Search Results - "proteins"

G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
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Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

Monoclonal antibody and peptide-targeted radiotherapy of cancer

Subjects: An electronic book accessible through the World Wide Web; click to view

CML genetic paradigm of targeted therapy, part 2 of 2 /

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PI3K/AKT signaling In cancer

Table of Contents: “…Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. …”
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MAPK signalling regulation and cancer lessons from fission yeast /

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CML genetic paradigm of targeted therapy, part 1 of 2 /

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A primer on familial cancer genetics

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CML genetic paradigm of targeted therapy, part 2 of 2 /

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CML genetic paradigm of targeted therapy, part 2 of 2 /

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A primer on familial cancer genetics

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PI3K/AKT signaling In cancer

Table of Contents: “…Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. …”
Get full text
Series

PI3K/AKT signaling In cancer

Table of Contents: “…Contents: PI3K/AKT signal transduction pathway -- Tumors with frequent dysregulation of PI3K signalling -- Modalities for inhibiting PI3K-AKT signaling currently in development -- AKT1/2 inhibitor (Merck) -- PI3K/AKT in breast cancer -- AKTi-1/2 inhibits AKT signaling and causes G1 arrest -- The Herceptin-resistant -- Effect of AKT inhibition on glucose levels -- Mutated elements in mitogenic signaling pathways in tumors -- Coexistent K-Ras or B-Raf mutation -- Genes encoding several components of mitogenic signaling pathways are mutationally activated in tumors -- Integrators of multiple signaling pathways (OR-gates) -- The effects of combined inhibition of AKT and MAPK on the phosphorylation of translational regulatory proteins -- Knockdown of 4EBP1 expression -- Feedback inhibition of insulin/IGF-1 signaling -- The concept of feedback -- Clinical effects of Rapamycin-like drugs -- mTORC1 vs. …”
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MAPK signalling regulation and cancer lessons from fission yeast /

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