Search Results - "oxidative stress"

Oxidative stress in aging

Table of Contents: “…Contents: Characteristics of aging -- The decay of aging: cellular, tissue and organism level -- The longevity curves: maximum and average life span -- The theories of aging -- The free radical theory of aging -- Mitochondrial damage -- Markers of oxidative stress in aging -- Differences in oxidative stress in aging explain the differential longevity between genders -- Interventions: antioxidant vitamins, estradiol, regular exercise, caloric restriction, antioxidant enzymes.…”
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Oxidative stress and disease atherosclerosis /

Table of Contents: “…Contents: Oxidative stress, inflammation and fibrosis -- Redox-dependent expression of pro-fibrogenic cytokines -- Formation and evolution of fibrotic plaque: the primary role of inflammation -- LDL lipid oxidation products -- Lipid oxidation during the genesis of atherosclerotic lesion -- Enzymatic and non-enzymatic lipid oxidation products -- Pro-inflammatory and pro-fibrogenic effects of 4-hydroxy-2-alkenals -- Oxysterols of pathophysiological interest -- Oxysterols and atheroma formation -- Pro-inflammatory effects of cholesterol oxidation products.…”
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Oxidative stress in ALS

Table of Contents: “…Contents: Key facts -- The normal human motor system -- Motor neurone disease: clinical consequences -- Spared motor neurone groups -- Prognosis -- Features of motor neurones which may underlie selective vulnerability -- Complex and multifactorial disease -- Genetic factors -- SOD1 mutations -- Potential mechanisms of neuronal oxidative stress -- Sources of intracellular oxidative stress -- Mitochondrial free radical production -- ROS -- Evidence for the role of oxidative stress in ALS -- NSC34 cell model -- G93A mutant SOD1 -- Oxidative stress in human ALS -- Major pathogenetic factors -- Glutamate -- Excitotoxicity -- Mitochondrial dysfunction -- Potential mechanisms of action of antioxidant drugs -- Clinical trials.…”
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Oxidative stress in disease cardiac ischemia/reperfusion injury /

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Oxidative stress in COPD

Table of Contents: “…Contents: The involvement of oxidative stress in the pathogenic mechanisms of COPD -- Downregulation of antioxidant defenses -- Enhanced inflammation -- Apoptosis -- Protease/antiprotease imbalance -- Accelerated aging -- Immunemodulation -- Potential for targeted therapy.…”
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Metals, oxidative stress and neurodegeneration

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How trypanosomes cope with oxidative stress

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Protein oxidation and removal of oxidized proteins by proteolysis

Table of Contents: “…Contents: Oxidized proteins -- Intracellular proteases -- The 20S core proteasome -- Proteasomal particles -- The proteasome-ubiquitin system -- Protein oxidation and proteasome -- Degradation of oxidized proteins and protein function -- Protein surface hydrophobicity -- Unfolding of oxidized proteins -- Stability of the 20S proteasome towards oxidation -- Oxidative stress and protein turnover -- Oxidation-induced proteolysis -- Degradation of oxidized proteins in cells -- What happens if degradation fails? …”
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Exercise and free radical generation by contracting skeletal muscle

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Oxidative stress in development and neonatal diseases

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The chemistry and biochemistry of partially reduced oxygen species

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Lipid peroxidation from basic mechanisms to clinical relevance /

Table of Contents: “…Contents: Oxidant stress, lipid peroxidation and related terms -- Basic mechanisms of lipid peroxidation and relevance to human physiology and pathophysiology -- Methods to quantify oxidative stress and lipid peroxidation -- F2-Isoprostanes (F2-IsoPs) as indices of oxidant stress in vivo -- Role as markers in human physiology and pathophysiology -- Effects of interventions on IsoP formation -- Advantages and disadvantages of isoprostane quantification.…”
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Oxidative modification of brain proteins in Alzheimer's disease and models thereof role of amyloid beta-peptide (1-42) and insights from redox proteomics /

Table of Contents: “…Contents: Alzheimer's disease and mild cognitive impairment -- Oxidative stress markers in brain, including markers for protein oxidation and lipid peroxidation -- Amyloid beta-peptide-mediated oxidative stress and Alzheimer's disease -- Redox proteomics identification of oxidatively modified brain proteins, leading to new insights into protein dysfunction in and neurotoxicity of brain cells in Alzheimer's disease and mild cognitive impairment.…”
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Gluthatione antioxidant defense and regulation of its synthesis /

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Chemistry and biochemistry of molecular probes used in the detection of reactive oxygen and nitrogen species

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The SODs

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Antioxidants and immune response and infectious diseases

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Generation of reactive oxygen species by mitochondria

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Ubiquitin dependent degradation of proteins modified by oxidation, deamidation and glycation role in vision

Table of Contents: “…Contents: Description of cataract and AMD as the ultimate protein misfolding diseases -- Lens development: a model for aging research -- Photo-oxidative stress to the retina -- Etiology -- Environmental factors -- Pathophysiology -- Protein quality control -- Ubiquitin pathway selectivity for oxidatively modified, glutathiolated, deamindated and glycated substrates -- Clinical relevance.…”
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Introduction to free radicals and the oxygen paradox oxidative stress in biology, aging & disease /

Table of Contents: “…Contents: The oxygen paradox -- Oxygen origin -- Free radicals, oxidants and oxidative stress -- Sources of free radicals -- Environmental toxins -- Metabolic sources of free radicals: mitochondrial electron transport, phagocytes, peroxisomes, autooxidation -- Medical and dental sources of free radicals: x-rays, g-rays, drugs -- DNA damage and oxygen radical toxicity -- Antioxidant compounds and enzymes -- The dismutation of superoxide -- Mechanisms of antioxidant enzymes -- Antioxidant defense and repair systems -- Removal of oxidized DNA bases and DNA repair -- Lipolysis and the repair of oxidized lipids and lipid membranes -- Selective proteolytic degradation of oxidized proteins -- The LON protease -- Adaptation to oxidative stress -- Long-term effects of free radicals and oxidative stress: aging and disease.…”
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