Search Results - Geneva~

The generation of diversity in antibody genes

Table of Contents: “…Contents: Historical perspective on antibodies and immunity -- Nature and structure of antibodies and immunoglobulin fold -- Theories of antibody formation -- Clonal selection theory -- Mechanisms contributing to antibody diversity -- Organization of immunoglobulin loci -- Immunoglobulin gene rearrangement and generation of the primary repertoire -- RSS elements -- RAG genes and mechanism of V-D-J joining -- Membrane immunoglobulin and the B-cell antigen receptor -- Secondary antibody repertoire and diversification of rearranged immunoglobulin genes -- Affinity maturation -- Somatic hypermutation, gene conversion and class-switch recombination -- DNA deamination as a central trigger for these three diversification processes -- Detailed pathways of antibody gene diversification -- AID and the evolution of DNA deamination.…”
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Next generation sequencing in genetic diagnostics

Table of Contents: “…Contents: Sanger sequencing -- Next generation sequencing (NGS) technologies -- Target enrichment -- Analysis of NGS data -- Neurogenetics -- Applications of NGS technology in genetics diagnostics (Dementia diagnostic panel, Parkinson's disease NGS diagnostic panel).…”
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Genetic variation in gene regulation

Table of Contents: “…Contents: Expression Quantitative Trait Loci: linking genetic variation to changes in gene regulation -- How do SNPs impact gene regulation -- HapMap cell lines as a model system for studying expression variation -- eQTL analysis -- dsQTL -- Histone marks -- Protein-specific QTLs.…”
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Gene-drives and active genetics introduction to gene-drives and their implications for health and society /

Table of Contents: “…Contents: Gene drives: overview -- CRISPR/Cas9 technology -- CRISPR/Cas9 DNA break repair -- Gene-drive elements spread rapidly in a population -- Active genetics: a new field -- Gene-drive systems -- Active genetics and drive effectors -- DNA repair mechanisms -- Mathematical modeling -- Social and ethical considerations.…”
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Manufacturing viral gene therapy vectors general approaches and challenges /

Table of Contents: “…Contents: Manufacturing of Viral Gene Therapy Vectors -- Different types of vector production systems -- Concepts for the design of viral vector production cells -- Specific viral vector production systems for adenovirus, adeno-associated virus, gamma-retrovirus, and lentivirus -- Downstream processing -- Regulatory considerations.…”
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The orphan generation : Including these are our children /

God's generals : by Liardon, Robert

General management

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Evolutionary genetics the detection of natural selection using molecular data /

Table of Contents: “…Contents: Mutation and variation in populations -- The fate of mutations under random genetic drift and natural selection -- Measures of variation -- Detecting signatures of natural selection in genomic data.…”
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Drosophila genetics the first 25 years /

Table of Contents: “…Contents: Sex linked inheritance, linkage and linear chromosome maps -- Non-disjunction -- Genic balance theory of sex determination -- Chromosome aberrations -- Mutational studies of the gene -- X-ray induction of gene and chromosome mutations -- Cytological dissection of the X chromosome -- Mitotic cytology -- Polytene cytology.…”
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The genetics of pain

Table of Contents: “…Contents: Variability in pain sensitivity and analgesia -- Heritability of pain -- Genetic and environmental contributions to pain -- Pain genes -- Monogenic pain disorders -- Association studies -- Inbred mouse strains and strain differences -- Genetic correlations among pain phenotypes -- Quantitative trait loci (QTLs) -- Melanocortin-1 receptors and pain -- Formalin test QTLs -- Haplotype mapping -- Atp1b3 and formalin pain.…”
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Genetic toxicology

Table of Contents: “…Contents: Mutagenicity testing -- Clastogenicity testing -- Additional assays -- Regulatory genetic toxicology -- Current regulations -- In vitro mutagenicity and clastogenicity -- In silico -- Integration of results and data interpretation -- Genotoxic impurity testing.…”
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Genetics in forensics

Subjects: “…Forensic genetics. 114054…”
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Population genetics

Table of Contents: “…Contents: Studying human evolution using population genetics -- The history of population genetics -- Demographic models -- DNA datasets -- Example genealogies -- Calculating summary statistics (number of polymorphisms; average pairwise difference; Tajima's D) -- Inference -- Statistical significance -- Current work in population genetics -- Population genetics studies in Africa.…”
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Genetics of COPD

Table of Contents: “…Contents: COPD-important world-wide cause of morbidity and mortality -- Clear evidence of a genetic contribution to disease risk -- Genome wide association studies have identified genes predicting lung function -- Role of these genes in COPD pathophysiology.…”
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Genetics of epilepsy

Table of Contents: “…Contents: Epilepsy and genetics -- Significant contribution of genetics to many epilepsies -- Many types of variation, and methods to detect them -- Importance of correct interpretation -- Will likely revolutionise understanding.…”
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The genetics of glioblastoma

Table of Contents: “…Contents: Classifications of glioblastoma -- Isocitrate dehydrogenase 1 mutation as the fundamental mutation in malignant glioma -- The genetic mechanism of telomere maintenance in gliomas -- Molecular subclassifcation of gliomas.…”
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Genetic testing prediction vs. risk /

Table of Contents: “…Contents: Genetic principles -- "Traditional" Sanger sequencing and how it led to development of high throughput sequencing -- The principle underlying high throughput sequencing -- Some applications of high throughput sequencing including obesity -- The difference between risk vs. prediction in genetics.…”
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The genetics of stuttering

Table of Contents: “…Contents: The genetics of stuttering -- Genetics -- Neuroscience -- Speech and language pathology -- Twin and adoption studies -- Medical genetics -- Mice as a model for stuttering.…”
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Genetic counseling preconception, prenatal, perinatal /

Table of Contents: “…Contents: Genetic counseling -- Prenatal genetic diagnosis -- Congenital malformations -- Ethics -- Confidentiality -- Law.…”
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