Search Results - "proteins"

Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
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Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /

Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
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Protein homeostasis in mitochondria AAA+ chaperones & proteases /

Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
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Protein stability and folding

Table of Contents: “…Contents: Protein stability -- Folding and refolding -- Molecular chaperones -- Motions within proteins -- Protein classification by function -- Protein classification by complexity.…”
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Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
Get full text
Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /

Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
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Protein homeostasis in mitochondria AAA+ chaperones & proteases /

Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
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Series

Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /

Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
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Series

Protein homeostasis in mitochondria AAA+ chaperones & proteases /

Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
Get full text
Series

Aging and protein homeostasis

Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
Get full text
Series (Autophagy and lysosomal storage diseases)
Series (Aging)

Protein stability and folding

Table of Contents: “…Contents: Protein stability -- Folding and refolding -- Molecular chaperones -- Motions within proteins -- Protein classification by function -- Protein classification by complexity.…”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
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How do proteins fold and why?

Table of Contents: “…Contents: Challenges to studying protein folding -- Methods based on hydrogen exchange (HX) -- Foldon units -- Step-wise assembly -- Building the native protein -- Error-dependent misfolding steps -- Role of chaperone molecules -- Other roles for Foldon behavior.…”
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The biogenesis of E. coli inner membrane proteins

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The biogenesis of E. coli inner membrane proteins

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The biogenesis of E. coli inner membrane proteins

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Chaperone mechanisms in cellular protein folding

Table of Contents: “…Contents: The effect of protein aggregation on productive protein folding -- The function of GroEL and GroES as a folding cage for proteins -- Changes in energy landscape within the folding cage -- Cooperation of different chaperone systems in folding pathways: Hsp70 and chaperonins -- Binding of the Hsp70 homologue protein, DnaK, to newly-synthesized polypeptides -- The role of chaperone mechanisms in toxicity suppression of misfolded disease causing proteins -- Potential uses of the chaperone mechanisms in disease therapeutics.…”
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Series (Molecular chaperones)
Series (Protein folding)

Mechanism of chaperone action of small heat shock proteins

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Molecular chaperones and handling of abnormal proteins in neurodegenerative disorders

Table of Contents: “…Contents: Aggregation of proteins associated with neurodegenerative disorders -- Mechanisms of aggresome formation -- Suppression of the heat shock response in aging and neurodegeneration -- Role of heat shock proteins in suppression of apoptosis and senescence programs.…”
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