Search Results - "DNA"

DNA methylation in cancer

Table of Contents: “…Contents: DNA methylation in cancer -- Overview of DNA methylation in human cells -- Relationshoip of DNA methylation and chromatin structure -- Contribution of hypo/hypermethylation to tumorigenesis -- Mechanisms underlying altered DNA methylation patterns in cancer -- miRNAs as effectors and targets of aberrant DNA methylation in cancer -- Cancer methylation biomarkers -- Reversing DNA methylation in cancer therapy.…”
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DNA methylation, inflammation and cancer

Table of Contents: “…Contents: DNA methylation in cancer in general -- Lung cancer -- Intestinal cancer -- Inflammation -- Method for genome-wide DNA methylation profiling -- Association of the Polycomb complex with DNA methylation in inflammation and cancer.…”
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Single nucleotide polymorphism microarrays in the analysis of cancer

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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Virology and cancer biology part 2, DNA viruses associated with transformation and tumor formation : the discovery of tumor suppressor genes /

Table of Contents: “…Contents: DNA viruses and transformation -- Viral T antigen and cell cycle control -- The linkage between Cell cycle, T antigens, Rb, E2F and p53 -- Transformation as an epiphenomenon of DNA viruses.…”
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O-GlcNAc, an essential regulator of numerous cellular pathways

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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Circulating nucleic acids as biomarkers in cancer patients

Table of Contents: “…Contents: Circulating Nucleic Acids -- Advantages of Serum/Plasma DNA vs. Tumor Tissue DNA -- Circulating DNA in patients with benign disease and malignant tumors -- Circulating microRNAs in cancer patients -- Associations between Circulating Tumor Cells and cell-free tumor DNA in cancer patients.…”
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The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Series (Epigenetics, chromatin, transcription and cancer)

Overview of clinical pharmacology in cancer part 2 of 2 /

Table of Contents: “…Contents: Principles of pharmacodynamics -- Mechanisms of action of anticancer agents -- Evolution from non-specific DNA damagers to targeted therapies -- Integrated pharmacokinetics, dynamics and genomics dose response model.…”
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Mouse models to investigate cell cycle and cancer

Table of Contents: “…Contents: Cell cycle regulation during mouse development and adulthood -- Cyclin-dependent kinases (Cdks) -- The genetic pathways for cell cycle regulation -- Cdk1, Cdk2, Cdk4, and Cdk6 -- The in vivo functions of Cdk2 -- Compensation between different Cdk/cyclin complexes -- Genetic interaction between Cdk2 and Cdk4 -- Control of the G1/S phase transition by the Retinoblastoma protein (Rb) -- DNA damage response in the absence of Cdk2 -- p27Kip1 inhibits Cdk1 in vivo -- Cdk1/cyclin E complexes promote S phase -- Cdks and tumors.…”
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Endothelial cell apoptosis

Table of Contents: “…Contents: Endothelial apoptosis -- Role in tumor response to radiation therapy -- Tissue damage results from depletion of stem cells and cells with clonogenic capacity -- Radiation targets the DNA leading to reproductive (mitosis-associated) or apoptotic cell death -- Modifications of DNA damage recognition and repair pathways determine the level of tissue sensitivity to radiation -- Sphingomyelin -- Ceramide -- GI tract and bone marrow: very radiation responsive -- Growth patterns of tumors -- The two-target model for single-dose radiotherapy of experimental tumors -- Engaging the vascular component of tumor response to radiation.…”
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Gene profiling in breast cancer

Table of Contents: “…Contents: DNA microarrays and PCR can provide information about the biology of breast cancer, prediction of response and prognosis -- A molecular taxonomy of breast cancer has been proposed based on gene profiling -- Prediction of response is still inaccurate and further studies should be performed -- Several prognostic profiles have proved advantage over classical prognostic factors -- They could be used in the near future to select patients for adjuvant chemotherapy in breast cancer.…”
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Therapy in cancer 2008 quo vadis? /

Table of Contents: “…Contents: Why pursuing new therapeutic approaches in cancer is important -- Prevention and screening -- Current cancer therapy: non-surgical -- Most chemotherapy targets DNA -- Chemotherapy effects -- Current state of cancer therapy: efficacy and toxicity -- Molecular pathogenesis of cancer -- Pursuing targeted therapy in cancers -- Targeted biologic therapies -- Evolving targets and agents -- Shift from chemotherapy to targeted agents -- Clinically established molecular targets in malignancies -- Targeted therapy: proteins and small molecules -- Changes brought about by targeting: efficacy and toxicity -- Biomarkers in drug development -- What is currently known: angiogenesis -- The VEGF family and its receptors -- Bevacizumab and Sorafenib -- Does toxicity correlate with response? …”
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Endogenous bioelectrical signals in development, regeneration, and neoplasm

Table of Contents: “…Contents: Defining bioelectricity -- Sources of bioelectrical signals -- Big questions about bioelectricity -- Membrane voltage and cell plasticity -- History of the field of bioelectricity -- Applying exogenous electric fields in vitro -- Microelectrode impalement -- Detection of extracellular ion flux -- Investigating signals in pattern formation -- Inverse pharmacological screen -- Transmembrane voltage gradient characterization -- Loss- and gain-of-function analyses -- Synthesizing data into a predictive model -- Control of cell behavior by electric fields -- Mammalian stem cell differentiation -- Cell orientation and outgrowth -- Transepithelial potentials, electric fields, cancer -- Mechanisms of electric field sensing by cells -- Bioelectric signals in 3D morphogenesis -- A pathway for tail regeneration -- Transmembrane potential in tail regeneration -- V-ATPase function in tail regeneration -- Using voltage- and pH-sensitive dyes -- Induction of the V-ATPase following injury -- Electrogenic targets in mitosis upregulation -- Axon patterning requires specific ion fluxes -- Gene expression requires specific ion flows -- Ion flux and induction of regeneration -- Voltage gradients control large-scale axial polarity -- Transmembrane potential and cell behavior -- The Goldman equation -- Missexpressing specific ion transporter mRNAs -- Melanocyte behavior & transmembrane potential -- Taking advantage of endogenous ion transport -- Controlling transmembrane potential -- Modulation of transmembrane potential -- Controlling proliferation rates using K channels -- Cell-autonomous mechanisms -- Non-cell-autonomous mechanisms -- Bioelectrical signals and canonical pathways -- Bioelectric gradients and gene expression -- Information carried by bioelectric signals -- Bioelectrical mechanisms, DNA, mRNA & protein -- Control of ion flux as a master regulator -- Applications in cancer, stem cells & regeneration -- Light-gated ion transporters.…”
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