Search Results - Cancer*

Epigenetic information in gene expression and cancer

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RNA interference and cancer a revolution? /

Table of Contents: “…Contents: Cancer overview -- RNA interference to understand cancer -- Natural short RNAs in cancer -- RNA interference to fight cancer.…”
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Imatinib as a paradigm of targeted cancer therapies

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Series (Signal transduction via protein tyrosine kinase receptors)
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Molecular epidemiology of lung cancer

Table of Contents: “…Contents: The influence of host factors on individual susceptibility to tobacco smoke -- The pleiotropic genes that control activation (Phase I) and detoxification (Phase II) of potential carcinogens -- Effects of the metabolism of environmental compounds on the lipophilic properties of a molecule and the introduction of electronegative moieties within the molecule on carcinogenic potential -- Other susceptibility factors related to defects in DNA repair, alterations in tumor suppressor genes and alterations in tumor invasiveness factors -- Polymorphisms in genes and the association of this with lung cancer development -- The role of inherited polymorphisms of genes involved in xenobiotic metabolism, DNA repair and tumor suppression/invasion (alone and in combination) in lung cancer risk, and modification of this risk by environmental factors such as smoking and diet.…”
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Monoclonal antibodies and the ErbB system in human cancer

Table of Contents: “…Contents: General properties of tumor cells -- Human breast cancer and the erbB2/neu oncogene and protein -- Targeted monoclonal antibodies -- Tyrosine kinase activity and dimerization -- Activation of the kinase of erbB2/neu -- Overexpression of erbB2/neu and EGFr -- The erbB family members -- Discussion of Herceptin -- Prevention of tumor growth in a neoadjuvant model -- Two antibody therapy & tumor growth inhibition.…”
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Exploring and predicting phenotype and function in cancer biology working in high dimensional data spaces /

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Targeting apoptosis pathways in cancer therapy

Table of Contents: “…Contents: Apoptosis pathways -- Pathways regulating the intrinsic and extrinsic pathways -- ovel therapeutic agents in cancer therapy that target the apoptosis pathways and the modulators of apoptosis.…”
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Targeting apoptosis pathways in cancer therapy

Table of Contents: “…Contents: Apoptosis in cancer -- Apoptosis signalling pathways -- Death receptor pathway -- Mitochondrial pathway -- Targeting the death receptor pathway -- Bcl-2 family proteins: structure and function -- Targeting Bcl-2 family proteins -- IAPs: structure and function -- Targeting IAPs.…”
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Diagnosis of early relapse in ovarian cancer using serum proteomic profiling

Table of Contents: “…Contents: Surface-enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry data -- Use of Biomarkers to identify diverse early disease detection -- Ovarian cancer relapse diagnosis -- SVM-MB/RFE: Support Vector Machine- Markov Blanket/Recursive Feature Elimination to identify biomarkers for predicting the early recurrence of ovarian cancer by analyzing SELDI-TOF mass spectrometry data.…”
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Checkpoint blockade in cancer immunotherapy

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Anti-IL-2 receptor antibodies as models for cancer therapy

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Viruses and cancer

Table of Contents: “…Contents: Oncogenic viruses of animals and humans have given us insights into cancer in general -- Specific genes involved in cancer such as oncogenes and tumor suppressor genes were first discovered through research on tumor viruses -- Only a subset of viruses cause cancer -- For cancers caused by viruses, the viruses are a necessary but insufficient cause of the disease -- Cancer is multifactorial and different risk factors act together -- Vaccines hold great promise to reduce the cancer burden -- The incidence is higher in immunodeficient people -- Transplant recipients and AIDS.…”
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Reprogramming oxidative phosphorylation in cancer

Table of Contents: “…Contents: Overview of oxidative phosphorylation -- ATP synthase and its regulation by IF1 -- Functions of ATP synthase/hydrolase in cancer -- Aerobic glycolysis and cellular proliferation status -- Metabolic reprogramming in proliferation -- mRNA binding proteins in translation silencing & cancer progression -- Overexpression of IF1 in cancer.…”
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A Darwinian eye view of cancer

