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Kilio cha haki

Kilio cha haki : Uchambuzi

The Eph receptor family

Table of Contents: “…Contents: Members of the Eph receptor and ephrin ligand families and specificity of binding interactions -- Domain structure of Eph receptors and ephrins -- Eph receptor-ephrin interactions -- Dimerization, tetramerization and further clustering in Eph-ephrin signaling -- Tyrosine phosphorylation in Eph-ephrin activation -- Modes of signal termination -- Eph-ephrin signaling pathways affecting the actin cytoskeleton and cell adhesion: Cell repulsion versus adhesion/attraction, pathways that are activated downstream of Eph receptors -- Main Eph effects on cell behavior: shaping and positioning cellular processes and cell migration -- Eph receptors in topographic mapping in the visual system -- Eph receptors in the organization of axonal projections -- Eph receptors in angiogenesis and lymphangiogenesis -- Eph receptors in stem cell proliferation and differentiation -- Eph receptors in cancer -- Eph receptors as drug targets.…”
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Genetic testing for CHD risk fact or fiction? /

Table of Contents: “…Contents: Family history is a strong independent risk factor for early CHD -- Criteria for useful CHD-Risk DNA tests -- Analytical validity -- Clinical validity -- Risk estimates for genetic effects -- Clinical utility -- Risk score methods -- CRP: origin, clearance and function -- Is it likely that genotype will predict risk over and above trait measure? …”
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Macrophages in AMD

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Introduction to the immune system

Table of Contents: “…Contents: Innate immunity -- Adaptive immunity -- Lymphocytes -- Antibodies -- Immunoglobulin classes -- Antigen presentation and antigen binding -- MHC class I and II.…”
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Familial hyperchlolesterolaemia a monogenic cause of early CHD /

Table of Contents: “…Contents: Clinical diagnostic criteria -- Prevalence in UK -- Effects of statins on cholesterol and CHD risk lowering -- The 3 genes where mutations cause FH (LDLR, APOB, PCSK9) -- Clinical Genetics Diagnostic service for FH and examples in families -- Cascade testing for FH patients using LDL cholesterol levels -- The Overlap problem -- The Simon Broome FH register project and the high risk of early CHD in those with an LDLR and PCSK9 mutation -- The LDLR mutation database -- Ethical issues about genetic testing for FH -- Clinical questions in the management of FH -- FH testing and insurance.…”
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Mitochondrial and lysosomal dysfunction in the pathogenesis of Parkinson's disease

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Research & development of new pharmaceuticals for treatment of endometriosis

Table of Contents: “…Contents: Limitation of current treatment of endometriosis -- Pathophysiology of endometriosis -- Anti-proliferation of endometriosis by new progesterone -- Anti-immune escape of endometriosis by immunomodulator targeting MDSCs -- Anti-adhesion of endometriosis by herbal medicines and active components -- Anti-angiogenesis of endometriosis by green tea and derivatives -- Pharmacokinetics of biologics.…”
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Tissue damage control confers host tolerance to infection

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GnRH agonist use for fertility preservation despite gonadotoxic chemotherapy

Table of Contents: “…. -- Methods of fertility preservation -- The rationale of ovarian suppression by GnRHa for fertility preservation -- The efficacy of GnRHa -- The safety of GnRHa -- The GnRHa debate (why?) …”
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Mycetoma

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Photoreceptor protection significance of docosanoids and elovanoids. Part 1 of 2, docosahexaenoic acid (DHA) /

Table of Contents: “…Contents: Biosynthesis of docosanoids -- Essential fatty acids -- Neuroprotective bioactivity during oxidative stress -- AdipoR1 as a regulatory switch of the DHA.…”
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Photoreceptor protection significance of docosanoids and elovanoids. Part 2 of 2, bioactive derivatives of DHA /

“…Bioactive derivatives of DHA…”
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Epigenetics as a paradigm for cancer treatment chemically targeting the histone lysine methyltransferase EZH2 /

Table of Contents: “…Contents: Cancer as an unmet medical need -- Epigenetics as a paradigm for treating cancer -- Histone lysine methyltransferase EZH2 as a target class example -- Development of EZH2 inhibitors.…”
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The MHC and MHC molecules part 1 of 2 /

Table of Contents: “…Contents: The definition and the central role of MHC molecules -- Classical class I and class II MHC molecules -- Non-classical MHC molecules -- MHC genes and organization in humans and mice -- Differences between class I and class II molecules -- The function of different MHC molecules in human and mice.…”
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The MHC and MHC molecules part 2 of 2 /

Table of Contents: “…Contents: Genetics, nomenclature, polymorphism, and function of MHC molecules -- Mouse genetics is largely based on inbred strains -- Transplantation and T cell selection in the thymus -- Autoimmunity, allergy, and immunopathology -- MHC and mate choice and reproduction -- MHC-determined pathogen and infectious disease resistance.…”
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Colorectal cancer and the rare variant hypothesis

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Genetic and environmental triggers of autoimmune thyroid diseases

Table of Contents: “…Contents: Autoimmune thyroid diseases (AITD) -- Identification of AITD susceptibility genes -- Iodine and AITD -- MHC class II genes, CTLA-4, and CD40 -- Sequencing efforts -- Environmental and genetic triggering factors of AITD -- Genetic studies and etiology of AITD -- Development of AITD.…”
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Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization

Table of Contents: “…Contents: Calcium-entry -- Elements of the compartment: adenylyl cyclases, lipid rafts, PP2A, NHE1, calmodulin and PDE -- cAMP kinetics within the compartment in single cells: role of PDE4, PKA and AKAPs -- cAMP oscillations.…”
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