Search Results - "DNA"

Mechanisms of DNA repair by recombination

Table of Contents: “…Contents: Genome instability in tumor cells -- Mutations -- Loss of heterozygozity -- Repair of chromosome breaks -- Double-strand break repair is essential for life -- Replication stalling and fragile sites -- Programmed DSBs -- Repair of DSBs arising during DNA replication by recombination -- The homologous recombination machinery -- E. coli -- Holliday junctions -- Break-induce replication -- Single strand annealing -- Types of homologous recombination -- Observing DNA repair in real time -- Molecular studies of recombination -- Nonhomologous end-joining (NHEJ) pathways -- Copy number variation -- Gene amplification.…”
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Inference on human history through DNA

Table of Contents: “…Contents: Human population structure -- Racial catalogs based on morphology -- Genetic variation within and between populations -- Genetic clustering of human populations -- Isolation by distance -- A recent demographic expansion from Africa -- Testing evolutionary hypotheses by coalescent simulation -- Ancient DNA.…”
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Next-generation sequencing technologies

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Mitochondrial DNA, molecular genetics and human mitochondrial diseases

Table of Contents: “…Contents: Mitochondria: structure and function -- Mitchell's chemiosmotic hypothesis -- The mammalian mitochondrial genome: replication -- Transcription -- Gene expression -- Non-Mendelian inheritance of mtDNA -- Mutations and heteroplasmy -- Mitochondrial diseases -- Reactive oxygen species and aging -- Mitochondria and neurodegenerative diseases -- The metabolic syndrome.…”
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Copy number variation

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Quantitative CNV testing in molecular diagnostics

Subjects: “…DNA Analysis. 85467…”
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The future of CNVs sequence based resolution and links to human disease, part 1 of 2 /

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Series (Copy number variation)
Series (Biomarkers)

The future of CNVs sequence based resolution and links to human disease, (part 2 of 2) /

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Series (Copy number variation)
Series (Biomarkers)

Mismatch repair deficient cancers diagnosis, treatment and prevention

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Genetics in forensics

Table of Contents: “…Contents: DNA typing in forensic analysis -- DNA fingerprinting -- Copy number variants -- Detection of minisatellites using MLPs and SLPs -- Short tandem repeats -- The DNA analysis procedure in forensics -- Advantages of mtDNA analysis over nucDNA -- Applications of mtDNA analysis -- Selecting SNPs -- Forensic validation in critical samples -- SNP typing applications -- Casework application -- DNA databases -- Statistics, interpretation and communication.…”
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Techniques utilized in molecular genetics

Table of Contents: “…Contents: Techniques utilized in molecular genetics -- Genetic material separation -- DNA isolation -- mRNA isolation -- Genetic libraries -- Cell cultures -- DNA amplification -- Polymerase Chain Reaction -- Molecular cloning -- Allele characterization -- Gel electrophoresis -- Probe hybridization -- Real time PCR -- RT-PCR: Dissociation curves -- RT-PCR: End-point analysis -- Dye-terminator DNA sequencing -- High throughput DNA sequencing.…”
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Molecular structure of the human genome

Table of Contents: “…Contents: The structure of the human genome -- Chromosomes -- Ideogram -- How is DNA organized on a micro scale -- CoT curves -- Equilibrium density gradient centrifugation -- Sequence content of the human genome -- Genes.…”
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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

A brief introduction to genetics

Table of Contents: “…Contents: The human genome -- Genome editing -- Why genetics is important today -- Gregor Mendel's pea experiments and his first law -- Applications of Mendel's first law in the context of dominant and recessive diseases in humans -- Gregor Mendel's dihybrid experiments and his second Law -- DNA fingerprinting -- Applications of Mendel's second law.…”
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Historical introduction to human diversity II

Table of Contents: “…Contents: Electrophoresis -- Electrophoretic mobility -- Amino acids -- Specific detection methods -- Detecting protein size differences -- Ioselectric focusing -- Protein polymorphism -- DNA polymorphism and electrophoresis -- Tandem repeats -- Genotype and phenotype -- Epistasis -- Isozymes -- Many proteins are encoded by multiple genes -- Multimeric proteins -- How do we know that a protein is encoded by multiple genes/alleles? …”
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The development and evolution of human gene therapy

Table of Contents: “…Contents: Background in genetic concepts -- Application by Sir Archibald Garrod to human disease -- Discovery of the structure of DNA and new opportunities to understand and manipulate genes -- Proof of principle of gene transfer into human cells using the Lesch Nyhan disease model -- Rapid expansion of clinical gene therapy trials, high level of optimism and expectation -- Major setback in human OTC gene therapy study -- Patient death -- Scientific and clinical success with another disease model -- Severe combined immunodeficiency (SCID) -- Setback in SCID -- Leukemia in some treated patients -- Additional clinical successes, especially in Leber's congenital blindness.…”
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