Search Results - Cancer

Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
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Circulating nucleic acids as biomarkers in cancer patients

Table of Contents: “…Tumor Tissue DNA -- Circulating DNA in patients with benign disease and malignant tumors -- Circulating microRNAs in cancer patients -- Associations between Circulating Tumor Cells and cell-free tumor DNA in cancer patients.…”
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Role of molecular markers in guiding therapy in cancer

Table of Contents: “…Contents: Prognostic biomarkers in breast cancer -- Microsatellite instability (MSI) in colon cancer -- Markers for metastatic germ cell cancers -- Systemic treatments for cancer therapies -- Therapy predictive markers -- Toxicity markers -- Determining treatment effectivity -- Caveats in use of markers in therapy -- Current vs. future approach to cancer management.…”
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Mismatch repair deficient cancers diagnosis, treatment and prevention

Table of Contents: “…Contents: Lynch syndrome (underlying single gene defect) -- Microsatellites -- Important genes containing repeat sequences -- MSI testing (5 marker panel) -- Mismatch repair (MMR) -- The genomic pathogenesis of colorectal cancer (CRC) -- EGFR and BRAF mutant inhibition -- BRAF colon cancer project -- Methotrexate & MMR deficient tumours -- Africans & bowel cancer (Dennis Burkitt) -- Cancer prevention program (CaPP) -- NSAIDs and reduced colorectal cancer risk -- Aspirin effect on polyps in FAP and colorectal adenoma -- The prevention paradox -- CaPP2 (Colorectal & Lynch syndrome cancers) -- Meta-analysis of cancer deaths with aspirin treatment -- CRCs in people on aspirin (mostly COX2 negative) -- Individual response to aspirin in cancer prevention -- History of salicylate as an essential nutrient -- CaPP3 study -- Peptides created by slippage in microsatellite coding -- Antibodies as a possible biomarker for Lynch syndrome -- The Micoryx vaccine.…”
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Biomarkers in oncology overview /

Table of Contents: “…Contents: Tumor biomarkers -- Role of tumor biomarkers in cancer screening -- Aiding cancer diagnosis -- Determining prognosis -- Therapy prediction -- Post-operative surveillance -- Monitoring therapy in advanced disease.…”
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Surrogate endpoints of efficacy

Table of Contents: “…Contents: Improvement in overall survival must be considered the single most important goal of any new antineoplastic strategy -- Also increasingly recognized that in well-defined settings it is reasonable to employ other objectively measurable endpoints of efficacy such as time to symptomatic disease progression -- The rationale for the use of surrogate or alternative endpoints in cancer clinical trials -- Examples of where such endpoints may be appropriately utilized.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Arylamine N-acetyltransferases part 2 of 3 /

Table of Contents: “…Contents: Mechanism of action -- Reaction substrates -- Isoform substrate profiles -- Isoenzymes NAT1 and NAT2 -- Regulation of gene expression -- Pharmacogenetics -- Phenotype/genotype correlation -- Ethnic variation -- Transgenic mouse models -- NAT protein structures -- NAT as a biomarker in breast cancer -- NAT inhibitors as diagnostic agents -- NAT in mycobacteria -- NAT inhibitors as an approach to potential anti-tubercular agents.…”
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Arylamine N-acetyltransferases part 3 of 3 /

Table of Contents: “…Contents: Mechanism of action -- Reaction substrates -- Isoform substrate profiles -- Isoenzymes NAT1 and NAT2 -- Regulation of gene expression -- Pharmacogenetics -- Phenotype/genotype correlation -- Ethnic variation -- Transgenic mouse models -- NAT protein structures -- NAT as a biomarker in breast cancer -- NAT inhibitors as diagnostic agents -- NAT in mycobacteria -- NAT inhibitors as an approach to potential anti-tubercular agents.…”
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Arylamine N-acetyltransferases part 1 of 3 /

Table of Contents: “…Contents: Mechanism of action -- Reaction substrates -- Isoform substrate profiles -- Isoenzymes NAT1 and NAT2 -- Regulation of gene expression -- Pharmacogenetics -- Phenotype/genotype correlation -- Ethnic variation -- Transgenic mouse models -- NAT protein structures -- NAT as a biomarker in breast cancer -- NAT inhibitors as diagnostic agents -- NAT in mycobacteria -- NAT inhibitors as an approach to potential anti-tubercular agents.…”
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EGFR inhibitors in NSCLC and the role of biomarkers for selection of patients

“…Biomedical & life sciences collection. Cancer therapy : latest thinking in efficacy and toxicity.…”
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