Search Results - muf~

Billion-dollar lessons what you can learn from business failures / by Mui, Chunka

Biased signaling at mu opioid receptor splice variants

Table of Contents: “…Contents: Extensive alternative pre-mRNA splicing of the mu opioid receptor gene (OPRM1) -- Distinct intracellular C-terminal tails in different full-length 7TM C-terminal variants -- Distinct in vivo functions of several C-terminal tails -- In vivo truncation of C-terminal tails encoded by E7 affects morphine tolerance and reward -- In vivo truncation of C-terminal tails encoded by E4 affects morphine tolerance and dependence.…”
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Safer opioid analgesics targeting truncated Mu opioid receptor splice variants /

Table of Contents: “…Contents: Mu opioid receptor -- Opioids -- Morphine -- Alternative splicing of OPRM1 -- Analgesia -- 3'-iodobenzoyl-6beta-naltrexamide (IBNtxA) -- Lentivirus analgesia rescue.…”
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EGF receptor family targets for cancer therapeutics /

Table of Contents: “…Contents: The association of the Epidermal Growth Factor Receptor (EGFR) with the tumorigenic state -- The four related members of the EGFR family (EGFR, erbB2, erbB3 and erbB4) -- Signaling of the activated receptors as either homo- or heteromeric oligomers -- Activation of the EGFR by excess ligand stimulation, receptor over-expression and/or mutation in many carcinomas -- Utility of antibodies and receptor kinase inhibitors which interfere with signaling from the EGFR family as agents in cancer therapy -- The three-dimensional structures for the extracellular domains of EGFR, erbB2, erbB3 and erbB4 and the discovery that EGFR, erbB3 and erbB4 undergo major conformational transitions when interacting with their ligands -- Development of antibodies (mab806) which reduce tumor formation from cells expressing either truncated D2-7 EGFR or over-expressed EGFR by binding to the receptor in a region normally masked by the dimerization of the EGFR extracellular domain -- Use of EGFR antagonists or inhibitors to increase tumor killing by cytotoxic anti-cancer drugs and/or radiation -- Improvement of tumor killing by combining EGFR antagonists and EGFR kinase inhibitors.…”
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EGF receptor family targets for improving cancer therapy /

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Gene silencing in budding yeast

Table of Contents: “…Contents: Gene silencing: an epigenetic phenomenon -- Chromatin remodeling: heterochromatin and euchromatin -- Silent chromatin in budding yeast: mating-type loci -- Silent information regulation: telomeric genes and Sir proteins.…”
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EGF-TM7 receptors

Table of Contents: “…Contents: F4/80 is a marker for mouse macrophages -- The EGF-TM7 receptors EMR1 (F4/80), EMR2, EMR3, EMR4 and CD97 belong to the adhesion class of GPCRs -- Evolution, expression and structure of EGF-TM7 receptors -- EGF-TM7 receptors bind cell- and matrix-associated ligands -- Role of EGF-TM7 receptors in immunity.…”
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Avoidable deaths and harm due to medical negligence

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The microbiota in the development of colitis due to Clostridium difficile infection

Table of Contents: “…Contents: C. difficile and the antibiotic-associated colitis -- Changes in the microbiota due to antibiotics predisposed to C. difficile infection -- Use of culture-independent techniques to study the gut microbiota -- Antibiotics can have reproducible effects on the gut microbiota -- Animal models and human studies provide insight into the role of the gut microbiota in mediating colonization resistance against C. difficile infection.…”
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Handling multiplicity due to multiple primary or composite endpoints in clinical trials

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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Soreness and ulcers 4: due to gastrointestinal disease /

“…Soreness and ulcers. 4: due to gastrointestinal disease…”
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Structural basis for Fibroblast Growth Factor (FGF) receptor activation implications in development and disease /

Table of Contents: “…Contents: FGF family of ligands, and FGF receptor (FGFR) subfamily of receptor tyrosine kinase superfamily -- The roles of FGF signaling in mammalian biology and diseases -- FGFR receptor alternative splicing and its essential role in epithelial-mesenchymal signaling loop, and organogenesis -- Structural mechanism by which FGF and heparan sulfate induce FGFR dimerization and activation on the cell surface -- A working model for FGFR autoinhibition -- Structural mechanisms by which FGF-FGFR binding specificity is achieved -- Structural basis for how alternative splicing regulates ligand-binding specificity of FGFRs -- Structural basis by which ligand-dependent pathogenic mutations in FGFR lead to receptor gain-of-function in human skeletal syndromes -- Structural basis by which alternative splicing regulates patterning ability of FGF8 in the brain.…”
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Soreness and ulcers 3, due to vesiculobullous disease, Part 1 of 2 /

“…Soreness and ulcers. 3: due to vesiculobullous disease. Part 1…”
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Soreness and ulcers 3: due to vesiculobullous disease. Part 2 of 2 /

“…Soreness and ulcers. 3. due to vesiculobullous disease. Part 2…”
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The two Escobars /

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Soreness and ulcers 1, Recurrent ulcers due to aphthae and aphthous-like ulcers /

“…Soreness and ulcers. 1, Recurrent ulcers due to aphthae and aphthous-like ulcers…”
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The discovery of ATL field expansion in 40 yrs

Table of Contents: “…Contents: Life cycle of retroviruses -- Diseases derived from retroviruses -- Adult T-cell leukemia and HTLV-1 retrovirus -- ADF/TRX upregulation in HTLV-I T-cell and EBV B-cell transformation -- Regulation of thioredoxin gene expression -- TRX TG and KO mice -- The thioredoxin system -- MIF/GIF -- Inflammatory response -- TBP2: tumor suppressor for HTLV-I leukemia -- Clinical trials for inflammatory diseases.…”
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Vaccine adjuvants part 1 of 2 /

Table of Contents: “…Contents: Overview of vaccine adjuvants -- First generation particles -- Alum adjuvants -- MF59 adjuvant -- Polylactide co-glycolide particles.…”
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Asthma an epidemic caused by epigenetics? /

Table of Contents: “…Contents: Genetic and biological determinants of diseases influenced by the environment -- Epigenetics -- Epigenetic mechanisms can be influenced by environmental exposures and aging -- Histone modifications and innate immunity -- Asthma is a major public health problem -- Epigenetics and airway immunology -- DNA methylation changes and asthma -- Runx3 and airway disease -- In utero folate supplementation and asthma -- Sib pair asthma study -- preliminary analysis -- Global methylation patterns: asthmatics vs. nonasthmatics -- Hypomethylation of GATA3 or MUC5B is associated with asthma in concordant sib pairs -- Hypermethylation of NOS2 is associated with concordant asthma -- Asthma: an epidemic caused by epigenetics?…”
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