Search Results - "prion"
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- Degeneration 3
- Genetic aspects
- Nervous system 3
- Neurodegenerative Diseases 3
- Diseases 2
- Prions 2
- genetics 2
- Alzheimer Disease 1
- Alzheimer's disease 1
- Amyloid 1
- Amyotrophic Lateral Sclerosis 1
- Amyotrophic lateral sclerosis 1
- Ataxins 1
- Disorders 1
- Genetic Predisposition to Disease 1
- Metabolism 1
- Nerve Tissue Proteins 1
- Parkinson Disease 1
- Parkinson's disease 1
- Pathology 1
- Prion Diseases 1
- Prion diseases 1
- Protein Folding 1
- Protein folding 1
- Proteins 1
- Proteostasis Deficiencies 1
- RNA-Binding Proteins 1
- RNA-protein interactions 1
- Risk Factors 1
- Tauopathies 1
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Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Electronic Video -
2
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Series
Electronic Video -
3
Neurodegenerative disease expression levels of normal sequence pathogenic proteins contribute to risk of disease /
Published 2021Table of Contents: “…Contents: Protein pathology of disease -- Loci underlying autosomal dominant neurodegenerative disease -- Prion mutations causing Gerstmann Straussler syndrome and hereditary Creuzfeldt-Jakob disease -- Tau mutations cause autosomal dominant frontal temporal dementia -- Alpha-synuclein mutations cause autosomal dominant Parkinson's disease -- How genetic variability of these genes contributes to the risk of sporadic disease.…”
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Series
Electronic Video