Search Results - Genomics PLC~

Spindle movement and checkpoint control during mitosis in yeast

Get full text
Series

Biopunk Dystopias : Genetic Engineering, Society and Science Fiction / by Schmeink, Lars

Full text available:

Replication licensing

Table of Contents: “…Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? …”
Get full text
Series

The DNA damage response

Get full text
Series

Nucleosome assembly during DNA replication

Get full text
Series

Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
Get full text
Series

Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
Get full text
Series

Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
Get full text
Series

Nuclear control of respiratory chain expression by transcriptional activators and coactivators

Table of Contents: “…Contents: Contribution of nuclear and mitochondrial genomes to respiratory chain expression -- Genomic origin of respiratory chain subunits -- Cytochrome c as a model for respiratory gene expression -- DNA binding and transcriptional properties of nuclear respiratory factors (NRF-1 and NRF-2) -- Identification and characterization of NRF target genes -- Phenotypes associated with a targeted disruption of NRF-1 in mice -- NRF control of mitochondrial transcription factor expression -- The PGC-1 family -- PRC functional interactions with NRF-1 and CREB -- Cytochrome c promoter occupancy by PRC during the transition from quiescence to proliferative growth -- Potential role for PRC in integrating mitochondrial functions with cell growth.…”
Get full text
Series

Nuclear control of electron transport chain gene expression

Table of Contents: “…Contents: Introduction to the roles of mitochondria -- Subunits of the electron transport chain (ETC) in nuclear & mitochondrial genomes -- Transcription of the electron transport chain subunits -- Peroxisome proliferator-activated receptor gamma coactivators (PGC-1s) -- Nuclear respiratory factors (NRFs) -- Estrogen-related receptor (ESRRs) -- Mitochondrial transcription factors (Tfam and mtTFB) -- Yin-Yang (YY-1) -- Coordinated transcriptional regulation of ETC genes -- Summary/Closing Statements.…”
Get full text
Series

Bacterial extrachromosomal elements role in chemical detoxification and potential cancer therapy /

Table of Contents: “…Contents: Examples of degradative plasmids -- Xylene and toluene degradation by TOL plasmids -- The chloro-catechol orthocleavage pathway -- Catabolic pathways/genes in 2,4-D degradation -- Chemostatic evolution of 2,4,5-T degradative genes -- Unusual genomic structure of the 2,4,5-T genes -- Sequence characteristics of the clc element -- Evolution of s-triazine degradative plasmids -- Azurin interaction with different targets -- Structural features of azurin and immunoglobulins -- Secretion of azurin upon exposure to cancer cells -- Sequences in released extrachromosomal DNA -- Released CpG-rich DNA has anti-tumor activity.…”
Get full text
Series

Innate immunity in the intestine in health and disease

Table of Contents: “…Contents: Mucosal tissues of the human body -- Intestinal pathogens -- Mucosal immune system: distinctive features -- Gut-associated lymphoid tissue (GALT) -- Structure of the GALT: small and large intestine -- Mucus, a key protective barrier -- Antimicrobial proteins protect the epithelium -- Epithelial cell transcytosis of secretory IgA -- Uptake and transport of antigen by M cells -- Microbial sensing regulates intestinal homeostasis -- Sensing of microbes occurs through PRR -- MyD88 signals in IEC -- Intestinal macrophages are anti-inflammatory -- Intestinal DC 'conditioning' -- Inflammatory bowel disease (IBD) -- Genome-wide association studies -- The enigma of NOD2 and Crohn's disease -- NOD2 signaling in response to bacterial MDP -- NOD2 signaling regulates myeloid cell function -- Autophagy also regulates IEC and myeloid cells -- MyD88 activation drives intestinal inflammation -- Haematopoeitic MyD88 signals -- Immune dysregulation in chronic inflammation -- Innate lymphoid cells (ILC) drive innate IBD -- Leukocyte populations and intestinal homeostasis.…”
Get full text
Series

Culture Clash : Law and Science in America / by Goldberg, Steven, 1947-2010

Full text available:

Role of polycomb proteins in gene transcription, stem cell and human diseases

Get full text
Series