Search Results - "prion"
Suggested Topics within your search.
Suggested Topics within your search.
- Brain
- Degeneration 3
- Nervous system 3
- Neurodegenerative Diseases 2
- metabolism 2
- Aging 1
- Alzheimer Disease 1
- Alzheimer's disease 1
- Amyloid beta-Peptides 1
- Amyloid beta-protein 1
- Chemotherapy 1
- Diagnosis 1
- Etiology 1
- Health aspects 1
- Metabolism 1
- Metals 1
- Molecular aspects 1
- Neurons 1
- Oxidative stress 1
- Pathogenesis 1
- Pathophysiology 1
- Proteasome Endopeptidase Complex 1
- Proteasome Inhibitors 1
- Protein Folding 1
- Protein folding 1
- Proteins 1
- Proteolysis 1
- Ubiquitin 1
- chemistry 1
- drug therapy 1
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Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies /
Published 2014Table of Contents: “…Brain function, physiology, and the blood-brain barrier -- Role of metal ions in brain function, metal transport, storage, and homeostasis -- Immune system and neuroinflammation -- Oxidative stress in neurodegenerative diseases -- Aging and mild cognitive impairment, MCI -- Parkinson's disease -- Alzheimer's disease -- Huntington's disease and polyglutamine expansion neurodegenerative diseases -- Friedreich's ataxia and diseases associated with expansion of non-coding triplets -- Creutzfeldt-Jakob and other prion diseases -- Amyotropic lateral sclerosis -- Alcoholic brain damage -- Other neurological diseases -- Therapeutic strategies to combat the onset and progression of neurological diseases.…”
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Protein degradation and defense against neurodegenerative disease part 2 of 2 /
Published 2014Table of Contents: “…Contents: The 26S proteasome -- The 20S proteasome -- Proteasome inhibitors -- PS-341 -- Proteasome inhibitors in multiple myeloma -- Structures of the archaeal PAN ATPase-20S complex and the eukaryotic 26S proteasome -- Multiple ATP-dependent steps in proteasome function -- The gating mechanism of the proteasome -- Prions inhibit proteasome function -- Binding of ubiquitin conjugates activate the 26S proteasome by stimulating 20S gate-opening and ATP hydrolysis -- Ubiquitin conjugates activate their own degradation by the 26S Proteasome -- The inhibitor of proteasome-associated deubiquitinating enzyme Usp14, IU1, enhances degradation of tau.…”
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3
Targeting Aß oligomers a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease /
Published 2014Table of Contents: “…Contents: The oligomer cascade hypothesis for Alzheimer's Disease -- Why the oligomer hypothesis has largely supplanted the amyloid cascade hypothesis -- The role of AβOs in memory failure and the major facets of AD neuropathology -- Mechanisms by which AβOs instigate neurotoxicity -- Why AβOs accumulate in the first place -- How AβOs offer superb targets for novel AD diagnostics and disease-modifying therapeutics -- Beside its direct link to Alzheimer's disease, the discovery of toxic Aβ oligomers has provided a novel structural archetype for toxins germane to more than two dozen diseases of protein mis-folding, including Diabetes, Parkinson's, and prion diseases.…”
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Electronic Video