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Spindle movement and checkpoint control during mitosis in yeast

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Spindle movement and checkpoint control during mitosis in yeast

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Spindle movement and checkpoint control during mitosis in yeast

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Replication licensing

Table of Contents: “…Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? …”
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The DNA damage response

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Nucleosome assembly during DNA replication

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Replication licensing

Table of Contents: “…Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? …”
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Replication licensing

Table of Contents: “…Contents: Problems in ensuring complete genome replication -- Experiments revealing the existence of a replication licence -- The licensing reaction -- ORC, Cdc6, Cdt1 and Mcm2-7 -- Cell cycle regulation of licensing -- Pre-RC substrates in yeast -- Regulation of licensing in animal cells by Cdt1 degradation and geminin inhibition -- Is there a licensing checkpoint? …”
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The DNA damage response

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The DNA damage response

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Nucleosome assembly during DNA replication

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Nucleosome assembly during DNA replication

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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Systems biology of the cell cycle

Table of Contents: “…Contents: Control of cell cycle progression in eukaryotes by a network of universal protein interactions -- This dynamic system oscillates once per cell cycle -- Oscillation ceases when genomic integrity is in jeopardy -- The negative feedback loop by which Cdk1/CycB promotes CycB degradation via activation of APC/C -- Bistable ("toggle") switches are also important design principles of eukaryotic cell cycle control network -- The cell cycle.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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Immune-mediated liver disease

Table of Contents: “…IBD+PSC -- Causes of death in PSC patients -- Treatment for PSC with Ursodeoxycholic acid -- Why medical therapy fails in PSC -- Recurrent Autoimmune after liver transplant -- Primary Biliary Cirrhosis (PBC) -- PBC- physical presentation -- Typical presentation of PBC in 2009 -- Liver transplant in PBC compared to PSC -- Longterm survival in early PBC -- Survival in PBC +/- Biochemical response to Ursodeoxycholic acid -- Survival according to portal/hepatic venous gradient score -- PBC: natural history -- Treatment response and histological change in PBC -- Complications of PBC -- PBC: the drive and the trigger -- PBC cases in first degree relatives -- PBC: genome wide analysis -- The genetic web of autoimmunity.…”
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