Search Results - "metastasis"

Metastasis of Drosophila tumors

Table of Contents: “…Contents: Recessive lethal mutations of Drosophila cause brain tumors that are metastatic -- Despite their apparent similarities, tumors caused by different mutations have different metastatic properties -- The metastasis of tumors caused by lgl mutations is enhanced by secretion of MMP1 from the tumor cells themselves -- The metastasis of tumors caused by brat mutations is not enhanced by secretion of MMP1 from the tumor cells themselves, but is enhanced by MMP1 that host cells are induced to secrete.…”
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Genetics of tumor metastasis part 1 of 2 /

Table of Contents: “…Contents: Understanding carcinoma invasion and metastasis -- Epithelial-mesenchymal transition (EMT) -- Heterotypic signals in tumor growth and progression -- EMT-inducing transcription factors -- Transgenic model of breast cancer pathogenesis.…”
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Genetics of tumor metastasis part 2 of 2 /

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Invasion, metastasis and stem cells

Table of Contents: “…Contents: Vogelstein-Kinzler model of multi-step colon cancer pathogenesis -- Cell of origin determines tumor morphology and behaviour -- Hierarchical organization of normal epithelial tissues -- Similar hierarchical organization of cancer cells in a tumor -- The invasion-metastasis cascade -- Physical dissemination -- Adaptation to and proliferation in a foreign tissue -- Colonization -- Epithelial-mesenchymal transition (EMT) -- The microenvironment of the primary tumor -- Twist transcription factor -- Slug TF -- What is the nature of cells generated by an EMT? …”
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Macrophages a cellular toolbox used by tumors to promote progression and metastasis /

Table of Contents: “…Contents: Tumor microenvironment -- Macrophages promote tumor progression and metastasis -- Macrophage densities correlate with poor prognosis in many human cancers -- Macrophages regulate tumor cell migration and intravasation -- Macrophages regulate the angiogenic switch at the malignant transition -- Macrophage and tumor cells move using a paracrine mechanism involving CSF-1 and EGF -- Macrophages synthesize VEGF to regulate angiogenesis.…”
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How tumor-microenvironment interactions drive or inhibit metastasis

Table of Contents: “…Contents: Tumor Organismal Environment (TOE) and Tumor Microenvironment (TME) -- Principles of intra-TME interactions -- Tumor progression and regression -- Site-specific metastasis -- The pre-metastatic niche -- The metastatic cascade -- Epithelial to Mesenchymal Transition (EMT) -- Targeting tumor-TME interactions -- Immune checkpoint blocking enables TME-infiltrating T cells to kill tumor cells.…”
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Management of the N0 neck

Table of Contents: “…Contents: Patterns of spread of oral cancer -- Prognosis with metastatic neck disease -- Risk of occult metastasis -- Predictors of metastasis -- Tumour depth -- Perineural invasion -- Imaging of the node negative neck -- Sentinel lymph node biopsy -- Survival benefits of neck dissection.…”
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G proteins and GPCRs in cancer

Table of Contents: “…Contents: G proteins and GPCRs as oncogenes -- G proteins and GPCRs in tumorigenesis -- GPCR signalling -- GPCRs and metastasis -- GPCRs and tumor-induced angiogenesis -- GPCR targeting and immunotherapies.…”
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Solution proposed to a 2000 year old problem in oncology

Table of Contents: “…Contents: Primary cancer surgery -- Systemic inflammation -- Metastatic amplification -- Perioperative inflammation as triggering origin of metastasis development -- Hazards of relapse -- Computer simulations and clinical observations -- The linkage between wounding, immunology, inflammation and oncology -- Ketorolac and the uses of perioperative NSAIDs.…”
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The HGF receptor a targettable regulator of invasive growth /

Table of Contents: “…Contents: Trigger of invasive growth by specific signals -- Invasive growth receptors -- The "receptosome" -- Dynamics of invasive growth signalling -- The MET transcriptome -- HGF regulated genes -- Hypoxia regulates MET transcription -- The effector machinery of invasive growth: the coagulation cascade -- HGF antagonists impair tumor growth and metastasis: a gene therapy strategy.…”
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VEGF inhibitors for anti-angiogenic therapy

