Search Results - "epigenetics"

Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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Epigenetics in age-related macular degeneration

Table of Contents: “…Contents: Epigenetics: terms and definitions -- Evidence for role of epigenetics in age-related macular degeneration (AMD) -- Future directions (potential for novel treatments for AMD).…”
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Epigenetic pharmaceuticals used in the clinic

Table of Contents: “…Contents: Epigenetic drugs in chemotherapy -- Selecting patients for epigenetic therapy -- Side effects of epigenetic agents -- Unique therapeutic mechanisms of epigenetic treatments -- How is epigenetic therapy applied? …”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Mental retardation and developmental delay genetic and epigenetic factors / by Smith, Moyra

An electronic book accessible through the World Wide Web; click to view

Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Biomolecular therapeutics for human cancer

Table of Contents: “…(Publisher-supplied data) Section I: Epigenetics and Cell Cycle -- Epigenetic modulation of Cell Cycle: an overview? …”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Enhancer malfunction in cancer

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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The Myc transcription factor network

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
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Omics approaches and large-scale data analysis in ageing research 1 /

Table of Contents: “…Contents: Key biogerontology questions -- Molecular signature of ageing -- Transcriptome sequencing -- RNA-seq of ageing tissues and calorie restriction -- Microarrays & Proteomics -- Epigenetic changes with age -- Other large-scale approaches -- Approaches & challenges for data analysis -- Functional enrichment -- Adaptive responses to ageing -- Plasticity of the ageing process -- Human ageing genomic resources -- GenAge database -- The genome as the digital code of life -- Genetic determinants of human longevity -- The naked mole-rat genome resource -- Sequencing the bowhead whale genome.…”
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The inherited ataxias

Table of Contents: “…-- SCA1 project overview -- Friedreich's ataxia -- Frataxin protein function -- Epigenetic factors in the pathogenesis of FRDA -- HDAC inhibition in patient with Friedreich's ataxia -- Nicotinamide in patient with Friedreich's ataxia -- Phase II open label trial of nicotinamide.…”
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Host genetic factors that limit HIV and AIDS

Table of Contents: “…Contents: Overview of candidate gene association studies of HIV and AIDS -- Key role for genetic variants involved in cell entry and host defenses -- Homozygous CCR5 32 basepair deletion prevents HIV Infection -- Acquired Immunity: HLA Class 1 proteins -- Key mediators of HIV progression -- Innate Protection: HLA and KIRS interactions in HIV disease -- Overview of Genome Wide Association Studies (GWAS) -- Overwhelming influence of HLA class I on HIV Progression and control of HIV viral load -- Non-HLA genetic associations with extreme phenotypes -- No new variants identified that prevent HIV infection -- Discovery of chromosome 22 associations with HIV-associated nephropathy -- Future studies -- Epigenetic, proteomic, functional studies -- Potential role of rare variants.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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