Search Results - HubSpot~

Possible roles of mitochondrial biogenesis in aging

Table of Contents: “…Contents: Oxidative phosphorylation -- The mitochondrial DNA -- Aging as the accumulation of damage -- Types of aging damage -- Types of damaged cells -- Survival of cells lacking oxidative phosphorylation -- The plasma membrane redox system -- Reductive hotspot hypothesis -- "Survival of the slowest" hypothesis -- Allotopic expression -- Hydrophobicity prevents allotopic expression of mitochondrially-encoded proteins -- Ways to make these proteins allotopically expressible.…”
Get full text
Series

Macroecology

Table of Contents: “…-- Definitions, emergence as a field -- Macroecological patterns -- Species-area relationships -- Body size-diversity -- Body size-abundance -- Abundance-range size -- Bergmann's rule -- Hotspots of species richness -- Latitudinal diversity gradient -- Biases -- Modern macroecology -- Mechanistic and predictive models.…”
Get full text
Series

The HapMap project

Table of Contents: “…Contents: The problem in pedigree analysis -- A possible solution for the resolution limitations in pedigree analysis -- Theory of two loci -- Linkage equilibrium and disequilibrium -- Recombination events between SNPs -- Genealogical interpretation -- Statistical significance of LD -- The effect of random drift on linkage disequilibrium -- Variability of LD among different populations -- Heterogeneity of LD across the genome -- Hotspots of recombination -- Tag SNPs -- The HapMap website -- Design of GWAS -- Welcome Trust Case Control Consortium -- Etiology.…”
Get full text
Series

The future of CNVs sequence based resolution and links to human disease, part 1 of 2 /

Table of Contents: “…Contents: Human genetic variation -- "Normal" structural variation -- Copy number polymorphism and disease -- Duplicated sequences: copy number variant (CNV) hotspots -- Structural variation and enriched gene functions -- Array comparative genomic hybridization -- Insufficiency of CNV detection -- Sequence-based resolution of structural variation -- Genome-wide detection of structural variation -- Validated sites of structural variation -- Frequency and length distribution -- APOBEC3B -- Breakpoint heterogeneity -- Detection of novel insertion sequences.…”
Get full text
Series (Copy number variation)
Series (Biomarkers)

RAS pathway and disease neurofibromatosis and beyond /

Table of Contents: “…Contents: Neurofibromatosis type 1 (NF1) -- NIH diagnostic criteria (Seven criteria for NF1) -- NF1 and the RAS pathway -- NF1 tumour biology -- Neurofibromin deficiency -- Two types of neurofibromas -- Plexiform neurofibroma in the neck and mouth -- Mechanisms of disease -- Mouse models of neurofibroma formation -- Imatinib mesylate treatment -- Clinical aspects of glomus tumours of fingertips -- Gastrointestinal stromal tumours -- MPNST in NF1 -- FDG-PET as a diagnostic tool -- Hotspots for recombination & NF1 microdeletion -- SUZ12-loss -- Cafe-au-lait (CAL) macules -- Skeletal defects in NF1 -- Learning disabilities in NF1 -- Simvastatin treatment for cognitive deficits -- Mosaicism for NF1 mutation -- Diagnostic problems -- SPRED1 mutations & molecular mechanism of Legius syndrome -- The RAS pathway proteins & genetic syndromes (RASopathies).…”
Get full text
Series