Search Results - "prion"
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Suggested Topics within your search.
- Prions 20
- Amyloid 16
- Prion diseases 12
- Nervous system 11
- Neurodegenerative Diseases 10
- Degeneration 9
- Prion Diseases 7
- Protein Folding 6
- metabolism 5
- Diseases 4
- Protein folding 4
- Proteins 4
- pathology 4
- Alzheimer Disease 3
- Alzheimer's disease 3
- Brain 3
- Diagnosis 3
- Genetic aspects 3
- Protein Conformation 3
- Safety measures 3
- etiology 3
- genetics 3
- Chemotherapy 2
- Dementia 2
- Food 2
- HSP40 Heat-Shock Proteins 2
- History 2
- Infections 2
- Metabolism 2
- Molecular chaperones 2
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Prions and prion diseases new developments /
Published 2012Subjects: “…Prion diseases.…”
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2
Prion diseases
Published 2007Table of Contents: “…Contents: Normal function of prion protein -- Prion diseases -- Mechanism of propagation of PrP -- Propagation in acquired and familial forms -- Pathogenic hypothesis -- Human pathogenic mutation and polymorphisms -- Laboratory methods -- Epidemiology -- Sporadic prion diseases -- New variant CJD -- Treatment of prion disease.…”
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3
Prion diseases
Published 2007Table of Contents: “…Contents: Understanding the biophysical aspects of a disease of protein misfolding -- Structural studies of PrPc and PrPsc -- The development of synthetic mammalian prions and the proof of their infectivity and serial transmissibility -- Heterocyclic pharmacotherapies for prion disease -- Pyridinyl based therapies and structure based design -- Serendipitous discovery of acridines as anti-prion agents -- Bisacridines as potent inhibitors of prion replication in cell culture -- The relationship between the prion diseases and other diseases of protein misfolding.…”
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4
Chaperones and prions
Published 2020Table of Contents: “…Contents: Prion diseases -- Prions as self-propagating amyloids -- Yeast prions as protein-based heritable elements -- Prion detection -- Crucial role of the chaperone protein Hsp104 in the propagation of yeast prions -- Chaperone-mediated fragmentation turns amyloids into infectious or heritable prions -- Effects of the Hsp70 and Hsp40 proteins on yeast prions -- Other modulators of prion formation and propagation: cytoskeleton and ubiquitin system.…”
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5
Prions and amyloids introduction /
Published 2008Table of Contents: “…Contents: Definitions of prions and amyloid -- Genetic criteria for a prion -- Prions of mammals, yeast and filamentous fungi -- Prion domains -- Non-amyloid prions.…”
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6
Advancing prion science guidance for the national prion research program /
Published 2004Table of Contents: “…Executive summary -- Prion diseases: an overview -- Diagnostics for transmissible spongiform encephalopathies -- Testing blood for evidence of transmissible spongiform encephalopathies in the United States -- Assessment of strategies to prevent and treat transmissible spongiform encephalopathies -- Infrastructure for research on transmissible spongiform encephalopathies -- Risks of transmissible spongiform encephalopathies to the U.S. military.…”
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7
Prions in humans and animals
Published 2007Subjects: “…Prion diseases.…”
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8
Advancing prion science guidance for the National Prion Research Program, interim report /
Published 2003Subjects: “…Prion diseases Research United States.…”
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9
Prion biology and diseases
Published 1999Subjects: “…Prions.…”
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10
How the cows turned mad
Published 2003Subjects: “…Prion diseases History.…”
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11
Fatal flaws how a misfolded protein baffled scientists and changed the way we look at the brain /
Published 2013Subjects: “…Prions.…”
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12
Yeast and fungal prions a help or a hindrance? /
Published 2008Table of Contents: “…Contents: [URE3] and [PSI+] not found in wild strains indicating they are harmful -- [Het-s] may benefit its host or may result from "meiotic drive" -- Some "prion domains" cannot be prions -- "Prion domains" have non-prion functions -- Rapid evolution of prion domains may protect against infection.…”
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13
[PIN+] prions beget prions /
Published 2008Table of Contents: “…Contents: Prions are infectious proteins -- [PIN+] is a prion of Rnq1 - [PIN+] exists as different variants -- Prions can affect the stability of other variants of the same prion, or of heterologous prions.…”
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14
How the cows turned mad unlocking the mysteries of mad cow disease /
Published 2004Subjects: An electronic book accessible through the World Wide Web; click to view
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15
Mechanism of prion generation in vitro
Published 2020Table of Contents: “…Contents: Prion propagation in vitro requires PrP plus an incorporated polyanion -- PrPC post-translational modifications influence prion formation -- Zinc and copper inhibit PrPSc amplification.…”
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16
Pathogenic mechanisms in prion disease
Published 2014Table of Contents: “…Contents: Neurodegenerative diseases and protein misfolding disorders -- Prion disease in mice to study mechanisms of neurodegeneration due to misfolded protein accumulation -- Early prion neurodegenerative change is reversible: access to key neurotoxic pathways -- Critical change is loss of synaptic proteins due to activation of PERK branch of the unfolded protein response -- Modifying this pathway genetically is neuroprotective -- Modifying this pathway pharmacologically is neuroprotective -- Relevance of this pathway in other neurodegenerative diseases with misolded proteins e.g. …”
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17
Mechanisms of yeast prion propagation
Published 2008Table of Contents: “…Contents: Prions as infectious amyloids -- Yeast [PSI+] prion and Sup35p -- Molecular chaperone Hsp104 -- Guanidine hydrochloride as a prion propagation inhibitor -- Propagons -- Estimating propagon numbers using a stochastic model -- Generation of new propagons -- Propagation-defective mutants (PNM) -- Role of primary sequence information -- Yeast prion propagation: the unanswered questions.…”
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18
Yeast prions and protein chaperones a help or a hindrance? /
Published 2008Table of Contents: “…Contents: Role of protein chaperones in protein folding -- Yeast prions as amyloid forms of cellular proteins -- Requirement of chaperone machinery for prion propagation -- Chaperone mutants adversely affect prions and provide insight into chaperone/amyloid interactions.…”
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19
The genetics and biology of the [Het-s] prion of Podospora
Published 2008Table of Contents: “…Contents: Mammalian prions -- Fungal prions -- Yeast: [URE3], [PSI+] and [PIN+] -- Filamentous fungi: [Het-s] -- Fungal self non-self recognition -- Heterokaryon incompatibility -- Genetics of [Het-s] -- Maternal inheritance -- Meiotic drive -- In vivo and in vitro aggregation of HET-s protein -- Role of the Hsp104 chaperone in [Het-s] system -- Role of the Hsp104 chaperone in [Het-s] prion propagation -- Podospora anserine.…”
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20
Prion-like propagation of Parkinson's disease
Published 2014Table of Contents: “…Contents: Parkinson's disease : symptoms and pathology (PD mutations and risk factors) -- Braak staging of Lewy body-related pathology in PD -- The prion-like hypothesis -- Key steps of alpha-synuclein pathology propagation (Release, Uptake, Seeding, Transport) -- In vivo and cell models from different species -- Therapeutic targets: promoting degradation, antibody aided clearance, and preventing seeding of alpha-synuclein -- Parkinson's disease vaccine: first clinical studies.…”
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