Search Results - "epigenetics"

Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
Get full text
Series

Epigenetic pharmaceuticals used in the clinic

Table of Contents: “…Contents: Epigenetic drugs in chemotherapy -- Selecting patients for epigenetic therapy -- Side effects of epigenetic agents -- Unique therapeutic mechanisms of epigenetic treatments -- How is epigenetic therapy applied? …”
Get full text
Series

Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
Get full text

Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
Get full text

Biomolecular therapeutics for human cancer

Table of Contents: “…(Publisher-supplied data) Section I: Epigenetics and Cell Cycle -- Epigenetic modulation of Cell Cycle: an overview? …”
An electronic book accessible through the World Wide Web; click to view

Role of polycomb proteins in gene transcription, stem cell and human diseases

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
Get full text
Series

The Myc transcription factor network

“…Biomedical & life sciences collection. Epigenetics, chromatin, transcription and cancer.…”
Get full text
Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

O-GlcNAc, an essential regulator of numerous cellular pathways

Table of Contents: “…Contents: O-GlcNAc -- A Novel Intracellular Glycan -- Biosynthesis of O-GlcNAc -- Mechanisms by which O-GlcNAc regulates proteins -- Cellular pathways and diseases regulated by O-GlcNAc -- Epigenetics and transcription -- Translation -- Cell cycle -- Nutritional sensing -- Neurodegeneration -- Cancer -- The cellular stress response.…”
Get full text
Series

Cancer stem cells

Table of Contents: “…Contents: Introduction to normal and cancer stem cell (CSCs) -- Leukemia CSCs -- Solid tumor CSCs -- Possible origin of CSCs -- Functional assays for CSCs -- Conversion of non-CSCs to CSCs -- Epithelial-mesenchymal transition (EMT) -- CSC plasticity and heterogeneity -- Signaling and epigenetic regulators of CSCs -- CSC niche -- Role of CSCs in therapeutic resistance -- Strategies for targeting CSCs.…”
Get full text
Series

Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
Get full text
Series

Vitamin C : new biochemical and functional insights /

Table of Contents: “…IVC as multi-target anti-cancer agent. IVC and epigenetics. IVC in hypoxia. Overview of recent clinical trials. …”
Taylor & Francis
OCLC metadata license agreement