Search Results - "proteomics"

The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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The proteomic revolution

Table of Contents: “…Contents: The proteomic revolution -- Proteomics is the best measure of phenotype (biomarkers) -- Slow Off-rate Modified Aptamers (SOMAmers) are breakthrough protein binding reagents -- SOMAmers are multiplexed to perform SOMAscan assay, which measures >1000 proteins in small sample volumes using DNA measurement tools to identify and quantify proteins bound by SOMAmers -- Applications of SOMAscan to date include finding valid protein biomarkers for lung cancer, cardiovascular risk, pre-term birth, pancreatic cancer, mesothelioma, and many other diseases and conditions -- Ability to do comprehensive longitudinal proteomics studies will revolutionize medicine.…”
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Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
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Series (Clinical proteomics)
Series (Kidney in health and disease)

Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
Get full text
Series (Clinical proteomics)
Series (Kidney in health and disease)

Proteomics in cardiovascular disease clinical considerations /

Table of Contents: “…Contents: Systems biology -- Definition of proteomics -- Proteomics: rationale and practical aspects -- Proteomics in cardiovascular pathophysiology -- Proteomics to detect biomarkers of cardiovascular disease -- Urinary proteomics using capillary electrophoresis / mass spectrometry -- Proteomics of coronary artery disease -- Proteomics of pre-eclampsia -- Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy.…”
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Series

Proteomics in kidney disease clinical considerations /

Table of Contents: “…Contents: Proteomics for clinical use -- Available and applied single risk marker strategies in nephrology based on hypothesis driven biomarker search -- Open or unbiased multimarker approaches including plasma and urine proteomics -- Examples from different renal diseases -- Data from cross sectional and longitudinal studies -- Proteomics may provide insight into disease pathology -- Proteomics may provide risk stratification for clinical trials -- Example: intervention trial for type 2 diabetic subjects with high risk urinary proteomic pattern.…”
Get full text
Series (Clinical proteomics)
Series (Kidney in health and disease)

A concept for multi-marker approaches in clinical proteomics

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Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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Clinical proteomics in neurodegenerative disease

Table of Contents: “…Contents: Neurodegenerative disease -- Dementia -- Alzheimer´s -- Clinical use of proteomic methods for diagnosis and biomarker development -- An example: CE-MS in Alzheimer research -- Scope, limits, pitfalls, prospects.…”
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A concept for multi-marker approaches in clinical proteomics

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A concept for multi-marker approaches in clinical proteomics

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Urinary proteomics in kidney and cardiovascular disease

Table of Contents: “…Contents: Omics technologies -- Technology platforms: (2DE-MS, LC-MS-MS, CE/MS) -- Clinical proteomics -- Precision as a function of no. of markers -- Human urinary LMW proteome database -- Requirements for biomarker selection -- How to identify valid proteomic biomarkers -- Effect size estimation and the number of samples -- Erroneous biomarkers -- Classification using different sizes of training sets -- Classification errors -- CKD biomarkers -- Biomarker validation -- Pathophysiological suggestions -- Selected urinary peptides and CKD staging -- Multicentric European PRIORITY trial -- Proteomics of coronary artery disease and of diabetic nephropathy.…”
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Series (Clinical proteomics)
Series (Kidney in health and disease)

Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
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Urinary proteomics in kidney and cardiovascular disease

Table of Contents: “…Contents: Omics technologies -- Technology platforms: (2DE-MS, LC-MS-MS, CE/MS) -- Clinical proteomics -- Precision as a function of no. of markers -- Human urinary LMW proteome database -- Requirements for biomarker selection -- How to identify valid proteomic biomarkers -- Effect size estimation and the number of samples -- Erroneous biomarkers -- Classification using different sizes of training sets -- Classification errors -- CKD biomarkers -- Biomarker validation -- Pathophysiological suggestions -- Selected urinary peptides and CKD staging -- Multicentric European PRIORITY trial -- Proteomics of coronary artery disease and of diabetic nephropathy.…”
Get full text
Series (Clinical proteomics)
Series (Kidney in health and disease)

Clinical proteomics in the investigation of bladder cancer

Table of Contents: “…Contents: Clinical proteomics: principles of experimental design and data reporting -- Clinical needs in bladder cancer -- Bladder Cancer Biomarker discovery in urine using proteomics approaches -- How to progress towards implementation.…”
Get full text
Series