Search Results - "prion"

Pathogenic mechanisms in prion disease

Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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Expanding roles of RNA-binding proteins in neurodegenerative diseases

Table of Contents: “…Contents: Amyotrophic lateral sclerosis (ALS) -- Genetic causes of ALS -- Role of RNA-binding proteins and stress granules in ALS pathogenesis -- Emerging class of RNA-binding proteins with prion-like domains in neurodegenerative disease -- Mechanisms by which C9ORF72 mutations cause ALS.…”
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Clinical neuropathology text and color atlas / by Haberland, Catherine

Table of Contents: “…Basics of neuropathology -- Cerebral hypoxia -- Cerebrovascular diseases -- Neurodegenerative diseases -- Infectious diseases -- Prion diseases -- Demyelinating diseases -- Hereditary neurometabolic diseases -- Acquired neurometabolic diseases -- Tumors of the central nervous system -- Traumatic injuries of the central nervous system -- Congenital malformations of the central nervous system -- Fetal and perinatal cerebral pathology.…”
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Merritt's neurology.

Table of Contents: “…Signs and symptoms in neurologic diagnosis: approach to the patient -- Delirium and confusion -- Memory loss, behavioral changes and dementia -- Aphasia, apraxia, and agnosia -- Syncope, seizures and their mimics -- Coma -- Headache -- Diagnosis of pain and paresthesias -- Dizziness, vertigo, and hearing loss -- Impaired vision -- Involuntary movements -- Syndromes caused by weak muscles -- Gait disorders -- CT and MRI -- Electroencephalography and evoked potentials -- Electromyography, nerve conduction studies, and and magnetic stimulation -- Autonomic testing -- Neurovascular imaging -- Endovascular neuroradiology -- Lumbar puncture and cerebrospinal fluid examination -- Muscle and nerve biopsy -- Neuropsychological evaluation -- DNA diagnosis -- Bacterial infections -- Focal infections -- Viral infections and postviral syndromes -- Human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) -- Fungal infections -- Neurosarcoidosis -- Neurosyphilis -- Leptospirosis -- Lyme disease -- Parasitic infections -- Bacterial toxins -- Prion diseases -- Whipple disease -- Pathogenesis, classification, and epidemiology of cerebrovascular disease -- Examination of the patient with cerebrovascular disease -- Transient ischemic attack -- Cerebral infarction -- Intracerebral hemorrhage -- Genetics of stroke -- Other cerebrovascular syndromes -- Differential diagnosis of stroke -- Stroke in children -- Treatment and prevention of stroke -- Subarachnoid hemorrhage -- Cerebral venous and sinus thrombosis -- Vascular disease of the spinal cord -- Vasculitis -- Susac syndrome -- Vascular tumors and malformations -- Hydrocephalus -- Normal pressure hydrocephalus (NPH) -- Brain edema and disorders of intracranial pressure -- Superficial siderosis and intracerebral hypotension -- Hyperosmolar syndromes -- General considerations -- Tumors of the skull and cranial nerves -- Tumors of the meninges -- Gliomas -- Lymphomas -- Pineal region tumors -- Tumors of the pituitary gland -- Congenital and childhood tumors -- Metastatic tumors -- Spinal tumors -- Paraneoplastic syndromes -- Complications of cancer chemotherapy --…”
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