Search Results - "DNA"

Mitochondrial DNA replication and transcription

Table of Contents: “…Contents: Introduction to the mitochondrial genetic system -- Features of mammalian mitochondrial DNA -- Characteristics of mitochondrial genetics -- Mitochondrial DNA replication: strand-displacement and strand-coupled models -- Proteins involved in mitochondrial DNA replication -- Mitochondrial DNA transcription -- Isolation and mapping of mitochondrial RNA -- Model of transcription and RNA processing -- Regulation of mtDNA expression by thyroid hormones -- Regulation of the mammalian mtDNA expression by mTERF phosphorylation.…”
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Evolution of human mitochondrial DNA variations

Table of Contents: “…Contents: Origins of mitochondria in our cells -- Functional role, size, and copy number of mitochondria -- Inheritance of mitochondrial genes -- Mitochondrial mutation rate -- Haplotypes and haplogroups -- Geographic distribution of mtDNA diversity in humans -- Natural selection and dispersals in shaping mtDNA variation -- Residence pattern effect on mtDNA diversity.…”
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Power, sex, suicide mitochondria and the meaning of life / by Lane, Nick

Subjects: An electronic book accessible through the World Wide Web; click to view

Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Mitochondrial structure and function -- Oxidative phosphorylation -- Mitochondrial DNA (mtDNA) structure, replication and maternal inheritance -- Diseases caused by mutations in mtDNA and therapy -- Diseases caused by mutations in nuclear genes coding for mitochondrial proteins.…”
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Mitochondria in reproduction and fertility part 1, mitochondria & gametes /

Table of Contents: “…Contents: Introduction to the role of mitochondria in embryonic development -- Mitochondrial life cycle, dynamics, biogenesis and mitophagy -- Mitochondria and gametes: in spermatozoa and spermatogenesis, in oocyte and oogenesis -- The bottleneck theory -- The importance of mtDNA content in oocyte competence.…”
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Mitochondria in reproduction and fertility part 2, mitochondria & embryo /

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Mitochondrial diseases an update /

Table of Contents: “…Contents: Mitochondria and mitochondrial biogenesis -- mtDNA and nucleoids -- The electron transport chain -- Epidemiology of mitochondrial diseases -- Heteroplasmy -- Mitochondrial diseases -- Adult and childhood onset of mitochondrial diseases (POLG, MELAS, LHON, KSS, Leigh syndrome) -- Treatment of mitochondrial diseases -- Mitochondrial-dysfunction related disorders.…”
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Series (Periodic reports)
Series (Mitochondrial biogenesis)

Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

Table of Contents: “…Contents: Pathogenesis of Parkinson's disease (PD) -- Mitochondria (biochemistry, DNA, proteins, turnover) -- Oxidative phosphorylation and respiratory chain -- Fraction of deleted mtDNA in substantia nigra (SN) -- Mitochondrial complex I deficiency in PD -- PARK loci -- The role of mitophagy in mitochondrial turnover -- Common pathways underlying PD pathogenesis -- Ageing and PD pathogenesis -- Autosomal mitochondrial diseases -- POLG mutations -- Alpha-synuclein (SNCA) and mitochondria -- Autophagy, lysosomal dysfunction and Glucocerebrosidase (GCase) -- Gaucher disease -- Chaperone-mediated autophagy: LAMP-2A -- GBA mutations -- DAT density and disease progression in PD -- DaTScan in genetic PD -- GCase-SNCA as a target for PD -- GBA & GBA-SNCA pathway as targets for PD therapies.…”
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Mitochondria and ageing in model systems

Table of Contents: “…Contents: Mitochondria function/dysfunction and related outcomes -- Metabolic rate theory of aging -- Beneficial effects of caloric restriction -- ROS production and oxidative stress effect on aging -- Free radical theory of aging -- Mitochondrial DNA mutations phenotypes.…”
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Mitochondrial diseases an update /

Table of Contents: “…Contents: Mitochondrial functions -- Energy generation via oxidative metabolism -- The respiratory chain -- Mitochondrial DNA (mtDNA) -- Mitochondrial genetics -- A genetic classification of the mitochondrial diseases -- Diseases due to mutations in mtDNA -- mtDNA mutations impairing mitochondrial protein synthesis -- mtDNA mutations in specific protein-coding genes -- Diseases due to mutations in nuclear DNA (nDNA) -- Mutations in nuclear genes encoding subunits of respiratory chain complexes -- Mutations in nuclear genes encoding assembly proteins -- Defects of intergenomic communications -- Defects of the inner mitochondrial membrane lipid milieu.…”
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Mitochondrial disorders and neurodegeneration

Table of Contents: “…Contents: Spectrum of mitochondrial diseases -- Mitochondrial metabolic pathway -- MtDNA mutations and disease -- Pathological features -- MELAS -- Genetic epidemiology of mtDNA mutations -- Structural components of respiratory chain complexes -- Mitochondrial DNA metabolism -- Mitochondrial proteins and oxidative phosphorylation -- Fatal mtDNA depletion syndrome -- POLG mutations -- Environmental influences on PD causation -- PARK genes -- Huntington's disease and mtDNA mutations -- Genetic basis of Friedreich's ataxia -- Mitochondrial toxins.…”
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Series (Mitochondrial biogenesis)
Series (Neurodegenerative diseases)

Mitochondrial biogenesis during gametogenesis and embryonic development

Table of Contents: “…Contents: Mitochondrial biogenesis and mass -- Mitochondrial biogenesis in spermatogenesis -- Mitochondrial biogenesis in oogenesis -- The bottleneck theory -- Maternal transmission of mitochondrial DNA -- Influence of the mitochondrial DNA content on fertilization -- Mitochondrial biogenesis in early embryonic development -- Mitochondrial transfer in reproduction.…”
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Mechanisms of mitochondrial fusion and fission

Table of Contents: “…Contents: Mitochondrial ultrastructure -- Mitochondrial organization in the cytosol -- Mitochondria-shaping proteins -- Dynamins and the dynamin superfamily -- Control of mitochondrial shape in yeast -- Control of mitochondrial morphology in mammals -- Mitochondrial fusion and the transmission of mitochondrial DNA -- Changes in mitochondrial ultrastructure during apoptosis -- Mitochondrial fragmentation during apoptosis -- Cristae remodeling and OPA1.…”
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Inborn errors of ketone body metabolism

Table of Contents: “…Contents: Ketone body metabolism -- Diagnostic approach -- Defects in ketogenesis -- Defects in ketone body utilization (succinyl-CoA:3-ketoacid CoA transferase deficiency, mitochondrial acetoacetyl-CoA thiolase deficiency) -- Molecular basis of mitochondrial acetoacetyl-CoA thiolase deficiency (protein and DNA levels).…”
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Possible roles of mitochondrial biogenesis in aging

Table of Contents: “…Contents: Oxidative phosphorylation -- The mitochondrial DNA -- Aging as the accumulation of damage -- Types of aging damage -- Types of damaged cells -- Survival of cells lacking oxidative phosphorylation -- The plasma membrane redox system -- Reductive hotspot hypothesis -- "Survival of the slowest" hypothesis -- Allotopic expression -- Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins -- Ways to make these proteins allotopically expressible.…”
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Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
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