tumours -- Tumour vasculature is abnormal -- VEGF produces immature tortuous vessels dependent on VEGF for survival -- Other features make VEGF an attractive target for anticancer therapy -- RhuMAb VEGF (bevacizumab/Avastin®) -- Significant reduction in microvasculature -- Anti-VEGF antibody improves drug delivery -- Avastin: an anti-VEGF agent for cancer therapy -- Use of Avastin with oxaliplatin-based therapy -- Addition of Avastin to oxaliplatin-based chemotherapy improved best confirmed response -- Study schema and organization.…”
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Series

Changing paradigms in anticancer drug development inhibiting angiogenesis in colorectal cancer /

Table of Contents: “…Contents: Targeted therapy for cancer -- Angiogenesis is involved throughout tumour formation, growth and metastasis -- VEGF: molecular characteristics -- VEGF and other signals promote the angiogenic switch in tumours -- Tumour vasculature is abnormal -- VEGF produces immature tortuous vessels dependent on VEGF for survival -- Other features make VEGF an attractive target for anticancer therapy -- RhuMAb VEGF (bevacizumab/Avastin®) -- Significant reduction in microvasculature -- Anti-VEGF antibody improves drug delivery -- Avastin: an anti-VEGF agent for cancer therapy -- Use of Avastin with oxaliplatin-based therapy -- Addition of Avastin to oxaliplatin-based chemotherapy improved best confirmed response -- Study schema and organization.…”
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Series

Tumor-associated macrophages

Table of Contents: “…Contents: The correlation between Tumor Associated Macrophage (TAM) infiltration and tumor progression in cancer patients -- Evidence for a protumoral function of TAMs in mouse tumor models -- Hallmark features of TAMs enable tumor progression -- Promotion of inflammation -- Chronic inflammatory diseases and cancer risk -- Promotion of matrix remodeling -- Promotion of tumor cell invasion -- Promotion of metastasis -- Promotion of angiogenesis -- TAM heterogeneity in tumors -- Identification and characterization of TAM subsets in mouse tumor models -- TIE2-expressing macrophages and inflammatory TAMs -- Origins of TAM subsets: Distinct hypothesis -- Tumor responses to anticancer therapies: Role of TAMs -- Reprogramming TAMs from a pro- to an anti-tumoral function -- Deciphering TAM heterogeneity in human cancer -- Complexity of leukocyte infiltrates in human cancer.…”
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Series

Tumor-associated macrophages

Table of Contents: “…Contents: The correlation between Tumor Associated Macrophage (TAM) infiltration and tumor progression in cancer patients -- Evidence for a protumoral function of TAMs in mouse tumor models -- Hallmark features of TAMs enable tumor progression -- Promotion of inflammation -- Chronic inflammatory diseases and cancer risk -- Promotion of matrix remodeling -- Promotion of tumor cell invasion -- Promotion of metastasis -- Promotion of angiogenesis -- TAM heterogeneity in tumors -- Identification and characterization of TAM subsets in mouse tumor models -- TIE2-expressing macrophages and inflammatory TAMs -- Origins of TAM subsets: Distinct hypothesis -- Tumor responses to anticancer therapies: Role of TAMs -- Reprogramming TAMs from a pro- to an anti-tumoral function -- Deciphering TAM heterogeneity in human cancer -- Complexity of leukocyte infiltrates in human cancer.…”
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