Search Results - "DNA"

DNA damage, mutations and aging 1 /

Table of Contents: “…Contents: Aging and longevity -- Molecular, cellular and physiological end points of DNA damage -- Can DNA damage alone cause aging? …”
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DNA damage, mutations and aging Part 2 of 2 /

Table of Contents: “…Contents: Measuring somatic mutations in humans -- How to detect mutations in normal cells, genome-wide, in humans? -- If DNA damage and mutations drive aging, why is the germline immortal?…”
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DNA repair, genetic instability, and cancer

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Aging of the genome : the dual role of DNA in life and death / by Vijg, Jan

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Aging of the genome the dual role of DNA in life and death / by Vijg, Jan

An electronic book accessible through the World Wide Web; click to view

Biomolecular therapeutics for human cancer

Table of Contents: “…The MBD4/MED1 Protein in DNA Repair, DNA Demethylation, Disease and Cancer? …”
An electronic book accessible through the World Wide Web; click to view

Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Genetic methods in the study of neurological diseases the genetic basis of neurological disorders /

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Alzheimer's disease current status of genetics research /

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Inherited neuropathies

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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Next generation sequencing in genetic diagnostics

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Epigenetics in age-related macular degeneration

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The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Genetic basis of neurological disease

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Colorectal cancer and the rare variant hypothesis

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Mismatch repair deficient cancers diagnosis, treatment and prevention

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The roles of molecular chaperones in bacterial infection

Table of Contents: “…Contents: Discovery of major molecular chaperones through the studies on bacteriophage lambda -- Discovery of function of DnaK machinery assisting assembly/disassembly of macromolecule protein structure -- Roles of DnaK chaperone machinery and ClpX chaperone in Salmonella pathogenesis and flagellar biogenesis -- Role of GroEL on bacterial cell surface.…”
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Studying aging in humans part 2 of 2, Practice /

Table of Contents: “…Contents: Examples: calorie restriction vs. the obesity paradox, inherited DNA variants and longevity.…”
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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