Search Results - "DNA"

DNA methylation

Table of Contents: “…Contents: Roles of DNA methylation -- Evolution of eukaryotic DNA methyltransferases -- Mechanism of action of DNA methyltransferases -- Specific loci targeting -- Histone modification -- Small interfering RNA.…”
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Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

DNA methylation in cancer

Table of Contents: “…Contents: DNA methylation in cancer -- Overview of DNA methylation in human cells -- Relationshoip of DNA methylation and chromatin structure -- Contribution of hypo/hypermethylation to tumorigenesis -- Mechanisms underlying altered DNA methylation patterns in cancer -- miRNAs as effectors and targets of aberrant DNA methylation in cancer -- Cancer methylation biomarkers -- Reversing DNA methylation in cancer therapy.…”
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Proteins that bind methylated DNA

Table of Contents: “…Contents: Introductory notions: distribution, abundance, and consequences of DNA methylation -- The methyl-binding proteins: who they are, how they were found -- What do the methyl-binding proteins do? …”
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DNA methylation, inflammation and cancer

Table of Contents: “…Contents: DNA methylation in cancer in general -- Lung cancer -- Intestinal cancer -- Inflammation -- Method for genome-wide DNA methylation profiling -- Association of the Polycomb complex with DNA methylation in inflammation and cancer.…”
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Reversing DNA methylation pharmacologically

Table of Contents: “…Contents: DNA Methylation as a target for disease therapy -- Azacitidine and Decitabine are "mechanistic" inhibitors of DNA methylation -- Clinical experience with DNA methylation inhibitors -- Translational science of biomarkers for DNA methylation inhibitor therapy -- Next generation drugs to inhibit DNA methylation.…”
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DNA methylation during development

Table of Contents: “…Contents: Methylation of CpG islands in the genome -- Un-methylated/methylated genes -- DNA methylation and gene relationship -- Methylation of transcription start sites -- Methylation motifs -- What determines methylation state? …”
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DNA methylation and stem cells

Table of Contents: “…Contents: Stem cells -- Pluripotent stem cells are extremely valuable for disease modeling and regenerative biology -- DNA methylation -- Stable epigenetic modification.…”
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DNA methylation patterns in mammals

Table of Contents: “…Contents: The distribution of cytosine methylation in mammals -- Influences on targeting of cytosine methylation -- Demethylation of DNA -- Protection against cytosine methylation -- Global and developmental dynamics of cytosine methylation -- Patterns of change of cytosine methylation in disease -- Influence of DNA sequence polymorphism on cytosine methylation variability -- Future directions.…”
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DNA methylation as a tumor marker implications for diagnosis, early detection and risk assessment /

Subjects: “…DNA Methylation. 109174…”
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Epigenetics a historical overview / by Holliday, Robin, 1932-

Table of Contents: “…Contents: Introduction to epigenetics -- the leading pioneers in the field of epigenetics -- the basic features of development -- switching and heritability of gene activities -- DNA methylation -- epimutations -- differences between genetics and epigenetics -- genomic imprinting -- chromatin structure -- histone modifications -- the role of RNA in the epigenetic regulation of gene activity -- the bisulfite sequencing technique -- the epigenotype.…”
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DNA methylation and genome defense in Neurospora crassa

Table of Contents: “…Contents: Control of DNA methylation -- repeat-induced point (RIP) mutation -- relationship of chromatin modifications and DNA methylation -- mutants that eliminate DNA methylation -- roles of histone H3 methyltransferase (DIM-5) and heterochromatin protein 1 (HP1) in DNA methylation -- indications of involvement of protein acetylation, methylation and phosphorylation in mechanism of DNA methylation -- propagation of DNA methylation and the associated silenced chromatin state.…”
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Epigenomics of complex disease

Subjects: “…DNA Methylation. 109187…”
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Genomic Imprinting

Subjects: “…DNA Methylation. 108709…”
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DNA methylation changes in aging cells and tissues

Table of Contents: “…Contents: Epigenetics -- Phenotypic variation -- DNA methylation -- Promoter CpG & Non CpG islands -- The methylome -- DNA methylation changes in aging -- Hypermethylation and silencing -- Methylation in normal colon vs. age -- Microarray analysis of aging human colon -- Methylation in aging human prostate -- Methylation vs. age in human right atrium -- MCAM analysis of aging mouse colon -- Pyro analysis of aging mouse colon -- Age related methylation along the GI tract -- Epigenetic mosaicism -- Human carcinogenesis as an epigenetic disease -- Changes in tissue function -- Tissue function consequences of DNA methylation changes in aging -- Epigenetic variation in human colon -- Susceptibility to DNA hypermethylation -- DNA hypermethylation and retrotransposons -- Genome-wide analysis of methylation proneness -- Genome architecture and the prediction of hypermethylation -- Repeat element distribution and age-related methylation -- Polycomb targets and hypermethylated genes in aging.…”
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Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

Table of Contents: “…Contents: PRC2 has an untargeted global function -- Chromatin immunoprecipitation (ChIP-seq) profiles -- H3K27 methylation -- The CBP/p300 acetylase complex -- The TRR complex (MLL3,4 in mammals) -- The DNA accessibility model -- How do PcG complexes repress? …”
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Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

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Epigenetics in age-related macular degeneration

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Introduction to epigenetics

Table of Contents: “…Contents: Definition of epigenetics -- Three mechanisms; DNA methylation, histone modification, ncRNA -- Hypo and hyper DNA methylation and association with transcriptional state -- Mechanism of DNA methylation and enzymes responsible -- Examples of importance of DNA methytransferase enzymes -- Main types of histone modifications, concentrating on acetylation and methylation -- Mechanisms and enzymes for histone modifications -- Example of gene regulation by acetylation/deacetylation in Arabidopsis -- Non-coding RNA, using X-inactivation as an example -- The histone code.…”
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Epigenetics and inheritance

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