Search Results - "chromatin"

The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

Nucleosome assembly during DNA replication

Table of Contents: “…Contents: Introduction to chromatin structure -- Primary function of chromatin: DNA compaction -- The nucleosome core particle -- De novo nucleosome assembly during the cell cycle -- Two distinct processes contribute to restoration of chromatin structure during DNA replication -- A fundamental problem in nucleosome assembly: histone-DNA aggregation -- Chromatin Assembly Factor 1 (CAF-1) and PCNA -- ASF1: a multi-talented histone chaperone -- Biomedical implications -- Agents that block the acetylation and deacetylation of new histones may sensitise cells to cancer chemotherapeutic agents -- Genome-wide histone acetylation, deacetylation and epigenetic inheritance -- Epigenetic xerox machines as potential targets for cancer therapy and regenerative medicine.…”
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Nucleosome assembly during DNA replication

Table of Contents: “…Contents: Introduction to chromatin structure -- Primary function of chromatin: DNA compaction -- The nucleosome core particle -- De novo nucleosome assembly during the cell cycle -- Two distinct processes contribute to restoration of chromatin structure during DNA replication -- A fundamental problem in nucleosome assembly: histone-DNA aggregation -- Chromatin Assembly Factor 1 (CAF-1) and PCNA -- ASF1: a multi-talented histone chaperone -- Biomedical implications -- Agents that block the acetylation and deacetylation of new histones may sensitise cells to cancer chemotherapeutic agents -- Genome-wide histone acetylation, deacetylation and epigenetic inheritance -- Epigenetic xerox machines as potential targets for cancer therapy and regenerative medicine.…”
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Nucleosome assembly during DNA replication

Table of Contents: “…Contents: Introduction to chromatin structure -- Primary function of chromatin: DNA compaction -- The nucleosome core particle -- De novo nucleosome assembly during the cell cycle -- Two distinct processes contribute to restoration of chromatin structure during DNA replication -- A fundamental problem in nucleosome assembly: histone-DNA aggregation -- Chromatin Assembly Factor 1 (CAF-1) and PCNA -- ASF1: a multi-talented histone chaperone -- Biomedical implications -- Agents that block the acetylation and deacetylation of new histones may sensitise cells to cancer chemotherapeutic agents -- Genome-wide histone acetylation, deacetylation and epigenetic inheritance -- Epigenetic xerox machines as potential targets for cancer therapy and regenerative medicine.…”
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Mitotic chromosome condensation

Table of Contents: “…Contents: Evolutionary and developmental comparisons -- Stages of mitosis -- Primary functions of mitosis -- Lower levels of chromatin organization -- Helical folding -- Experimental foundation of textbook model -- Are there specific DNA sequences at the base of chromatin loops? …”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Mitotic chromosome condensation

Table of Contents: “…Contents: Evolutionary and developmental comparisons -- Stages of mitosis -- Primary functions of mitosis -- Lower levels of chromatin organization -- Helical folding -- Experimental foundation of textbook model -- Are there specific DNA sequences at the base of chromatin loops? …”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Initiation of DNA replication

Table of Contents: “…Contents: Cell cycle control of DNA replication -- Yeast as a model eukaryote -- Control of S-phase entry in yeast -- Characterization of origins of DNA replication -- Modular structure of S. cerevisiae origins -- The budding yeast origin recognition complex (ORC) -- Structure of the ORC-Cdc6 complex -- Evolutionary comparison of ORC AAA+ subunits -- Proteins required for formation of the pre-Replication Complex (pre-RC) -- Cell cycle dependent association of yeast initiation proteins with chromatin -- ATP-dependent assembly of a pre-RC -- Cell cycle regulation of the pre-RC -- The chromosome cycle and establishment of pre-RCs -- Dynamic assembly and stability of ORC in human cells -- Commitment to S-phase and initiation -- Cdc45p is associated with chromatin in a cell cycle-dependent manner -- Temporal regulation of DNA replication -- Dynamics of pre-RC proteins in human cells differ from pre-RC proteins in yeast.…”
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Mitotic chromosome condensation

Table of Contents: “…Contents: Evolutionary and developmental comparisons -- Stages of mitosis -- Primary functions of mitosis -- Lower levels of chromatin organization -- Helical folding -- Experimental foundation of textbook model -- Are there specific DNA sequences at the base of chromatin loops? …”
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Sister chromatid cohesion simple concept, complex reality /

Table of Contents: “…Contents: Sister chromatid cohesion: simple concept complex reality -- Overview of higher order chromosome structure -- Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure -- Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion -- Biological function of cohesion -- Cohesin binding to chromatin -- Establishment, maintenance and dissolution of cohesion -- The molecular basis of cohesins as chromatid tethers.…”
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Sister chromatid cohesion simple concept, complex reality /

Table of Contents: “…Contents: Sister chromatid cohesion: simple concept complex reality -- Overview of higher order chromosome structure -- Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure -- Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion -- Biological function of cohesion -- Cohesin binding to chromatin -- Establishment, maintenance and dissolution of cohesion -- The molecular basis of cohesins as chromatid tethers.…”
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Sister chromatid cohesion simple concept, complex reality /

Table of Contents: “…Contents: Sister chromatid cohesion: simple concept complex reality -- Overview of higher order chromosome structure -- Smc (structural maintenance of chromosomes) complexes as mediators of higher order chromosome structure -- Introduction to cohesin, the Smc complex that mediates sister chromatid cohesion -- Biological function of cohesion -- Cohesin binding to chromatin -- Establishment, maintenance and dissolution of cohesion -- The molecular basis of cohesins as chromatid tethers.…”
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