Search Results - "proteins"
Suggested Topics within your search.
Suggested Topics within your search.
- Metabolism
- metabolism 99
- Proteins 73
- Homeostasis 29
- Protein Folding 27
- Protein folding 27
- Mitochondria 24
- Ubiquitin 21
- physiology 17
- Signal Transduction 15
- chemistry 15
- drug effects 15
- genetics 15
- Cellular signal transduction 14
- Drugs 14
- Proteasome Endopeptidase Complex 14
- Drug development 13
- pharmacology 13
- Aging 12
- Mitochondrial Proteins 12
- Molecular Chaperones 12
- Pharmaceutical Preparations 12
- Pharmacogenetics 12
- diagnosis 12
- drug therapy 12
- Cancer 11
- Drug Discovery 10
- Antibacterial agents 9
- Antitubercular Agents 9
- Arylamine N-Acetyltransferase 9
-
1
Protein turnover
Published 1973Subjects: “…Proteins Metabolism Congresses.…”
An electronic book accessible through the World Wide Web; click to view
Electronic Conference Proceeding eBook -
2
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
Get full text
Series
Electronic Video -
3
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
Get full text
Series
Electronic Video -
4
Protein turnover
Published 2006Subjects: “…Proteins Metabolism.…”
An electronic book accessible through the World Wide Web; click to view
Electronic eBook -
5
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
Get full text
Series
Electronic Video -
6
Biogenesis of cellular iron-sulfur proteins part 1, structure, function, and assembly in mitochondria /
Published 2018Table of Contents: “…Contents: Structure and functions of iron-sulfur (Fe/S) clusters and proteins -- Analysis of Fe/S proteins and their biogenesis -- Mechanisms of Fe/S protein assembly in mitochondria -- Mitochondrial "Fe/S diseases."…”
Get full text
Series
Electronic Video -
7
Aging and protein homeostasis
Published 2016Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
Get full text
Series (Autophagy and lysosomal storage diseases)
Series (Aging)
Electronic Video -
8
Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
Get full text
Series
Electronic Video -
9
The unfolded protein response
Published 2012Table of Contents: “…Contents: Molecular mechanism unfolded protein response -- Physiological importance of the unfolded protein response -- Intracellular signaling from the endoplasmic reticulum (ER) to the nucleus -- Reasons for activation -- Maintenance of homeostasis of the ER.…”
Get full text
Series
Electronic Video -
10
Protein folding in vivo
Published 2012Table of Contents: “…Contents: Protein folding in vivo -- Protein folding as facilitated by the acid inducible chaperone HdeA -- Optimization of folding in vivo illustrates a tradeoff between stability and function -- The Spy chaperone.…”
Get full text
Series
Electronic Video -
11
Protein homeostasis in mitochondria AAA+ chaperones & proteases /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
Get full text
Series
Electronic Video -
12
Aging and protein homeostasis
Published 2016Table of Contents: “…Contents: Aging and protein homeostasis -- What is the role of proteotoxicity in aging? …”
Get full text
Series (Autophagy and lysosomal storage diseases)
Series (Aging)
Electronic Video -
13
Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
Get full text
Series
Electronic Video -
14
The unfolded protein response
Published 2012Table of Contents: “…Contents: Molecular mechanism unfolded protein response -- Physiological importance of the unfolded protein response -- Intracellular signaling from the endoplasmic reticulum (ER) to the nucleus -- Reasons for activation -- Maintenance of homeostasis of the ER.…”
Get full text
Series
Electronic Video -
15
Protein folding in vivo
Published 2012Table of Contents: “…Contents: Protein folding in vivo -- Protein folding as facilitated by the acid inducible chaperone HdeA -- Optimization of folding in vivo illustrates a tradeoff between stability and function -- The Spy chaperone.…”
Get full text
Series
Electronic Video -
16
Protein homeostasis in mitochondria AAA+ chaperones & proteases /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
Get full text
Series
Electronic Video -
17
Protein homeostasis in mitochondria chaperones and proteases of the mitochondrial matrix /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria: the role of chaperones and proteases -- Principles of mitochondrial protein homeostasis -- Protein quality control in the matrix compartment -- Substrate selectivity of the mitochondrial protease Pim1 -- Proteomic analysis of mitochondrial protein turnover -- Proteome alterations under oxidative stress -- Identification of aggregation-prone polypeptides -- Protective effects of chaperones -- Cooperation of Hsp78 and Pim1 in removal of aggregated polypeptides.…”
Get full text
Series
Electronic Video -
18
The unfolded protein response
Published 2012Table of Contents: “…Contents: Molecular mechanism unfolded protein response -- Physiological importance of the unfolded protein response -- Intracellular signaling from the endoplasmic reticulum (ER) to the nucleus -- Reasons for activation -- Maintenance of homeostasis of the ER.…”
Get full text
Series
Electronic Video -
19
Protein folding in vivo
Published 2012Table of Contents: “…Contents: Protein folding in vivo -- Protein folding as facilitated by the acid inducible chaperone HdeA -- Optimization of folding in vivo illustrates a tradeoff between stability and function -- The Spy chaperone.…”
Get full text
Series
Electronic Video -
20
Protein homeostasis in mitochondria AAA+ chaperones & proteases /
Published 2012Table of Contents: “…Contents: Protein homeostasis in mitochondria -- Mitochondria play an important role in ageing and disease -- Quality control of mitochondria is controlled at three different levels -- Protein quality control (PQC) in mitochondria is maintained by mitochondrial chaperones and AAA+ proteases -- Following proteotoxic stress a specific mitochondrial unfolded protein response (mtUPR) is activated -- The AAA+ protease CLPXP is proposed to play a key role in mtUPR signaling -- A novel mtCLPX interacting protein that modulates the activity of mtCLPXP both in vitro and in vivo has been identified.…”
Get full text
Series
Electronic Video