Search Results - "histone"

Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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