Table of Contents: “…Contents: The prevalence of cancer: man vs. animals -- The proximal causes of cancer: mutations and genotoxic exposures -- Limitations of evolutionary adaptation by natural selection -- Vulnerability to cancer from an evolutionary perspective -- Lack of perfection in evolutionary 'engineering': faults/trade-offs -- Evolutionary adaptation 'has no eyes to the future': mismatches between genetics and lifestyle -- Natural selection will happen: evolution of robust cancer clones -- The only fitness test of 'natural selectability' in evolution is survival and reproductive success: cancer risk escalation in old age.…”
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Colorectal cancer and the rare variant hypothesis

Table of Contents: “…Contents: Cancer: a somatic evolutionary process -- Colorectal cancer: a good model to study -- Two clear cut familial forms: FAP and HNPCC -- Mutation selection balance for dominants and recessives: application to FAP -- APC gene found by positional cloning -- Loss of heterozygosity proved its role in sporadic cancers -- Selection for mutations in the APC "mutation cluster region" -- HNPCC mismatch repair genes found by candidate guess -- Mutated genes in colorectal cancer include p53 and wnt pathway, occur in adenoma to carcinoma sequence -- Arguments for and against need for genomic instability in cancers -- Epigenetic changes -- Mathematical model of normal and cancerous crypt -- Types of familial cancers: mostly rarer than FAP and HNPCC -- Approaches to studying multifactorial inherited susceptibility -- HLA and disease: the model -- Role of linkage disequilbrium -- Principles of SNP association analysis -- Rare missense variants in the APC gene confer susceptibility -- The "rare variant hypothesis" for multifactorial inherited susceptibility: exemplified by study of colorectal adenomas.…”
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The genetics of breast and ovarian cancer

Table of Contents: “…Contents: General cancer genetics -- Tumor suppressor and oncogenes -- Knudson's 'two hit' hypothesis -- Genetic predisposition to breast and ovarian cancer -- How much breast and ovarian cancer is inherited and the causes (genes responsible) -- Cancer risk in populations -- Factors that affect penetrance -- Mutation detection -- Risk reduction and prevention strategies.…”
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Vitamin D and prostate cancer

Table of Contents: “…Contents: Vitamin D actions: classical view and expanded view -- Vitamin D metabolic pathways -- Vitamin D and cancers -- Vitamin D-deficiency hypothesis -- Sunlight, vitamin D and prostate cancer risk -- Importance of local production of calcitriol -- Importance of 24-hydroxylase activity level -- Differential sensitivity to antiproliferative actions of calcitriol -- Inhibition of 24-hydroxylase activity by liarozole -- Anti-cancer mechanisms -- Calcitriol and inflammation -- COX-2 actions and prostate cancer -- Inflammatory mechanisms in carcinogenesis -- COX-2 and PG induction of cancer -- Three calcitriol actions to inhibit PG activity -- Potential synergy of calcitriol with NSAIDs -- Results of vitamin D therapy in in vivo trials of prostate cancer -- Calcitriol and naproxen -- Genetic mouse model of PIN-HG-PIN -- High dose intermittent calcitriol plus docetaxol.…”
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Steroid hormones and their receptors in breast cancer

Table of Contents: “…Contents: Development and types of breast cancers -- Molecular and cellular aspects of hormone action on breast cells -- Natural and synthetic estrogens -- Basis for endocrine therapies -- Alternative/emerging therapeutic approaches -- Strategies for breast cancer prevention.…”
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Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases

Table of Contents: “…-- Outstanding medical issues -- Regulatory status of HPV VLP vaccines -- Pap smear screening without vaccination would prevent more cervical cancer deaths than HPV16/18 vaccination without pap screening -- Limitations of current VLP vaccines.…”
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Targeting cancer designing drugs against Hsp90 /

Table of Contents: “…Contents: Heat shock protein 90 (Hsp90), a target in cancer -- Discovery of the first known Hsp90 inhibitor, geldanamycin -- Use of geldanamycin to understand the role of Hsp90 in malignant transformation -- Discovery of novel Hsp90 inhibitors -- Development and applications of Hsp90 inhibitors.…”
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