Search Results - "DNA"

DNA repair, genetic instability, and cancer

Subjects: An electronic book accessible through the World Wide Web; click to view

Biomolecular therapeutics for human cancer

Table of Contents: “…The MBD4/MED1 Protein in DNA Repair, DNA Demethylation, Disease and Cancer? …”
An electronic book accessible through the World Wide Web; click to view

Epigenetic biomarkers in cancer

Table of Contents: “…Contents: Epigenetics -- levels of control -- The patient cancer journey-multiple impact points -- Key translational areas for epigenetics -- DNA methylation as cancer biomarker -- DNA methylation analysis methods -- Epigenetic gene silencing in malignant cells -- CpG methylation and clinical outcome -- Causes of aberrant DNA methylation in cancer -- Stem cell targets -- EZH2 as a potential anti-cancer target -- Epigenetic modification as drug targets -- Epigenetic therapies -- DNA methylation versus platinum resistance -- Phase II trial of Decitabine & Carboplatin -- Effects of low doses of DNA-demethylation agents -- Epigenetic therapies challenges.…”
Get full text
Series

Virology and cancer biology part 2, DNA viruses associated with transformation and tumor formation : the discovery of tumor suppressor genes /

Table of Contents: “…Contents: DNA viruses and transformation -- Viral T antigen and cell cycle control -- The linkage between Cell cycle, T antigens, Rb, E2F and p53 -- Transformation as an epiphenomenon of DNA viruses.…”
Get full text
Series

O-GlcNAc, an essential regulator of numerous cellular pathways

Subjects: Get full text
Series

Role of polycomb proteins in gene transcription, stem cell and human diseases

Subjects: Get full text
Series

The Myc transcription factor network

Table of Contents: “…Contents: Myc plays a broad role in cellular functions -- Deregulation of Myc is associated with many cancers -- Myc and Mxd proteins heterodimerize with Max, bind DNA, and activate or repress transcription through recruitment of co-regulator complexes that in turn influence chromatin modifications -- Myc family proteins are highly conserved and regulate cell growth by binding to many genes involved in translation and metabolism -- Myc also has functions unrelated to transcription -- Update talk: The MYC transcription factor network -- Update talk: Interactions of MYC with other cellular proteins -- Update talk: Topologically Associated Domains (TADs) -- Update talk: Transcriptional functions of MYC -- Update talk: Proximal MYC network -- Update talk: New approaches to inhibiting MYC activity.…”
Get full text
Series (Cell division cycle)
Series (Epigenetics, chromatin, transcription and cancer)

Overview of clinical pharmacology in cancer part 2 of 2 /

Table of Contents: “…Contents: Principles of pharmacodynamics -- Mechanisms of action of anticancer agents -- Evolution from non-specific DNA damagers to targeted therapies -- Integrated pharmacokinetics, dynamics and genomics dose response model.…”
Get full text
Series

Mouse models to investigate cell cycle and cancer

Table of Contents: “…Contents: Cell cycle regulation during mouse development and adulthood -- Cyclin-dependent kinases (Cdks) -- The genetic pathways for cell cycle regulation -- Cdk1, Cdk2, Cdk4, and Cdk6 -- The in vivo functions of Cdk2 -- Compensation between different Cdk/cyclin complexes -- Genetic interaction between Cdk2 and Cdk4 -- Control of the G1/S phase transition by the Retinoblastoma protein (Rb) -- DNA damage response in the absence of Cdk2 -- p27Kip1 inhibits Cdk1 in vivo -- Cdk1/cyclin E complexes promote S phase -- Cdks and tumors.…”
Get full text
Series

Colorectal cancer and the rare variant hypothesis

Subjects: Get full text
Series

The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
Get full text
Series

Mismatch repair deficient cancers diagnosis, treatment and prevention

Subjects: Get full text
Series

The molecular biology of cancer

Table of Contents: “…Introduction / Stella Pelengaris, Mike Khan -- The burden of cancer / William Steward, Anne Thomas -- Nature and nurture in oncogenesis / Stella Pelengaris, Mike Khan -- DNA replication and the cell cycle / Stella Pelengaris, Mike Khan -- Regulation of growth : growth factors, receptors and signaling pathways / Stella Pelengaris, Mike Khan -- Oncogenes / Stella Pelengaris, Mike Khan -- Tumour suppressor genes / Martine Roussel -- Apoptosis / Stella Pelengaris, Mike Khan -- Telomeres and senescence / Maria Blasco, Mike Khan --…”
An electronic book accessible through the World Wide Web; click to view

Advancements in cancer research

Table of Contents: “…An outlook on uterine neoplasms : from hormonal and DNA damaging to cervical and endometrial cancer development and minimally invasive management / Andrea Tinelli ... …”
An electronic book accessible through the World Wide Web; click to view