Search Results - "DNA"

DNA promise and peril / by McCabe, Linda L., 1947-

Table of Contents: “…DNA sequence does not equal destiny -- What is genomics? …”
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Mechanisms of DNA repair by recombination

Table of Contents: “…Contents: Genome instability in tumor cells -- Mutations -- Loss of heterozygozity -- Repair of chromosome breaks -- Double-strand break repair is essential for life -- Replication stalling and fragile sites -- Programmed DSBs -- Repair of DSBs arising during DNA replication by recombination -- The homologous recombination machinery -- E. coli -- Holliday junctions -- Break-induce replication -- Single strand annealing -- Types of homologous recombination -- Observing DNA repair in real time -- Molecular studies of recombination -- Nonhomologous end-joining (NHEJ) pathways -- Copy number variation -- Gene amplification.…”
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Abraham Lincoln's DNA and other adventures in genetics by Reilly, Philip, 1947-

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Mitochondrial DNA, molecular genetics and human mitochondrial diseases

Table of Contents: “…Contents: Mitochondria: structure and function -- Mitchell's chemiosmotic hypothesis -- The mammalian mitochondrial genome: replication -- Transcription -- Gene expression -- Non-Mendelian inheritance of mtDNA -- Mutations and heteroplasmy -- Mitochondrial diseases -- Reactive oxygen species and aging -- Mitochondria and neurodegenerative diseases -- The metabolic syndrome.…”
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Populations and genetics legal and socio-ethical perspectives /

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The future of CNVs sequence based resolution and links to human disease, part 1 of 2 /

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Series (Copy number variation)
Series (Biomarkers)

The future of CNVs sequence based resolution and links to human disease, (part 2 of 2) /

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Series (Copy number variation)
Series (Biomarkers)

Colorectal cancer and the rare variant hypothesis

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Mismatch repair deficient cancers diagnosis, treatment and prevention

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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Molecular medicine an introductory text / by Trent, R. J.

Table of Contents: “…History of molecular medicine -- DNA, RNA, genes and chromosomes -- Mendelian genetic traits -- Complex genetic traits -- Genomics, proteomics, and bioinformatics -- Genetic and cellular therapies -- Reproduction and development -- Infectious diseases -- Forensic medicine and science -- Ethical, legal, and social issues.…”
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Modulating gene expression to treat diseases

Table of Contents: “…Contents: Programmable DNA targeting modules -- Effector domain functions and possibilities -- Haploinsufficiency and its role in disease -- CRISPRa targeting strategy to rescue Sim1 obesity -- CRISPRa targeting strategy to treat Mc4r haploinsufficiency.…”
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A brief introduction to genetics

Table of Contents: “…Contents: The human genome -- Genome editing -- Why genetics is important today -- Gregor Mendel's pea experiments and his first law -- Applications of Mendel's first law in the context of dominant and recessive diseases in humans -- Gregor Mendel's dihybrid experiments and his second Law -- DNA fingerprinting -- Applications of Mendel's second law.…”
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The development and evolution of human gene therapy

Table of Contents: “…Contents: Background in genetic concepts -- Application by Sir Archibald Garrod to human disease -- Discovery of the structure of DNA and new opportunities to understand and manipulate genes -- Proof of principle of gene transfer into human cells using the Lesch Nyhan disease model -- Rapid expansion of clinical gene therapy trials, high level of optimism and expectation -- Major setback in human OTC gene therapy study -- Patient death -- Scientific and clinical success with another disease model -- Severe combined immunodeficiency (SCID) -- Setback in SCID -- Leukemia in some treated patients -- Additional clinical successes, especially in Leber's congenital blindness.…”
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Gene discovery for disease models

Table of Contents: “…Introduction : gene discovery-from positional cloning to genomic cloning -- High throughput gene expression analysis and the identification of expression QTLs -- DNA methylation in the pathogenesis of autoimmunity -- Ccell-based analysis with microfluidic chip -- Missing dimension : protein turnover rate measurement in gene discovery -- Bioinformatics tools for the prediction of gene function -- Determination of genomic locations of targeted genetic loci -- Mutation discovery using high throughput mutation screening technology -- Candidate screening through gene expression profile -- Candidate screening through high-density SNP array -- Gene discovery through direct genome sequencing -- Candidate screening through bioinformatics tools -- Using an integrative strategy to identify mutations -- Determination of the function of a mutant in a gene -- Confirmation of a mutation by multiple molecular approaches -- Confirmation of a mutation by microRNA -- Confirmation of function of a gene by translational approaches -- Confirmation of single nucleotide mutations -- Initial identification and confirmation of a QTL gene -- Gene discovery of crop diseases in the post genome era -- Impact of whole genome genetic element analysis on gene discovery of disease models -- Impact of whole genome protein analysis on gene discovery of disease models.…”
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Tracking vector insertion sites to explore the biology of transduced cells in vivo

Table of Contents: “…Contents: Clonal marking by integrating vectors -- Integration site analysis by LAM-PCR -- Analysis of gene therapy clinical trials for X-SCID, X-CGD, ADA-SCID & Cancer -- Avoiding oncogenesis in gene therapy -- Gene therapy for Wiskott-Aldrich Syndrome (WAS) -- Characterization & understanding of pathogenesis -- Integrations in known proto-oncogenes -- Possible triggers of AML development -- Safer vector systems & new technologies -- Lentiviral SIN-vectors -- Influence of vector type on clinical outcome -- LV integration site analysis: X-ALD trial -- Repopulation of hematopoietic system -- Targeted genome modification: nucleases -- Specificity of DNA modification by ZFN -- The TALEN nuclease and how it performs.…”
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The human genome features, variations and genetic disorders /

Table of Contents: “…Shastry -- An outlook on uterine neoplasms : from hormonal and DNA damaging to cervical and endometrial cancer development and minimally invasive management / Andrea Tinelli ... …”
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