Table of Contents: “…Contents: Antagonist monoclonal antibodies to VEGFR-3 -- Mode of action of antagonist monoclonal antibodies -- Functional properties of antagonist antibodies to VEGFR-3 -- In vivo effects of anti-VEGFR-3 treatment on physiological lymphangiogenesis -- Inhibition of pathological vessel growth in the cornea -- Anti-angiogenic effect of antibodies to VEGFR-3 in tumors -- Inhibition of lymphatic metastasis with antagonist antibodies to VEGFR-3 -- Role of VEGFR-3 in normal and pathological immune response.…”
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VEGF inhibitors for anti-angiogenic therapy

Table of Contents: “…Contents: Antagonist monoclonal antibodies to VEGFR-3 -- Mode of action of antagonist monoclonal antibodies -- Functional properties of antagonist antibodies to VEGFR-3 -- In vivo effects of anti-VEGFR-3 treatment on physiological lymphangiogenesis -- Inhibition of pathological vessel growth in the cornea -- Anti-angiogenic effect of antibodies to VEGFR-3 in tumors -- Inhibition of lymphatic metastasis with antagonist antibodies to VEGFR-3 -- Role of VEGFR-3 in normal and pathological immune response.…”
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Clinical applications of molecular imaging imaging to guide cancer therapy /

Table of Contents: “…Contents: Anatomic vs. functional imaging -- Functional imaging modalities -- PET/CT -- Radiotracer imaging -- Existing cancer imaging paradigm -- A new paradigm for cancer imaging -- Imaging and targeted therapy -- Biomarker imaging -- ER expression and breast cancer endocrine therapy -- Hypoxia-specific treatment -- Biologic events in response to successful cancer therapy -- Thymidine incorporation pathways -- Bone metastasis response monitoring -- FDG PET vs. bone scan -- Neo-adjuvant therapy of breast cancer -- Molecular imaging is a tool for measuring in vivo biology -- Changes in breast cancer metabolism and blood flow predict pathologic response -- Clinical trial of novel molecular imaging probes for cancer -- ACRIN experimental imaging sciences committee.…”
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Changing paradigms in anticancer drug development inhibiting angiogenesis in colorectal cancer /

Table of Contents: “…Contents: Targeted therapy for cancer -- Angiogenesis is involved throughout tumour formation, growth and metastasis -- VEGF: molecular characteristics -- VEGF and other signals promote the angiogenic switch in tumours -- Tumour vasculature is abnormal -- VEGF produces immature tortuous vessels dependent on VEGF for survival -- Other features make VEGF an attractive target for anticancer therapy -- RhuMAb VEGF (bevacizumab/Avastin®) -- Significant reduction in microvasculature -- Anti-VEGF antibody improves drug delivery -- Avastin: an anti-VEGF agent for cancer therapy -- Use of Avastin with oxaliplatin-based therapy -- Addition of Avastin to oxaliplatin-based chemotherapy improved best confirmed response -- Study schema and organization.…”
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Tumor-associated macrophages

Table of Contents: “…Contents: The correlation between Tumor Associated Macrophage (TAM) infiltration and tumor progression in cancer patients -- Evidence for a protumoral function of TAMs in mouse tumor models -- Hallmark features of TAMs enable tumor progression -- Promotion of inflammation -- Chronic inflammatory diseases and cancer risk -- Promotion of matrix remodeling -- Promotion of tumor cell invasion -- Promotion of metastasis -- Promotion of angiogenesis -- TAM heterogeneity in tumors -- Identification and characterization of TAM subsets in mouse tumor models -- TIE2-expressing macrophages and inflammatory TAMs -- Origins of TAM subsets: Distinct hypothesis -- Tumor responses to anticancer therapies: Role of TAMs -- Reprogramming TAMs from a pro- to an anti-tumoral function -- Deciphering TAM heterogeneity in human cancer -- Complexity of leukocyte infiltrates in human cancer.…”
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