Search Results - radicalization

Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
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How trypanosomes cope with oxidative stress

Subjects: “…Free Radicals. 111873…”
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Protein oxidation and removal of oxidized proteins by proteolysis

Subjects: “…Free Radicals. 111892…”
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Exercise and free radical generation by contracting skeletal muscle

Subjects: “…Free Radicals. 111901…”
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Oxidative stress in development and neonatal diseases

Table of Contents: “…Contents: Cellular effects of oxygen radicals -- Sources of ROS -- Hyperoxia -- ROS in various processes -- ROS: good or bad? …”
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Oxidative stress in aging

Table of Contents: “…Contents: Characteristics of aging -- The decay of aging: cellular, tissue and organism level -- The longevity curves: maximum and average life span -- The theories of aging -- The free radical theory of aging -- Mitochondrial damage -- Markers of oxidative stress in aging -- Differences in oxidative stress in aging explain the differential longevity between genders -- Interventions: antioxidant vitamins, estradiol, regular exercise, caloric restriction, antioxidant enzymes.…”
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The chemistry and biochemistry of partially reduced oxygen species

Table of Contents: “…Contents: Oxy radicals and peroxides: superoxide, hydrogen peroxide, hydroxyl, peroxynitrite -- Generation by ionizing radiation and by flash photolysis -- Reactivity -- Thermodynamics, electrode potentials and kinetics -- Fenton chemistry.…”
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Lipid peroxidation from basic mechanisms to clinical relevance /

Subjects: “…Free Radicals. 112079…”
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Oxidative modification of brain proteins in Alzheimer's disease and models thereof role of amyloid beta-peptide (1-42) and insights from redox proteomics /

Subjects: “…Free Radicals. 112142…”
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Gluthatione antioxidant defense and regulation of its synthesis /

Subjects: “…Free Radicals. 112146…”
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Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species

Table of Contents: “…Contents: Reactive oxygen and nitrogen species play a critical role in physiological and pathological signaling processes -- Because of the rapid reaction between the radicals (for example, nitric oxide and superoxide), it is very difficult to detect and quantitate the formation of these species under pathophysiological conditions -- Complex interrelationship between the reactive oxygen and nitrogen species -- Importance of understanding the chemistry of the fluorophores and spin traps that are often employed in the detection of these species.…”
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The SODs

Subjects: “…Free Radicals. 112413…”
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Antioxidants and immune response and infectious diseases

Subjects: “…Free Radicals. 112438…”
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Generation of reactive oxygen species by mitochondria

Subjects: “…Free Radicals. 112442…”
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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation role in vision

Subjects: “…Free Radicals. 112452…”
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Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
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Oxidative stress in disease cardiac ischemia/reperfusion injury /

Table of Contents: “…Contents: Reperfusion injury -- Oxygen radicals are mediators of injury -- Reperfusion radical generation and duration of ischemia -- SOD1 and reperfusion -- Xanthine oxidase as a source of radical generation -- Xanthine oxidase substrates are formed during ischemia -- Superoxide and adhesion molecule expression -- Post-ischemic injury and leukocytes -- NO generation during ischemia -- NO-heme complexes in ischemic heart -- Maximizing myocardial salvage -- EPR imaging.…”
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Oxidative DNA damage mechanisms, repair and disease /

Table of Contents: “…Contents: Formation of reactive oxygen species -- Oxidative damage to DNA bases by free radicals -- Techniques used for the measurement of DNA damage and repair -- Biological responses to genomic DNA damage -- Mechanisms of base-excision repair -- Determination of substrate specificities of DNA glycosylases in-vitro and in-vivo -- Mouse and human NEIL1 proteins -- Cockayne syndrome -- CSB protein.…”
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Cell signaling by vitamin E

Table of Contents: “…Contents: Vitamin E or tocopherol's physiological molecular mechanism helps to understand protection against disease -- Not an antioxidant or free radical quencher, they perform cell signaling by affecting protein phosphorylation (for instance protein kinase C and PI3 kinase) -- They can be phosphorylated to more potent species, the tocopheryl phosphates -- Tocopheryl phosphates protect, in animal models against atherosclerosis.…”
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Peroxynitrite biochemistry oxidation and nitration reactions

Table of Contents: “…Contents: Nitric oxide reaction with superoxide radical: the formation of peroxynitrite -- Peroxynitrite-mediated thiol oxidation -- Peroxynitrite decomposition pathways: one vs two-electron oxidation processes -- Thyl radicals and sulfenic acids -- Peroxynitrite kinetics and stopped flow analysis -- Peroxynitrite reaction with fact reaction thiols, the case of peroxiredoxins -- Peroxynitrite reaction with transition metals -- The reaction of peroxynitrite with carbon dioxide: the formation of carbonate radicals -- Proton-catalyzed homolysis of peroxynitrite to hydroxyl radicals -- Lipid peroxidation and nitration -- Protein tyrosine nitration, a free radical process -- Protein tyrosine nitration in disease states -- Peroxynitrite and mitochondrial dysfunction -- Role of peroxynitrite in pathology -- Peroxynitrite therapeutics.…”
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