Search Results - "proteins"
Suggested Topics within your search.
Suggested Topics within your search.
- Gene Expression Regulation
- Transcription Factors 49
- Transcription, Genetic 47
- Proteins 46
- metabolism 42
- genetics 38
- DNA 33
- Genetic regulation 29
- Eukaryotic Cells 26
- physiology 26
- Genetic transcription 20
- Gene expression 19
- Chromatin 17
- methods 17
- RNA, Messenger 15
- Genomics 12
- Epigenesis, Genetic 11
- Histones 11
- Bioinformatics 9
- Cellular signal transduction 9
- Computational biology 9
- Epigenesis 9
- Signal Transduction 9
- Genetics 8
- Protein Processing, Post-Translational 7
- Adenosine Triphosphate 6
- Calcium 6
- Calcium Channels 6
- Cell Nucleus 6
- Cell Transformation, Neoplastic 6
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1
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
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Series
Electronic Video -
2
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
Get full text
Series
Electronic Video -
3
Protein degradation
Published 2007Table of Contents: “…Contents: Protein levels in cells are regulated by their rates of synthesis and degradation -- Regulatory proteins are rapidly degraded by the ubiquitin-proteasome pathway -- Examples include many oncogenes, transcription factors and cyclins which control progress through the cell cycle -- NF-kappa B activation in disease depends on degradation of the inhibitor, I-kappa B -- Misfolded or mutant proteins are rapidly degraded -- Neurodegenerative and protein folding diseases -- Two major proteolytic pathways exist in mammalian cells -- Many acid hydrolases exist in lysosomes -- Endocytosed proteins and those in autophagic vacuoles are degraded in lysosomes -- The ubiquitin-proteasome pathway -- 3D structure of ubiquitin -- Formation of the isopeptide bonds during ubiquitin conjugation to proteins -- The ubiquitin-proteasome pathway -- Proteasome function is linked to ATP hydrolysis -- Proteasomes unfold proteins and translocate them into 20S particles -- Three types of peptidase sites -- Proposed mechanism of proteasome inhibitors -- Therapeutic applications of proteasome inhibitors -- Two systems for protein breakdown function in the two pathways for antigen presentation -- Changes in proteasome subunits induced by interferon -- Steps involved in generating antigenic peptides.…”
Get full text
Series
Electronic Video -
4
Intrinsically unstructured proteins regulation and disease /
Published 2012Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Series
Electronic Video -
5
Elongation of protein synthesis structural basis of the peptide bond /
Published 2007Subjects: Get full text
Series
Electronic Video -
6
From DNA to proteins the multiple levels of regulation /
Published 2007Table of Contents: “…Contents: General ideas behind DNA association with: histones, replication, transcription, splicing, RNA modifications, protein synthesis and death and global gene expression analysis.…”
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Series
Electronic Video -
7
Gene and protein microarrays tools for gene discovery and function /
Published 2007Table of Contents: “…Contents: High-throughput methods to examine global gene expression -- Understanding interactions in a given cell, tissue and organism under normal and disease state conditions -- Application of high throughput methods used in genomics and proteomics -- Use of DNA and protein microarrays for gene discovery and function -- Background information and terminology used in genomics and proteomics -- How DNA and protein microarrays are carried out -- Predicted future direction of genomics and proteomics microarray technologies.…”
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Series
Electronic Video -
8
Intrinsically unstructured proteins regulation and disease /
Published 2012Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Series
Electronic Video -
9
Elongation of protein synthesis structural basis of the peptide bond /
Published 2007Subjects: Get full text
Series
Electronic Video -
10
From DNA to proteins the multiple levels of regulation /
Published 2007Table of Contents: “…Contents: General ideas behind DNA association with: histones, replication, transcription, splicing, RNA modifications, protein synthesis and death and global gene expression analysis.…”
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Series
Electronic Video -
11
Gene and protein microarrays tools for gene discovery and function /
Published 2007Table of Contents: “…Contents: High-throughput methods to examine global gene expression -- Understanding interactions in a given cell, tissue and organism under normal and disease state conditions -- Application of high throughput methods used in genomics and proteomics -- Use of DNA and protein microarrays for gene discovery and function -- Background information and terminology used in genomics and proteomics -- How DNA and protein microarrays are carried out -- Predicted future direction of genomics and proteomics microarray technologies.…”
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Series
Electronic Video -
12
Elongation of protein synthesis structural basis of the peptide bond /
Published 2007Subjects: Get full text
Series
Electronic Video -
13
From DNA to proteins the multiple levels of regulation /
Published 2007Table of Contents: “…Contents: General ideas behind DNA association with: histones, replication, transcription, splicing, RNA modifications, protein synthesis and death and global gene expression analysis.…”
Get full text
Series
Electronic Video -
14
Gene and protein microarrays tools for gene discovery and function /
Published 2007Table of Contents: “…Contents: High-throughput methods to examine global gene expression -- Understanding interactions in a given cell, tissue and organism under normal and disease state conditions -- Application of high throughput methods used in genomics and proteomics -- Use of DNA and protein microarrays for gene discovery and function -- Background information and terminology used in genomics and proteomics -- How DNA and protein microarrays are carried out -- Predicted future direction of genomics and proteomics microarray technologies.…”
Get full text
Series
Electronic Video -
15
Intrinsically unstructured proteins regulation and disease /
Published 2012Table of Contents: “…Contents: Regulatory genomics and systems biology -- Intrinsically unstructured proteins (IUPs): structural and biophysical advantage -- Functional advantage -- Thermodynamic and kinetic advantage -- Conformational advantage -- Identification of IUPs -- Functions of IUPs -- Disadvantages of unstructured regions -- Unstructured regions in proteins -- Cells minimize the risks of unstructured proteins -- Tight regulation of IUPs -- Key regulatory events affecting protein availability -- IUPs in yeast -- Gene-ontology functional enrichment analysis -- Genome-scale datasets on transcript availability -- Transcripts encoding IUPs are tightly controlled -- Mechanisms affecting transcript stability -- Genome-scale datasets on protein availability -- IUPs are tightly controlled at the translational level -- PEST sequences -- Aggregation prone IUPs: more tightly regulated -- Control calculation -- Tight regulation of IUPs is evolutionarily conserved -- Control of IUP affects signaling fidelity/regulation -- Control of specific IUP affects protein aggregation.…”
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Series
Electronic Video -
16
Nucleosome dynamics and remodeling
Published 2007Table of Contents: “…Contents: Chromatin composition -- Nucleosome structure and function -- Dynamic properties inherent to nucleosomes -- Invasion of nucleosomes by gene regulatory proteins -- DNA binding proteins and enzymes -- ATP dependent remodeling factors -- Nucleosome relocation.…”
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Series
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /
Published 2017Subjects: Get full text
Series
Electronic Video -
20
Protein networks and analysis of global gene expression
Published 2007Table of Contents: “…Contents: A paradigm shift: from databases of protein sequences to protein interactions -- Technologies for measuring interactions -- Chromatin immunoprecipitation (ChIP) -- Yeast Two Hybrid (Y2H) technology -- Mass spectrometry based approaches -- Methods for querying protein networks with gene expression profiles -- Systematic validation of protein network models using gene deletions -- Cytoscape open-source software for network modeling and visualization -- Methods for network comparison across species -- Application to discover conserved protein complexes among the networks of yeast, worm, fly and Plasmodium -- Methods for querying protein networks to explain genetic (synthetic lethal) interactions -- Future directions: how network queries will enable systems biology.…”
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Series
Electronic Video