Search Results - "histone"

Histone dynamics, heritability and variants

Table of Contents: “…Contents: DNA is organized into chromatin which promotes compaction and brings about additional information -- The histone code hypothesis -- Chromatin dynamics and heritability -- Factors involved in chromatin dynamics -- Nucleosomes disruption and assembly following DNA replication fork passage -- General steps in chromatin assembly -- Histone chaperones and their possible roles (CAF-1, HIRA, ...) -- Histone H3 variants and chromatin assembly coupled or not with DNA synthesis -- Specific histone deposition pathways for each variant? …”
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Series (Epigenetics : concepts, theories, paradigms and mechanisms)
Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Chromatin architecture and alterations in the control of gene regulation

Table of Contents: “…Contents: The chromatin environment -- Hierarchical organization of chromatin fibers within interphase chromosomes -- Milestone experiments that linked chromatin architecture and gene expression -- Proteins and processes that influence both chromatin fiber architecture and gene expression -- Core histone N-terminal tail domains -- Core histone sequence variants -- Linker histones -- Heterochromatin proteins -- Histone post-translational modifications -- The structurally dynamic nature of the genome in vivo and its relation to gene expression.…”
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Enhancer malfunction in cancer

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DNA methylation

Table of Contents: “…Contents: Roles of DNA methylation -- Evolution of eukaryotic DNA methyltransferases -- Mechanism of action of DNA methyltransferases -- Specific loci targeting -- Histone modification -- Small interfering RNA.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Genomic insights into gene regulation by cohesin

Subjects: “…Chromosomal Proteins, Non-Histone metabolism. 104487…”
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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Epigenetic regulation of innate immunity

Table of Contents: “…Contents: The innate immune cells -- Pathogen sensing receptor system -- Histone modifications and inflammation control -- Critical role of Jmjd3, a trimethyl H3K27 specific demethylase, in M2 macrophage differentiation -- Identification of IRF4 as a Jmjd3 target gene inducing M2 macrophages.…”
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