Search Results - "chromatin"

Dynamic chromatin ATP-dependent chromatin remodeling machines /

Table of Contents: “…Contents: ATP-dependent chromatin remodeling complexes -- ATP hydrolysis and nucleosome dynamics -- Mechanistic action -- Cellular function.…”
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Chromatin and transcription

Table of Contents: “…Contents: Chromatin remodeling for transcription -- The RNA polymerase II transcription machinery -- Mediator of transcriptional regulation -- Atomic structure of RNA polymerase II and of a transcribing complex -- Structural basis of ribonucleotide addition and transcript elongation -- Structure of a complete pre-initiation complex.…”
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Introduction to chromatin structure

Table of Contents: “…Contents: Chromatin and differential regulation of transcription -- Basic structure and properties of a nucleosome -- Current knowledge on higher order chromatin structures.…”
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Chromatin genes and disease

Table of Contents: “…Contents: Chromatin genes and disease -- Epigenetics: the phenotype reflects the pattern of gene expression -- The role of chromatin in epigenetic regulation -- Epigenetic factors and their role in gene expression -- Human diseases involving epigenetic factors.…”
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Genome-wide organization of chromatin and the transcription machinery

Table of Contents: “…Contents: Genomics of gene regulation -- Chromatin -- Canonical nucleosome organization around genes -- ChIP-exo mapping of sequence-specific transcription factors -- Genomic organization of transcription pre-initiation complexes.…”
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Chromatin architecture and alterations in the control of gene regulation

Table of Contents: “…Contents: The chromatin environment -- Hierarchical organization of chromatin fibers within interphase chromosomes -- Milestone experiments that linked chromatin architecture and gene expression -- Proteins and processes that influence both chromatin fiber architecture and gene expression -- Core histone N-terminal tail domains -- Core histone sequence variants -- Linker histones -- Heterochromatin proteins -- Histone post-translational modifications -- The structurally dynamic nature of the genome in vivo and its relation to gene expression.…”
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Skin epigenetics how chromatin regulators orchestrate skin functions /

Table of Contents: “…-- Genes encoding keratinocyte-specific proteins -- Molecular signature of epidermal layers -- Levels of epigenetic regulation -- DNA methylation and hydroxymethylation -- DNA methylation influence on the epidermis -- Post-translational histone/covalent modifications -- Histone acetylation/de-acetylation -- Polycomb-repressive complex -- Polycomb and Trithorax play antagonistic roles -- ATP-dependent chromatin remodeling -- Non-coding RNA-dependent mechanisms -- Nucleus: storage, replication of genetic material -- Topological gene interactomes -- Morphogenesis of the epidermis -- Epidermal differentiation complex -- EDC and Lor relocation to nuclear interior -- p63 and Brg1 ablation results in retention of EDC -- Genome organizer AT-rich binding Satb1 protein -- Transcription factor and epigenetic mechanisms -- Future directions of epigenetic research.…”
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The basal transcription machinery for RNA polymerase II

Table of Contents: “…Contents: The basal transcription machinery for RNA polymerase II -- DNA transcription -- Basal or general transcription factors -- Chromatin modifications -- RNA polymerase II -- TFIID -- Mediator.…”
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Eukaryotic gene regulation from chromatin to transcription to mRNA processing

“…Eukaryotic gene regulation : from chromatin to transcription to RNA messenger processing…”
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Polycomb epigenetic mechanisms Part 2 of 2, methylation of DNA /

Table of Contents: “…Contents: PRC2 has an untargeted global function -- Chromatin immunoprecipitation (ChIP-seq) profiles -- H3K27 methylation -- The CBP/p300 acetylase complex -- The TRR complex (MLL3,4 in mammals) -- The DNA accessibility model -- How do PcG complexes repress? …”
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Histone dynamics, heritability and variants

Table of Contents: “…Contents: DNA is organized into chromatin which promotes compaction and brings about additional information -- The histone code hypothesis -- Chromatin dynamics and heritability -- Factors involved in chromatin dynamics -- Nucleosomes disruption and assembly following DNA replication fork passage -- General steps in chromatin assembly -- Histone chaperones and their possible roles (CAF-1, HIRA, ...) -- Histone H3 variants and chromatin assembly coupled or not with DNA synthesis -- Specific histone deposition pathways for each variant? …”
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Series (Epigenetics : concepts, theories, paradigms and mechanisms)
Series (Eukaryotic gene regulation)
Series (Epigenetics, chromatin, transcription and cancer)

Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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The molecular mechanism of X chromosome inactivation

Table of Contents: “…Contents: X chromosome inactivation -- The X inactivation centre (Xic) -- Key role of the Xist locus -- Towards an understanding of Xist gene regulation in early mouse development -- Mechanisms regulating Xist RNA localisation within the inactive X chromosome territory -- Chromatin modification and gene silencing by Xist RNA.…”
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Enhancer malfunction in cancer

Table of Contents: “…Contents: MLL genes and their pathogenic translocations -- Yeast, mammalian and Drosophila systems for studying leukaemia pathogenesis -- Proteins and protein complexes that regulate chromatin modifications, transcription initiation, and transcription elongation -- What is the function of MLL? …”
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Polycomb epigenetic mechanisms part 1 of 2, role of PcG complexes /

Subjects: “…Chromatin. 94771…”
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Role of polycomb proteins in gene transcription, stem cell and human diseases

Table of Contents: “…Contents: Chromatin structure -- Histone modification and regulation of methylation -- Polycomb complexes (gene silencing, recruitement & displacement of proteins, protein levels in embryoid bodies, binding regulation) -- PcG genes and human cancers -- Variations of Polycomb Repressive Complexes and their associations with polycomb proteins -- CBX family of proteins -- The Polycomb-like gene family.…”
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Legacy of Drosophila genetics female germline stem cells /

Table of Contents: “…Contents: Lineage tracing -- Stem cell niches -- Germline stem cell niche in ovary -- Germline stem cell niche in testis – Dedifferentiation -- Stem cell signaling back to the niche -- Intestinal stem cells -- Stem cell chromatin.…”
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Cancer-specific epigenetic alterations as investigated from a pharmaceutical perspective

Table of Contents: “…Contents: Chromatin dysregulation in cancer -- Features of epigenetic information in cells -- Mutated chromatin regulatory factors as tumor drivers -- Therapeutic rationale for the use of epigenetic drugs in oncology -- First generation epigenetic drugs: DNMT and HDAC inhibitors -- Novel therapeutic discoveries in oncology -- Biomarkers for patient selection.…”
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Genomics 101 an introduction to sequencing /

Table of Contents: “…Contents: Sanger sequencing -- Fluorescent Sanger sequencing -- Whole genome sequencing -- Next generation sequencing -- Multiplexing -- Whole exome sequencing -- Transcriptome sequencing -- Chromatin immunoprecipitation sequencing.…”
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Epigenetic control by histone methylation

Table of Contents: “…Contents: The diversity of covalent histone tail modifications for imparting epigenetic information -- Observations of robust histone modifications at silent chromatin regions -- The representation of repressive histone marks as indications of epigenetic plasticity in different cells -- Analysis of the profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs. pro-neoplastic or metastatic conditions -- Elucidation of these histone modification patterns for novel advances in stem cell research, nuclear reprogramming and cancer.…”
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