Search Results - "yeast"

MAPK signalling regulation and cancer lessons from fission yeast /

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A novel cancer therapy to stimulate oncogenic ERK signalling

Table of Contents: “…Contents: MAPK signalling and its relevance to cancer therapy -- The discovery of ACA-28 -- The use of yeast within drug discovery -- Effect of ACA-28 on the apoptosis of cancer cells -- Implications of ACA-28 in cancer therapeutics.…”
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Computational modelling of GPCR signalling dynamics

Table of Contents: “…Contents: GPCRs signalling kinetics can be modelled using simple equations -- Link between computational modelling and pharmacology -- Yeast are excellent system for computational models -- RGS proteins show non-intuitive activity -- Kinetic models of GPCRs can model agonist bias.…”
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Dynamic signal encoding in the S. cerevisiae calcium response

Table of Contents: “…Contents: Calcium and Signaling -- Excessive calcium causes cellular stress -- Signaling pathways are turned on to combat this stress -- In budding yeast, these pathways involve nuclear translocation of transcriptional regulator Crz1 -- Examination of this regulator shows that nuclear translocation occurs in "bursts" -- Bursts are quantized and frequency-modulated -- Frequency modulation enables proportional expression of downstream target genes.…”
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