Search Results - muleta~

The quest for multi-functional medicines path for progress, the Tamoxifen story. Lecture 1 /

Get full text

The quest for multi-functional medicines path for progress, the SERM story. Lecture 2 /

Get full text

Treatment effect estimates in multi-arm multi-stage (MAMS) clinical trials

Get full text
Series

Multi-site studies and field studies

Table of Contents: “…Contents: Conduct of multi-site and field studies in compliance with the OECD Principles of GLP -- Context, issues and complexities -- Responsibilities of test facility and test site personnel and sponsor -- Importance of communication -- Master schedule requirements for test sites -- Study plan requirements (with special reference to flexibility required for field studies) -- Performance of the study (with special reference to general facilities and to facilities for handling test and reference items and documentation required for field studies) -- Equipment, control and accountability of study materials for multi-site studies -- Reporting of study results -- Standard Operating Procedures -- Archives.…”
Get full text
Series

A concept for multi-marker approaches in clinical proteomics

Get full text
Series

Winner's curse, replication and meta-analysis

Table of Contents: “…Contents: Winner's curse: tendency to see a larger effect than usual upon discovery -- Examples from GWAS -- Methods for obtaining unbiased estimates -- Replication: confirming genetic associations in further studies -- Technical, direct and indirect replication -- Meta-analysis: combining multiple GWAS -- Forest plots, fixed and random effects, sources of heterogeneity in GWAS.…”
Get full text
Series

Meta-analysis in genome-wide association studies application to type 2 diabetes /

Get full text
Series

A survey of multi-locus methods for analysis of large SNP datasets

Table of Contents: “…Contents: Statistical challenges in genetic association studies -- Selection features of multi-locus methods and their strengths and weaknesses -- A multi-step approach to analyze large numbers of SNPs -- Application to a real case-control dataset.…”
Get full text
Series

Screening large-scale association study data exploiting multi-gene interactions with random forests /

Get full text
Series

Surrogate endpoints, part 1 from definition to meta-analytic framework /

Table of Contents: “…Contents: Discrete surrogates -- Prentice's definition -- Subsequent developments -- Single-trial validation framework -- Meta-analytic frameworks.…”
Get full text
Series

Quality and validity in animal research

Table of Contents: “…Contents: Quality and validity in animal model research are issues of scientific and ethical relevance -- High-quality research with high validity requires expertise in biological and clinical aspects in combination with knowledge in experimental design -- Contemporary research using systematic reviews and meta analysis have shown problems with the experimental design of many animal studies -- As a result of design shortcomings, results from many animal studies are not reliable -- This lecture addresses basic aspects of quality and validity of animal research using examples.…”
Get full text
Series

Management of MDR and XDR TB

Table of Contents: “…Contents: Management of multi drug resistance (MDR) and extensive drug resistance (XDR) TB -- Management of TB before era of drug treatment -- Surgery for TB -- Drug treatment was introduced from 1943-1963 -- Rifampicin (1963) -- Timeline: discovery of drugs for TB -- Emergence of totally drug resistant TB -- Epidemiology -- Outcomes of MDR-TB treatment -- Survival curve of HIV patients with XDR TB -- Current drug treatment -- Treatment outcome in several cohorts -- Death rates in several cohorts -- Current approach for treatment of MDR/XDR TB -- WHO's programmatic management of DR TB -- Treatment recommendations -- Group 1: oral first-line agents -- Group 2: fluoroquinolones -- Group 3: injectables -- Group 4: less-effective anti-TB drugs -- Group 5: less-effective or clinical data sparse drugs -- Future drug treatment -- New compounds -- Bedaquiline (TMC207) -- The nitroimidazoles -- Thioridazine -- NC-001 (PA-824, moxifloxacine, PZA) -- Dreams and realities for the future of TB treatment.…”
Get full text
Series

Imputing genotypes in genome-wide association studies

Table of Contents: “…Contents: Tag SNPs and multi-marker predictors -- The general problem of imputing genotypes for association studies -- The IMPUTE method -- Measuring accuracy of imputation -- Results of using imputation in a real study -- Using imputation for meta-analysis -- The importance of strand alignment when using imputation.…”
Get full text
Series

Controlling antibiotic resistance in the community

Table of Contents: “…Contents: Risk factors and control of multi-resisatnt pathogens -- Community-acquired MRSA -- Multi-drug resistant tuberculosis -- Extended spectrum beta-lactamase producing Gram negative bacteria -- Vancomycin resistant enterococci -- Antibiotic stewardship in primary care.…”
Get full text
Series

Phase II clinical trials traditional approaches /

Table of Contents: “…Contents: Frequentist methods -- Non-adaptive trial design -- Single stage single outcome design -- Randomized dose-ranging design -- Controlled titration design -- Adaptive trial designs -- Single outcome multi-stage designs -- Multiple outcomes multi-stage design.…”
Get full text
Series

Carcinogenesis and aging

Table of Contents: “…Contents: Historical journey into carcinogenesis and aging -- Age and susceptibility to carcinogens -- Cell senescence and cancer -- Multi-stage carcinogenesis and aging -- Geroprotectors and cancer.…”
Get full text
Series

An introduction to genetic association analysis

Table of Contents: “…Contents: What is genetic association -- Testing for genetic association -- Quantitative trait analysis -- Covariates -- Family-based tests -- Multi-SNP models.…”
Get full text
Series

Genetic association studies the candidate gene approach /

Table of Contents: “…Contents: Background of genetic studies -- Structure of a gene -- Simple association -- Linkage disequilibrium and haplotypes -- Multi-marker association -- Family-based association -- Practicalities of programs and power.…”
Get full text
Series

The End TB Strategy towards TB elimination, part 1/

Table of Contents: “…Contents: Tuberculosis -- WHO -- The End TB Strategy -- Tuberculosis elimination -- Multi-drug resistant TB -- TB and HIV -- Sustainable Development Goals -- UN Millennium Development Goals.…”
Get full text
Series

Major transitions in the history of life

Table of Contents: “…Contents: The origin of life -- Major transitions and size increase -- Formation of cells -- Molecules in the cellular environment -- Complex cells -- Conflict mediation -- Multi level selection -- Multicellularity -- Origin of societies.…”
Get full text
Series