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The neurobiology of decision making a window on cognition /

Table of Contents: “…Contents: Neurobiology -- Decision making -- Neural mechanisms of decision making -- Perceptual decisions -- Representation of evidence in visual cortex (area MT/V5) -- Direction selective neurons -- Representation of accumulated evidence in parietal cortex -- Lateral intraparietal area (LIP) -- Bounded evidence accumulation -- Diffusion models of decision making -- Confidence and "degree of belief" -- Post-decision wagering -- Probabilistic reasoning -- A neural mechanism for reasoning -- log likelihood ratio -- Decision making as a window on cognitive function in general -- Intentional framework for information processing.…”
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Role of neutrophils in acute lung injury and repair

Table of Contents: “…Contents: Clinical problem of acute lung injury and ARDS -- physiological role of neutrophils in host defense and innate immunity -- pathological role of neutrophils in inflammatory tissue injury in general and in acute lung injury -- mechanisms of damage to the lung epithelium by neutrophils -- paradoxical role of neutrophils in initiating repair processes.…”
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Canonization, Morgan algorithm, equivalence classes

Table of Contents: “…-- Basic definitions: permutation, symmetric group, automorphism -- Applications and implementations of canonizers -- Morgan Algorithm -- General strategies: initial classification, iterative refinement, labeling by backtracking, pruning the backtrack tree, profiting from symmetry -- Symmetrically equivalent atoms -- Outlook: equivalence classes of molecular graphs.…”
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Epilepsy in children

Table of Contents: “…Contents: Incidence of Seizures -- Classification of Seizures -- Prevalence of Generalized and Partial Seizures -- Epileptic Syndromes -- Benign Familial Neonatal Seizures -- Generalized Epilepsy Febrile Seizures + -- Idiopathic Focal Epilepsies of Infancy and Childhood -- Benign Rolandic Epilepsy -- Idiopathic Generalized Seizures -- Epileptic Encephalopathies -- Infantile Spasms -- Lennox-Gastaut Syndrome -- Epilepsy in Association with Other Neurological Conditions -- Angelman Syndrome -- Tuberous Sclerosis -- Rett Syndrome -- Fragile X Syndrome -- Lissencephaly.…”
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Status epilepticus

Table of Contents: “…Contents: Generalized status epilepticus -- Evolution of the definition of status epilepticus -- Epidemiological studies of status epilepticus -- Basic mechanisms of status epilepticus -- Treatment approaches for status epilepticus in the hospital and out-of-hospital settings.…”
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Disorders of gastric function gastroparesis and functional dyspepsia /

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Pancreatic cancer

Table of Contents: “…Contents: General epidemiologic data for pancreatic cancer -- Review risk factors for pancreatic cancer -- Clinical presentation and diagnostic modalities for pancreatic cancer -- Current status for early detection, diagnosis and staging of pancreatic cancer -- Treatment of pancreatic cancer.…”
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Protein kinase structure, function and regulation

Table of Contents: “…Contents: Overview of protein kinase structure and function using PKA as a prototype for this enzyme superfamily -- What we have learned from the overall structural kinome -- Comparison of many protein kinases -- Eukaryotic protein kinase regulation -- Elucidation of general rules of architecture -- Illustration of how PKA is regulated by cAMP and how it is localized to specific macromolecular complexes through scaffold proteins.…”
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Immunologic mechanisms in systemic lupus erythematosus

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DNA methylation, inflammation and cancer

Table of Contents: “…Contents: DNA methylation in cancer in general -- Lung cancer -- Intestinal cancer -- Inflammation -- Method for genome-wide DNA methylation profiling -- Association of the Polycomb complex with DNA methylation in inflammation and cancer.…”
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Copy number variation in neuropsychiatric disorders

Table of Contents: “…Contents: Copy Number Variation (CNV) in the human genome -- General characteristics -- Detection methodologies -- Copy number variation and human disease -- Cataloguing and assessing the biological impact of a copy number variant -- The genetic basis of Autism spectrum disorder (ASD) and the role of CNVs in ASD etiology -- Variable neuropsychiatric phenotypes associated with copy number variation -- Diagnostic and interpretation challenges.…”
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Copy number variation

Table of Contents: “…Contents: Copy number variation (CNV): a basic introduction -- Theory -- Concepts -- Applications -- CNV studies in the general population -- CNV in disease studies.…”
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Introduction to toxicogenomics and example case studies

Table of Contents: “…Contents: What is toxicogenomics and what is it not? -- General considerations -- Compound discrimination -- Pathway modeling -- Modulation of the notch pathway -- Altered transcripts -- Understand compound mechanism of action -- Case study: hepatotoxicity -- For the future: translation.…”
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Phagocytosis in the fruit fly, Drosophila melanogaster

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Small molecule inhibitors of receptor tyrosine kinases

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Transcriptional activation

Table of Contents: “…Contents: Transcription by RNA polymerase II -- Mediator complex -- Coactivator proteins -- Communication between DNA-binding proteins and general transcription machinery.…”
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Structure and mechanism of the tyrosine kinase domain of the insulin receptor

Table of Contents: “…Contents: Introduction to receptor tyrosine kinases (RTKs) -- general mechanisms of protein recruitment to RTKs -- Structure of the insulin receptor tyrosine kinase domain (IRK) -- Autoinhibitory mechanisms in RTKs -- Structure of the Src homology-2 (SH2) domain of APS -- Structure of the APS SH2 domain bound to IRK -- Inhibition of IRK activity by Grb14 -- Structure of the Grb14 BPS region bound to IRK -- Structure of the Grb14 SH2 domain -- Model of the interaction between Grb14 and the insulin receptor.…”
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Mechanisms of transcription the eukaryotic pre-initiation complex /

Table of Contents: “…Contents: Overview of RNA polymerase II transcription -- Core promoter elements -- Proximal promoters -- Enhancers and silencers -- General transcription factors -- Activators and repressors -- Coactivator complexes -- RNA polymerase II structure and function -- Mechanisms of transcription initiation -- Steroid hormone receptors -- Coactivator complexes, including mediator and TFIID -- Chromatin remodellers including SWI/SNF -- Covalent histone modifiers, including histone acetyltransferases, methyltransferases and deacetylases.…”
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Protein import into chloroplasts

Table of Contents: “…Contents: The endosymbiotic origin of chloroplasts -- Protein import as a result of genome rearrangements -- Different targeting pathways -- The general import pathway -- Properties of the targeting process -- Cytosolic components -- Components of the Toc and Tic translocon -- Stromal components -- Phylogenetic origin of the import apparatus.…”
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Genetic susceptibility in granulomatous disorders chronic beryllium disease and sarcoidosis /

Table of Contents: “…Contents: Role of genetics x exposure in environmental lung disease -- Granulomatous disorders and immunologic mechanistic basis: berylliosis and sarcoidosis -- Immunogenetics that may apply generally to granulomatous disorders -- Berylliosis: genetic epidemiology studies, functional genomics and gene x environment interaction studies -- Role of exposure vs. genetic basis -- Sarcoidosis: genetic epidemiology studies, attempts at functional genomics and directions for research to use clinical phenotype and genotype information to improve and help direct the search for an unknown causative agent -- Possible implications for other (non-granulomatous) environmental lung disorders.…”
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