Search Results - Stem cells

Stem cells immortality or healthy old age? /

Table of Contents: “…Contents: What is a stem cell? -- Properties of stem cells -- Adult and embryonic stem cells -- What is immortality? …”
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Stem cell memory

Table of Contents: “…Contents: Defining stem cell memory -- Deterministic asymmetric self-renewal evidence -- Two classes of adult stem cell memory -- The genetic fidelity problem -- Chromosome segregation vs. co-segregation -- Asymmetric self-renewal models -- Biochemical control of asymmetric self-renewal -- Potential molecular elements -- ASRA gene signature discovery -- Properties of H2A.Z.…”
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Stem cell ethics

Table of Contents: “…Contents: Stem cell biology -- Therapeutic possibilities -- Ethical concerns -- Personal ethics -- Research ethics -- Moral status of human embryo -- "Spare" embryos -- Research embryos -- Nuclear transfer embryos -- Legal situation in different countries -- Social ethics.…”
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Cartilage stem cells tools for joint repair? /

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Commercialisation of stem cells

Table of Contents: “…Contents: Why use stem cells? -- The IP problems of commercializing stem cell research -- Ethics and commercialization -- Selecting stem cells for commercial development -- Producing cells for product development -- Scale-up and quality issues -- The promise of automation -- Developing a product -- Lung disease: the medical need and the approach -- Simplifying the strategy by simplifying the product -- R&D of a lung assist device for lung therapeutics -- The key lesson for commercial development.…”
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Stem cells and medicine

Table of Contents: “…Contents: Types of stem cells: embryonic or pluripotent, somatic, fetal vs. adult -- Are stem cells a threat or a benefit? …”
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Stem cell bioprocessing

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Drosophila stem cells

Table of Contents: “…Contents: Lineage tracing -- Stem cell niches -- Germline stem cell niche in ovary -- Germline stem cell niche in testis -- Dedifferentiation -- Stem cell signaling back to the niche -- Intestinal stem cells -- Stem cell chromatin.…”
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Hematopoietic stem cells the power of clonal assays /

Table of Contents: “…Contents: The haematopoietic process -- Spleen colony assay -- Colony forming assay -- Competition repopulation assay -- Haematopoietic stem cell subtypes and leukemia -- Index sorting experiments and the identification of a molecular overlap -- Assessing somatic mutations within HSC colonies -- Recapture experiments -- Inferring HSC population size.…”
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Cancer stem cells

Table of Contents: “…Contents: Introduction to normal and cancer stem cell (CSCs) -- Leukemia CSCs -- Solid tumor CSCs -- Possible origin of CSCs -- Functional assays for CSCs -- Conversion of non-CSCs to CSCs -- Epithelial-mesenchymal transition (EMT) -- CSC plasticity and heterogeneity -- Signaling and epigenetic regulators of CSCs -- CSC niche -- Role of CSCs in therapeutic resistance -- Strategies for targeting CSCs.…”
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Hematopoietic stem cells and progenitor cells, their role in normal blood formation part 1 of 2 /

Table of Contents: “…Contents: Definition of stem cells -- Hematopoietic stem cell -- Hematopoietic and progenitor cell lineages (Weissman model) -- Hematopoiesis: alternative model -- Hematopoiesis from multipotent stem cell -- Multi-potent hematopoietic stem cell -- Cluster of differentiation (CD) & other markers to identify LT-HSC and ST-HSC, and multipotent progenitor cells (MMPs) -- Kinetics of hematopoiesis -- Stroma cells.…”
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Stem and progenitor cells from peripheral blood

Table of Contents: “…Contents: Adult stem and progenitor cells have been found circulating in peripheral blood, allowing them to reach and integrate into all tissues -- Bone marrow is most likely the source of these cells, including endothelial progenitor cells (EPCs) -- Identification of circulating EPCs point to the possibility that vasculogenesis-mediated neovascularization, previously believed to be restricted to the embryonic stages, continues into adulthood.…”
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Hematopoietic stem cells and progenitor cells, their role in normal blood formation part 2 of 2 /

Table of Contents: “…Contents: Granulopoiesis -- Granulocyte-colony stimulating factor (G-CSF) -- Erythropoiesis -- Erythropoietin -- Thrombopoiesis -- Thrombopoietin -- Hematopoietic stem cell expansion: challenges and opportunities -- Telomerase (TERT+TR) expression & telomere length in long-term expansion cultures of umbilical cord blood CD 34+ cells -- Self-renewal probability of human hematopoietic stem cells is age dependent -- Hematopoietic stem cell expansion: challenges and opportunities -- The bone marrow sinusoidal vascular network -- Bone marrow stem cells evolve into various cells -- Perivascular homing and bone marrow retention of hematopoietic stem cells -- role of osteoblasts relative to SECs in stem cell homeostasis.…”
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Mouse embryonic stem cells

Table of Contents: “…Contents: Where Embryonic stem cells come from -- Testicular teratocarcinomas -- Differentiation of EC cells -- Interrelationships -- Isolation of embryonic stem cells -- Experimental mammalian genetics -- ES cells are a vector to the whole animal genome -- Mutation introduced via ES cells -- Consideration of the present situation.…”
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Clinical potential of stem cells

Table of Contents: “…Contents: Amphibians and organ repair -- Application of different cell types to the heart in animal models -- Stem cell repair is complex -- The mechanism of efficacy is unknown -- Intellectual property in autologous stem cells -- Autologous bone marrow cells can cause an increase in ejection fraction after myocardial infarction -- Definitive randomised, controlled, blinded trials are needed -- Gene therapy plus stem cell therapy is the future.…”
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Invasion, metastasis and stem cells

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DNA methylation and stem cells

Table of Contents: “…Contents: Stem cells -- Pluripotent stem cells are extremely valuable for disease modeling and regenerative biology -- DNA methylation -- Stable epigenetic modification.…”
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Translating retinal stem cells

Table of Contents: “…Contents: Retinitis pigmentosa -- Stem cell therapy -- Intracerebral retinal transplantation -- Transplantation of neural stem cells -- Retinal progenitor cell transplantation -- Characterization of hRPCs -- In vivo studies -- Allogeneic transplantation -- Clinical development.…”
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Stem cells and regenerative medicine

Table of Contents: “…Contents: Regenerative medicine aims to repair, regenerate or replace damaged tissues and organs -- Selection of appropriate cell sources -- Plasticity -- Differentiation of stem cells towards target phenotypes -- Medium supplementation -- Exposure to cell extracts -- Direct or indirect co-culture with other cells/tissues -- Genetic modification -- Scaffolds -- Bioprocessing systems -- Pre-clinical testing of novel stem cell-based therapies in animal models of disease -- Clinical trials -- Treatment of ischaemic heart failure with autologous bone marrow stem cells.…”
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Niche oncogenesis

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