Search Results - "yeast"

Protein networks and analysis of global gene expression

Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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mRNA capping

Table of Contents: “…Contents: Modification of mRNA 5' ends by addition of a m7G cap structure -- Capping for viability -- Conservation in yeast to humans -- Structure of caps and capping enzymes -- Mechanism of cap synthesis -- Protein-protein interactions that link capping to events in transcription, transport and translation -- siRNA knockdown experiments.…”
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Enhancer malfunction in cancer

Table of Contents: “…Contents: MLL genes and their pathogenic translocations -- Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis -- Proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation -- What is the function of MLL? …”
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Intrinsically unstructured proteins regulation and disease /

Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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