Search Results - "epigenetics"

Epigenetics a historical overview / by Holliday, Robin, 1932-

Table of Contents: “…Contents: Introduction to epigenetics -- the leading pioneers in the field of epigenetics -- the basic features of development -- switching and heritability of gene activities -- DNA methylation -- epimutations -- differences between genetics and epigenetics -- genomic imprinting -- chromatin structure -- histone modifications -- the role of RNA in the epigenetic regulation of gene activity -- the bisulfite sequencing technique -- the epigenotype.…”
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Cytoplasmic epigenetics proteins acting as genes /

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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Cytoplasmic epigenetics inheritance by cytoplasmic continuity /

“…Biomedical & life sciences collection. Epigenetics : concepts, theories, paradigms and mechanisms.…”
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Epigenetics in agriculture

Table of Contents: “…Contents: Climate change: a global challenge for agriculture -- Crop plasticity and genotype x environment interactions -- Molecular basis of epigenetics -- Mapping epigenetic marks and epi-alleles -- Modulation of crop development and plasticity.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…Contents: Skin structure, functions and development -- Molecular control of cell differentiation -- What is epigenetics? -- What controls variability of skin phenotypes? …”
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Epigenetics and inheritance

Table of Contents: “…Contents: Definition of epigenetics -- Epigenetics and stem cell biology -- Mechanisms of inheritable epigenetics -- Examples of the epigenetic code -- Genomic imprinting -- Imprinting as a paradigm for epigenetic gene regulation and inheritance -- Developmental Origins of Health and Disease (DOHaD) definition -- Dutch hunger winter as an example of DOHaD -- IVF as a potential example of DOHaD -- IVF technology and imprinting disorders.…”
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Introduction to epigenetics

Table of Contents: “…Contents: Definition of epigenetics -- Three mechanisms; DNA methylation, histone modification, ncRNA -- Hypo and hyper DNA methylation and association with transcriptional state -- Mechanism of DNA methylation and enzymes responsible -- Examples of importance of DNA methytransferase enzymes -- Main types of histone modifications, concentrating on acetylation and methylation -- Mechanisms and enzymes for histone modifications -- Example of gene regulation by acetylation/deacetylation in Arabidopsis -- Non-coding RNA, using X-inactivation as an example -- The histone code.…”
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Epigenetic regulation of phenotype

Table of Contents: “…-- inheritance of epigenetic marks can occur, meaning that information other than DNA sequence can be passed on from parent to offspring -- the influence of parental environmental history on an individual's epigenetic state -- does epigenetic inheritance have an adaptive value? …”
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /

“…Polycomb epigenetic mechanisms. Part 1, role of PcG complexes…”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

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Heterochromatin, epigenetics and gene expression

Table of Contents: “…Contents: Heterochromatin as a cytological phenomenon -- Heterochromatin and gene silencing -- Heterochromatin and DNA accessibility -- Histone modification and control of heterochromatin assembly -- Stability of epigenetic silencing by heterochromatin during development -- Heterochromatin and telomere stability.…”
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Series (Epigenetics, chromatin, transcription and cancer)
Series (Molecular genetics of human disease)

Epigenetics in age-related macular degeneration

Table of Contents: “…Contents: Epigenetics: terms and definitions -- Evidence for role of epigenetics in age-related macular degeneration (AMD) -- Future directions (potential for novel treatments for AMD).…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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Epigenetically mediated gene silencing a companion to genetic alterations in driving tumorigenesis /

Table of Contents: “…Contents: Introduction to epigenetic changes in cancer -- defining the process of promoter DNA hypermethylation as a constituent of a broad range of chromatin abnormalities in cancer -- defining the genes aberrantly silenced in cancer including approaches being used to screen the cancer genome for such genes -- defining what is known about the interaction of DNA methylation and chromatin modifications for initiating and maintaining gene silencing in cancer -- outlining the position of aberrant gene silencing in tumor progression and particularly highlighting the key role these changes may play for the earliest steps in tumorigenesis -- defining the potential for using DNA hypermethylated gene promoter sequences as molecular markers for cancer risk assessment, early diagnosis and prognosis -- discussing the possibilities for targeting reversal of gene silencing as a prevention and therapeutic strategy for cancer.…”
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Epigenetic regulation of innate immunity

Subjects: “…Epigenetics. 107187…”
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Epigenetic pharmaceuticals used in the clinic

Table of Contents: “…Contents: Epigenetic drugs in chemotherapy -- Selecting patients for epigenetic therapy -- Side effects of epigenetic agents -- Unique therapeutic mechanisms of epigenetic treatments -- How is epigenetic therapy applied? …”
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Evolution of mammal epigenetic control systems

Table of Contents: “…Contents: How, when and why did epigenetic silencing evolve in mammals? -- examination of two mammal-specific systems, genomic imprinting and X-chromosome inactivation, from an evolutionary standpoint, using comparisons between humans, distantly related mammals (marsupials and monotremes) and other vertebrates -- independent evolution of imprinting in different genomic regions and correlation with evolution of viviparity -- step-wise evolution of the elements of the complex X-chromosome inactivation mechanism -- shared features of imprinting and X-inactivation.…”
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Histone modifications and prospects for an epigenetic code

Table of Contents: “…Contents: Enzyme-catalyzed modification of the N-terminal tail domains of core histones provides an array of marks across the nucleosome surface and a source of epigenetic information -- This information influences protein-protein interactions during short-term regulation of ongoing transcription and is a means of maintaining or modifying patterns of gene expression from one cell generation to the next -- Cellular memory -- Histone modifications may constitute a heritable epigenetic code that acts in concert with the genetic code as a long-term regulator of gene expression.…”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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