Search Results - "proteins"
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Suggested Topics within your search.
- Diseases
- Nervous system 44
- pathology 40
- physiology 33
- Degeneration 32
- genetics 32
- Neurodegenerative Diseases 30
- metabolism 30
- Genetic aspects 24
- Physiology 19
- etiology 14
- physiopathology 14
- Amyotrophic lateral sclerosis 13
- Brain 13
- Amyotrophic Lateral Sclerosis 12
- Proteins 11
- therapy 11
- Pathophysiology 10
- Motor Neuron Disease 9
- Nervous System Diseases 9
- Protein Conformation 9
- diagnosis 9
- Age Factors 8
- Animal models 8
- Inflammation 8
- Motor neurons 8
- drug therapy 8
- immunology 8
- Alzheimer Disease 7
- Alzheimer's disease 7
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Postsynaptic scaffold proteins in health and disease
Published 2014Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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2
Postsynaptic scaffold proteins in health and disease
Published 2014Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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Series
Electronic Video -
3
Postsynaptic scaffold proteins in health and disease
Published 2014Table of Contents: “…Contents: Multi-domain structure of scaffold proteins allows multiple protein-protein interactions -- They localise important signaling proteins close to neurotransmitter receptor complexes -- Scaffold proteins at excitatory synapses underpin synaptic plasticity by regulating AMPA receptor trafficking and dendritic spine morphology -- Mutations in scaffold proteins underlie neuropsychiatric diseases such as autism and schizophrenia -- Other diseases including Alzheimers and stroke also involve mechanisms incorporating postsynaptic scaffold proteins.…”
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Electronic Video -
4
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Series
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5
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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6
Expanding roles of RNA-binding proteins in neurodegenerative diseases
Published 2017Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Series
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7
Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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8
Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Series
Electronic Video -
9
Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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10
AMPK-S6K1 signaling pathway as a target for treating hepatic insulin resistance
Published 2010Subjects: An electronic book accessible through the World Wide Web; click to view
Electronic eBook -
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The role of MAPT (Tau) in neurodegenerative disease one bullet with many triggers /
Published 2022Table of Contents: “…Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications.…”
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12
The role of MAPT (Tau) in neurodegenerative disease one bullet with many triggers /
Published 2022Table of Contents: “…Contents: Medical importance of tauopathies -- Microtubule Associated Protein Tau (MAPT) is incorporated into neurofibrillary lesions -- Mutations in the MAPT gene give rise to Frontotemporal dementia with parkinsonism (FTDP-17) -- Common variability in the MAPT, the so-called H1/H1 haplotype and sporadic tauopathies -- Progressive supranuclear Palsy and Cortico-basal degeneration -- Constitutive and conditional transgenic mouse models of tauopathy -- The JNPL3 mouse model of tauopathy -- Neurofibrillary tau pathology in the JNPL3 mice -- A-beta and MAPT pathologies can interact during the development of Alzheimer's disease -- Conditional rTg4510 model of tauopathy -- Major mechanism of neurodegeneration in tauopathy -- Potential therapeutic applications.…”
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13
Adhesion GPCRs in nervous system development and disease
Published 2019Subjects: Get full text
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14
Factor IX
Published 2007Table of Contents: “…Contents: Factor IX -- Blood coagulation -- Thrombus formation -- Factor IX gene -- Vitamin Kdependent proteins and gamma-carboxyglutamic acid -- Factor IX: biochemistry and structure -- Hemophilia B.…”
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15
The neuronal ceroid lipofuscinoses
Published 2016Table of Contents: “…Contents: Clinical features of the neuronal ceroid lipofuscinoses -- Genetics -- Genotype/phenotype correlations -- Protein epidemiology -- Mechanisms of neurodegeneration -- Treatment approaches.…”
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16
Adhesion GPCRs in nervous system development and disease
Published 2019Subjects: Get full text
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17
Adhesion GPCRs in nervous system development and disease
Published 2019Subjects: Get full text
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Mitochondrial disorders and neurodegeneration
Published 2019Table of Contents: “…Contents: Mitochondrial structure and function -- Oxidative phosphorylation -- Mitochondrial DNA (mtDNA) structure, replication and maternal inheritance -- Diseases caused by mutations in mtDNA and therapy -- Diseases caused by mutations in nuclear genes coding for mitochondrial proteins.…”
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