Search Results - "epigenetics"

Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Epigenetic pharmaceuticals used in the clinic

Table of Contents: “…Contents: Epigenetic drugs in chemotherapy -- Selecting patients for epigenetic therapy -- Side effects of epigenetic agents -- Unique therapeutic mechanisms of epigenetic treatments -- How is epigenetic therapy applied? …”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Enhancer malfunction in cancer

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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The Myc transcription factor network

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Series (Epigenetics, chromatin, transcription and cancer)

O-GlcNAc, an essential regulator of numerous cellular pathways

Table of Contents: “…Contents: O-GlcNAc -- A Novel Intracellular Glycan -- Biosynthesis of O-GlcNAc -- Mechanisms by which O-GlcNAc regulates proteins -- Cellular pathways and diseases regulated by O-GlcNAc -- Epigenetics and transcription -- Translation -- Cell cycle -- Nutritional sensing -- Neurodegeneration -- Cancer -- The cellular stress response.…”
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Cancer stem cells

Table of Contents: “…Contents: Introduction to normal and cancer stem cell (CSCs) -- Leukemia CSCs -- Solid tumor CSCs -- Possible origin of CSCs -- Functional assays for CSCs -- Conversion of non-CSCs to CSCs -- Epithelial-mesenchymal transition (EMT) -- CSC plasticity and heterogeneity -- Signaling and epigenetic regulators of CSCs -- CSC niche -- Role of CSCs in therapeutic resistance -- Strategies for targeting CSCs.…”
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