Search Results - "proteomics"

The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Proteomic technologies and targets an overview /

Table of Contents: “…Contents: Introduction -- The relationship between genome and proteome -- Why should we analyse the proteome? -- Challenges in proteome analysis -- Dynamic range of the proteome -- Complexity of the proteome -- Spatiotemporal organisation -- Dynamic changes in protein concentrations and modifications -- Technologies for analysing the proteome -- Mass spectrometry -- Protein arrays -- Imaging -- Data analysis -- The applications of clinical proteomics -- Biomarkers -- Systems biology approaches.…”
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Proteomics of biological systems protein phosphorylation using mass spectrometry techniques / by Ham, Bryan M.

Subjects: “…Proteomics Methodology.…”
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Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
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Series (Clinical proteomics)
Series (Kidney in health and disease)

Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
Get full text
Series (Clinical proteomics)
Series (Kidney in health and disease)

Proteomic technologies and targets an overview /

Table of Contents: “…Contents: Introduction -- The relationship between genome and proteome -- Why should we analyse the proteome? -- Challenges in proteome analysis -- Dynamic range of the proteome -- Complexity of the proteome -- Spatiotemporal organisation -- Dynamic changes in protein concentrations and modifications -- Technologies for analysing the proteome -- Mass spectrometry -- Protein arrays -- Imaging -- Data analysis -- The applications of clinical proteomics -- Biomarkers -- Systems biology approaches.…”
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Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
Get full text
Series

Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
Get full text
Series (Clinical proteomics)
Series (Kidney in health and disease)

Proteomic technologies and targets an overview /

Table of Contents: “…Contents: Introduction -- The relationship between genome and proteome -- Why should we analyse the proteome? -- Challenges in proteome analysis -- Dynamic range of the proteome -- Complexity of the proteome -- Spatiotemporal organisation -- Dynamic changes in protein concentrations and modifications -- Technologies for analysing the proteome -- Mass spectrometry -- Protein arrays -- Imaging -- Data analysis -- The applications of clinical proteomics -- Biomarkers -- Systems biology approaches.…”
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Clinical proteomics in gastrointestinal cancers

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A concept for multi-marker approaches in clinical proteomics

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Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in gastrointestinal cancers

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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in gastrointestinal cancers

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